{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:05:14Z","timestamp":1791824714294,"version":"4.3.4"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Melanoma is a very lethal tumor type that easily spreads and colonizes regional and distant tissues. Crucial phenotypic changes that favor melanoma metastasis are interposed by the tumor microenvironment (TME), representing a complex network in which malignant cells communicate not only with each other but also with stromal and immune cells. This cell-cell communication can be mediated by extracellular vesicles (EVs), which are lipid bilayer-delimited particles capable of carrying a wide variety of bioactive compounds. Both melanoma-derived or TME-derived EVs deliver important pro- and antitumor signals implicated in various stages of tumor progression, such as proliferation, metastasis, and treatment response. In this review, we highlight the recent advances in EV-mediated crosstalk between melanoma and immune cells and other important cells of the TME, and address different aspects of this bidirectional interaction as well as how this may hinder or trigger the development and progression of melanoma. We also discuss the potential of using EVs as biomarkers and therapeutic strategies for melanoma.<\/jats:p>","DOI":"10.1002\/jlb.3mr0320-644r","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T22:25:50Z","timestamp":1590445550000},"page":"1101-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Extracellular vesicle-mediated crosstalk between melanoma and the immune system: Impact on tumor progression and therapy response"],"prefix":"10.1093","volume":"108","author":[{"given":"Marco Ant\u00f4nio Marques","family":"Pretti","sequence":"first","affiliation":[{"name":"Bioinformatics and Computational Biology Laboratory, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"},{"name":"Program of Immunology and Tumor Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Santos","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Program of Immunology and Tumor Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"},{"name":"Tissue Microenvironment Laboratory, Department of General Pathology, Federal University of Minas Gerais , Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Gon\u00e7alves Vieira","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Laboratory, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-9917","authenticated-orcid":true,"given":"Mariana","family":"Boroni","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Laboratory, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-0969","authenticated-orcid":true,"given":"Patr\u00edcia A","family":"Possik","sequence":"additional","affiliation":[{"name":"Program of Immunology and Tumor Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"2023032108071748200_jlb10667-cit-0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc.2016.37","article-title":"From melanocytes to melanomas","volume":"16","author":"Shain","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"2023032108071748200_jlb10667-cit-0002","doi-asserted-by":"crossref","first-page":"14343","DOI":"10.1038\/ncomms14343","article-title":"Microenvironment-derived factors driving metastatic plasticity in melanoma","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"2023032108071748200_jlb10667-cit-0003","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-018-0812-9","article-title":"Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in 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