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However, its role in T helper cell differentiation and function remains poorly understood. In this study, it is shown that the restraint of iron availability through blocking CD71-mediated iron endocytosis impaired the differentiation and pathogenicity of TH17 cells. Administrations of anti-CD71 mAb could relieve the development of experimental autoimmune encephalomyelitis (EAE). Mechanistically, the iron deficiency due to the blocking of CD71 enhanced IL-2 expression, which further restrained the differentiation of TH17 cells. Meanwhile, CD71 blockade impaired histone modifications of Il17 gene and reduced the recruitment of ROR\u03b3t to Il17a locus. In sum, the findings reveal that iron plays a pivotal role in regulating TH17 cell differentiation and function in autoimmune diseases.<\/jats:p>","DOI":"10.1002\/jlb.3ma0821-015r","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T12:38:33Z","timestamp":1633696713000},"page":"1057-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Iron deprivation restrains the differentiation and pathogenicity of T helper 17 cell"],"prefix":"10.1093","volume":"110","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, 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