{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:22:41Z","timestamp":1790648561294,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Research Council Discovery Early Career Research Award"},{"DOI":"10.13039\/501100006630","name":"Lung Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC UK","doi-asserted-by":"publisher","award":["U105178805"],"award-info":[{"award-number":["U105178805"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100963\/Z\/13\/Z"],"award-info":[{"award-number":["100963\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008918","name":"Faculty of Health and Medicine, The University of Newcastle","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006630","name":"Lung Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["U105178805"],"award-info":[{"award-number":["U105178805"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100963\/Z\/13\/Z"],"award-info":[{"award-number":["100963\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008918","name":"Faculty of Health and Medicine, University of Newcastle Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1\u2212\/\u2212 and Rorafl\/flIl7rCre [ILC2-deficient] mice). Wild-type (WT) C57BL\/6 mice, Rag1\u2212\/\u2212, and Rorafl\/flIl7rCre mice were exposed to cigarette smoke (CS; 12 cigarettes twice a day, 5 days a week) for up to 12 weeks, and airway inflammation, airway remodelling (collagen deposition and alveolar enlargement), and lung function were assessed. WT, Rag1\u2212\/\u2212, and ILC2-deficient mice exposed to CS had similar levels of airway inflammation and impaired lung function. CS exposure increased small airway collagen deposition in WT mice. Rag1\u2212\/\u2212 normal air- and CS-exposed mice had significantly increased collagen deposition compared to similarly exposed WT mice, which was associated with increases in IL-33, IL-13, and ILC2 numbers. CS-exposed Rorafl\/flIl7rCre mice were protected from emphysema, but had increased IL-33\/IL-13 expression and collagen deposition compared to WT CS-exposed mice. T\/B lymphocytes and ILC2s play roles in airway collagen deposition\/fibrosis, but not inflammation, in experimental COPD.<\/jats:p>\n                  <jats:p>T\/B lymphocytes and ILC2s play roles in airway fibrosis but not inflammation in a mouse model of experimental COPD.<\/jats:p>","DOI":"10.1002\/jlb.3ab0518-178r","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T10:42:41Z","timestamp":1538044961000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Roles for T\/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease"],"prefix":"10.1093","volume":"105","author":[{"given":"Chantal","family":"Donovan","sequence":"first","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm R","family":"Starkey","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batika M J","family":"Rana","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Laboratory of Molecular Biology , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian L","family":"Barlow","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Laboratory of Molecular Biology , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Jones","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatt Jhong","family":"Haw","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Mono Nair","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis","family":"Budden","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy J M","family":"Cameron","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C","family":"Horvat","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Wark","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S","family":"Foster","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N J","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Laboratory of Molecular Biology , Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Priority Research Centres for Healthy Lungs and GrowUpWell, Hunter Medical Research Institute and The University of Newcastle , Newcastle, New South Wales, Australia"},{"name":"The Centenary Institute and the School of Life Sciences, University of Technology Sydney , Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"2023032406270712700_jlb10239-cit-0001","article-title":"POCKET GUIDE TO COPD DIAGNOSIS, MANAGEMENT, AND PREVENTION A Guide for Health Care Professionals 2017 REPORT","author":"Global Initiative for Chronic Obstructive Lung Disease","year":"2017"},{"key":"2023032406270712700_jlb10239-cit-0002","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0003","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"2023032406270712700_jlb10239-cit-0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/resp.12908","article-title":"Animal models of COPD: what do they tell us?","volume":"22","author":"Jones","year":"2017","journal-title":"Respirology"},{"key":"2023032406270712700_jlb10239-cit-0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1513\/pats.200701-002FM","article-title":"The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research","volume":"4","author":"Curtis","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"2023032406270712700_jlb10239-cit-0006","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/mi.2013.77","article-title":"DAMPs activating innate and adaptive immune responses in COPD","volume":"7","author":"Pouwels","year":"2014","journal-title":"Mucosal Immunol"},{"key":"2023032406270712700_jlb10239-cit-0007","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00154.2017","article-title":"Toll-like receptor 2 and 4 have opposing roles in the pathogenesis of cigarette smoke-induced chronic obstructive pulmonary disease","author":"Haw","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2023032406270712700_jlb10239-cit-0008","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ni.3421","article-title":"Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation","volume":"17","author":"Monticelli","year":"2016","journal-title":"Nat Immunol"},{"key":"2023032406270712700_jlb10239-cit-0009","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2131","article-title":"Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus","volume":"12","author":"Monticelli","year":"2011","journal-title":"Nat Immunol"},{"key":"2023032406270712700_jlb10239-cit-0010","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ni.3444","article-title":"IL-1beta, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs","volume":"17","author":"Bal","year":"2016","journal-title":"Nat Immunol"},{"key":"2023032406270712700_jlb10239-cit-0011","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ni.3443","article-title":"Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs","volume":"17","author":"Silver","year":"2016","journal-title":"Nat Immunol"},{"key":"2023032406270712700_jlb10239-cit-0012","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2015.02.011","article-title":"Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection","volume":"42","author":"Kearley","year":"2015","journal-title":"Immunity"},{"key":"2023032406270712700_jlb10239-cit-0013","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.4049\/jimmunol.0802622","article-title":"Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease","volume":"182","author":"Zhu","year":"2009","journal-title":"J Immunol"},{"key":"2023032406270712700_jlb10239-cit-0014","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1164\/ajrccm.157.3.9709027","article-title":"CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease","volume":"157","author":"Saetta","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0015","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1056\/NEJMra0804752","article-title":"Immunologic aspects of chronic obstructive pulmonary disease","volume":"360","author":"Cosio","year":"2009","journal-title":"N Engl J Med"},{"key":"2023032406270712700_jlb10239-cit-0016","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1183\/09031936.06.00007005","article-title":"Increased number of B-cells in bronchial biopsies in COPD","volume":"27","author":"Gosman","year":"2006","journal-title":"Eur Respir J"},{"key":"2023032406270712700_jlb10239-cit-0017","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.yexmp.2007.08.020","article-title":"CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure","volume":"83","author":"Borchers","year":"2007","journal-title":"Exp Mol Pathol"},{"key":"2023032406270712700_jlb10239-cit-0018","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.4049\/jimmunol.178.12.8090","article-title":"CD8+ T cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice","volume":"178","author":"Maeno","year":"2007","journal-title":"J Immunol"},{"key":"2023032406270712700_jlb10239-cit-0019","doi-asserted-by":"crossref","first-page":"L687","DOI":"10.1152\/ajplung.00304.2016","article-title":"B cells in chronic obstructive pulmonary disease: moving to center stage","volume":"311","author":"Polverino","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2023032406270712700_jlb10239-cit-0020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm1583","article-title":"Antielastin autoimmunity in tobacco smoking-induced emphysema","volume":"13","author":"Lee","year":"2007","journal-title":"Nat Med"},{"key":"2023032406270712700_jlb10239-cit-0021","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/rccm.201001-0029OC","article-title":"Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease","volume":"183","author":"Nunez","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0022","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1164\/rccm.200911-1700OC","article-title":"A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family","volume":"182","author":"Polverino","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0023","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1164\/rccm.201501-0103OC","article-title":"Role of B cell-activating factor in chronic obstructive pulmonary disease","volume":"192","author":"Seys","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0024","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1164\/rccm.200910-1485OC","article-title":"Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-\/- mice","volume":"181","author":"Motz","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0025","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jaci.2012.11.053","article-title":"A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis","volume":"131","author":"Beckett","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406270712700_jlb10239-cit-0026","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.86380","article-title":"Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases","volume":"1","author":"Liu","year":"2016","journal-title":"JCI Insight"},{"key":"2023032406270712700_jlb10239-cit-0027","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1164\/rccm.201501-0188OC","article-title":"Targeting PI3K-p110alpha suppresses influenza virus infection in chronic obstructive pulmonary disease","volume":"191","author":"Hsu","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0028","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1074\/jbc.M114.548594","article-title":"Importance of mast cell Prss31\/transmembrane tryptase\/tryptase-gamma in lung function and experimental chronic obstructive pulmonary disease and colitis","volume":"289","author":"Hansbro","year":"2014","journal-title":"J Biol Chem"},{"key":"2023032406270712700_jlb10239-cit-0029","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/mi.2015.111","article-title":"A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease","volume":"9","author":"Haw","year":"2016","journal-title":"Mucosal Immunol"},{"key":"2023032406270712700_jlb10239-cit-0030","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1111\/bph.13573","article-title":"The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model","volume":"173","author":"Jarnicki","year":"2016","journal-title":"Br J Pharmacol"},{"key":"2023032406270712700_jlb10239-cit-0031","doi-asserted-by":"crossref","first-page":"e90443","DOI":"10.1172\/jci.insight.90443","article-title":"MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD","volume":"2","author":"Hsu","year":"2017","journal-title":"JCI Insight"},{"key":"2023032406270712700_jlb10239-cit-0032","doi-asserted-by":"crossref","first-page":"e1004549","DOI":"10.1371\/journal.ppat.1004549","article-title":"Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung","volume":"11","author":"Tay","year":"2015","journal-title":"PLoS Pathog"},{"key":"2023032406270712700_jlb10239-cit-0033","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4049\/jimmunol.1700927","article-title":"Osteoblasts are rapidly ablated by virus-induced systemic inflammation following lymphocytic choriomeningitis virus or pneumonia virus of mice infection in mice","volume":"2","author":"Maltby","year":"2018","journal-title":"J Immunol"},{"key":"2023032406270712700_jlb10239-cit-0034","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"key":"2023032406270712700_jlb10239-cit-0035","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.4049\/jimmunol.1101299","article-title":"Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells","volume":"188","author":"Thorburn","year":"2012","journal-title":"J Immunol"},{"key":"2023032406270712700_jlb10239-cit-0036","doi-asserted-by":"crossref","first-page":"e39460","DOI":"10.1371\/journal.pone.0039460","article-title":"TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life","volume":"7","author":"Beckett","year":"2012","journal-title":"PLoS One"},{"key":"2023032406270712700_jlb10239-cit-0037","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/thoraxjnl-2014-206067","article-title":"Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma","volume":"70","author":"Essilfie","year":"2015","journal-title":"Thorax"},{"key":"2023032406270712700_jlb10239-cit-0038","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.200607-1005OC","article-title":"Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease","volume":"176","author":"Horvat","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406270712700_jlb10239-cit-0039","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jaci.2016.04.038","article-title":"MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2","volume":"139","author":"Kim","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406270712700_jlb10239-cit-0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/mi.2012.99","article-title":"Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease","volume":"6","author":"Starkey","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2023032406270712700_jlb10239-cit-0041","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/j.1365-2222.2011.03806.x","article-title":"Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity","volume":"41","author":"Barlow","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"2023032406270712700_jlb10239-cit-0042","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1128\/MCB.18.8.4670","article-title":"Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences","volume":"18","author":"Akamatsu","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2023032406270712700_jlb10239-cit-0043","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.jaci.2014.05.011","article-title":"IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice","volume":"134","author":"Li","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2023032406270712700_jlb10239-cit-0044","doi-asserted-by":"crossref","first-page":"337ra65","DOI":"10.1126\/scitranslmed.aaf1938","article-title":"Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis","volume":"8","author":"Vannella","year":"2016","journal-title":"Sci Transl Med"},{"key":"2023032406270712700_jlb10239-cit-0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1177\/039463200601900303","article-title":"Timp-1 is a key factor of fibrogenic response to bleomycin in mouse lung","volume":"19","author":"Manoury","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2023032406270712700_jlb10239-cit-0046","doi-asserted-by":"crossref","first-page":"e13242","DOI":"10.1371\/journal.pone.0013242","article-title":"Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10","volume":"5","author":"Garc\u00eda-Prieto","year":"2010","journal-title":"PLoS One"},{"key":"2023032406270712700_jlb10239-cit-0047","doi-asserted-by":"crossref","first-page":"e0181945","DOI":"10.1371\/journal.pone.0181945","article-title":"TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury","volume":"12","author":"Schwanekamp","year":"2017","journal-title":"PLoS One"},{"key":"2023032406270712700_jlb10239-cit-0048","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature14115","article-title":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity","volume":"519","author":"Brestoff","year":"2015","journal-title":"Nature"},{"key":"2023032406270712700_jlb10239-cit-0049","doi-asserted-by":"crossref","first-page":"e1002365","DOI":"10.1371\/journal.pmed.1002365","article-title":"IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: a reverse translation study from a human cohort to a mouse trauma model","volume":"14","author":"Xu","year":"2017","journal-title":"PLoS Med"},{"key":"2023032406270712700_jlb10239-cit-0050","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1084\/jem.20130071","article-title":"IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation","volume":"210","author":"Turner","year":"2013","journal-title":"J Exp Med"},{"key":"2023032406270712700_jlb10239-cit-0051","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/all.12593","article-title":"IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk","volume":"70","author":"Kaur","year":"2015","journal-title":"Allergy"},{"key":"2023032406270712700_jlb10239-cit-0052","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1378\/chest.103.5.1470","article-title":"Effects of obesity on respiratory resistance","volume":"103","author":"Zerah","year":"1993","journal-title":"Chest"},{"key":"2023032406270712700_jlb10239-cit-0053","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/resp.12841","article-title":"Airway remodelling in COPD: It's not asthma!","volume":"21","author":"Jones","year":"2016","journal-title":"Respirology"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.3AB0518-178R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3AB0518-178R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3AB0518-178R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/143\/49557428\/jlb10239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/1\/143\/49557428\/jlb10239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T02:38:13Z","timestamp":1679625493000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/105\/1\/143\/6935429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,9,27]]},"published-print":{"date-parts":[[2018,12,27]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3ab0518-178r","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,9,27]]}}}