{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:16:59Z","timestamp":1790727419178,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":472,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The NF-\u03baB transcription factor c-Rel plays a crucial role in promoting and regulating immune responses and inflammation. However, the function of c-Rel in modulating the mucosal immune system is poorly understood. T follicular helper (Tfh) cells and IgA production in gut-associated lymphoid tissues (GALT) such as Peyer's patches (PPs) are important for maintaining the intestinal homeostasis. Here, c-Rel was identified as an essential factor regulating intestinal IgA generation and function of Tfh cells. Genetic deletion of c-Rel resulted in the aberrant formation of germinal centers (GCs) in PPs, significantly reduced IgA generation and defective Tfh cell differentiation. Supporting these findings, the Ag-specific IgA response to Citrobacter rodentium was strongly impaired in c-Rel-deficient mice. Interestingly, an excessive expansion of segmented filamentous bacteria (SFB) was observed in the small intestine of animals lacking c-Rel. Yet, the production of IL-17A, IgA, and IL-21, which are induced by SFB, was impaired due to the lack of transcriptional control by c-Rel. Collectively, the transcriptional activity of c-Rel regulates Tfh cell function and IgA production in the gut, thus preserving the intestinal homeostasis.<\/jats:p>","DOI":"10.1002\/jlb.3ab0621-350r","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T06:02:59Z","timestamp":1633845779000},"page":"1001-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcription factor c-Rel mediates communication between commensal bacteria and mucosal lymphocytes"],"prefix":"10.1093","volume":"111","author":[{"given":"Maik","family":"Luu","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"},{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg , W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Binder","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"},{"name":"Institute for Pathology, Universit\u00e4tsklinikum Giessen , Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Kespohl","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"},{"name":"Institute of Biochemistry, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Bazant","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"},{"name":"Institute for Medical Microbiology, Justus Liebig University , Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Romero","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Institute for Anatomy and Cell Biology, Philipps-University , Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, Philipps-University , Marburg, 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