{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:03:37Z","timestamp":1761491017944,"version":"3.37.3"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2014-04023"],"award-info":[{"award-number":["RGPIN-2014-04023"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","award":["MOP-340405","PJT-4072276"],"award-info":[{"award-number":["MOP-340405","PJT-4072276"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102014\u201004023"],"award-info":[{"award-number":["RGPIN\u20102014\u201004023"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intestinal amebiasis is the disease caused by the extracellular protozoan parasite Entamoeba histolytica (Eh) that induces a dynamic and heterogeneous interaction profile with the host immune system during disease pathogenesis. In 90% of asymptomatic infection, Eh resides with indigenous microbiota in the outer mucus layer of the colon without prompting an immune response. However, for reasons that remain unclear, in a minority of the Eh-infected individuals, this fine tolerated relationship is switched to a pathogenic phenotype and advanced to an increasingly complex host-parasite interaction. Eh disease susceptibility depends on parasite virulence factors and their interactions with indigenous bacteria, disruption of the mucus bilayers, and adherence to the epithelium provoking host immune cells to evoke a robust pro-inflammatory response mediated by inflammatory caspases and inflammasome activation. To understand Eh pathogenicity and innate host immune responses, this review highlights recent advances in our understanding of how Eh induces outside-in signaling via M\u03d5s to activate inflammatory caspases and inflammasome to regulate pro-inflammatory responses.<\/jats:p>","DOI":"10.1002\/jlb.3mr0420-465r","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T21:31:54Z","timestamp":1591306314000},"page":"801-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of inflammasomes in innate host defense against <i>Entamoeba histolytica<\/i>"],"prefix":"10.1093","volume":"108","author":[{"given":"Sharmin","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre , Calgary, Alberta , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre , Calgary, Alberta , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attinder","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre , Calgary, Alberta , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-557X","authenticated-orcid":true,"given":"Kris","family":"Chadee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary Health Sciences Centre , Calgary, Alberta , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"2023032108163478700_jlb10692-cit-0001","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.exppara.2010.03.005","article-title":"The immunopathogenesis of Entamoeba histolytica","volume":"126","author":"Mortimer","year":"2010","journal-title":"Exp Parasitol"},{"key":"2023032108163478700_jlb10692-cit-0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pt.2011.02.006","article-title":"Tissue destruction and invasion by Entamoeba histolytica","volume":"27","author":"Ralston","year":"2011","journal-title":"Trends Parasitol"},{"key":"2023032108163478700_jlb10692-cit-0003","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.trstmh.2005.12.012","article-title":"Entamoeba histolytica-associated diarrheal illness is negatively associated with the growth of preschool children: evidence from a prospective 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