{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:43:19Z","timestamp":1792644199488,"version":"4.5.0"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The underlying mechanisms and treatment of painful temporomandibular disorders (TMDs) are important but understudied topics in craniofacial research. As a group of musculoskeletal diseases, the onset of painful TMD is proved to be a result of disturbance of multiple systems. Recently, emerging evidence has revealed the involvement of neuroimmune interactions in painful TMD. Inflammatory factors play an important role in peripheral sensitization of temporomandibular joint (TMJ), and neurogenic inflammation in turn enhances TMJs dysfunction in TMD. Furthermore, centralized neuroimmune communications contribute to neuron excitability amplification, leading to pain sensitization, and is also responsible for chronic TMD pain and other CNS symptoms. Therapeutics targeting neuroimmune interactions may shed light on new approaches for treating TMD. In this review, we will discuss the role of neuroimmune interactions in the onset of painful TMD from the peripheral and centralized perspectives, and how understanding this mechanism could provide new treatment options. Insights into the neuroimmune interactions within TMJs and painful TMD would broaden the knowledge of mechanisms and treatments of this multifactorial disease.<\/jats:p>","DOI":"10.1002\/jlb.3mr0621-731rr","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T03:08:39Z","timestamp":1627528119000},"page":"553-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neuroimmune interactions in painful TMD: Mechanisms and treatment implications"],"prefix":"10.1093","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-1959","authenticated-orcid":false,"given":"Yating","family":"Yi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University , No. 14 Section 3, Renmin South Road, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-6703","authenticated-orcid":false,"given":"Xueman","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University , No. 14 Section 3, Renmin South Road, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-0970","authenticated-orcid":false,"given":"Xin","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University , No. 14 Section 3, Renmin South Road, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-6295","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University , No. 14 Section 3, Renmin South Road, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2023032108502933100_","volume-title":"Temporomandibular Disorders: Priorities for Research and Care. The National Academies Collection: Reports funded by National Institutes of Health","author":"Yost","year":"2020"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/AJP.0b013e31820e12f5","article-title":"Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study","volume":"27","author":"Goncalves","year":"2011","journal-title":"Clin J Pain"},{"key":"2023032108502933100_","volume-title":"The TMJ patient-led RoundTable: a history and summary of work","author":"Kusiak","year":"2018"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1248\/bpb.b18-00442","article-title":"Inflammation and temporomandibular joint derangement","volume":"42","author":"Ibi","year":"2019","journal-title":"Biol Pharm Bull"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1177\/0022034516657070","article-title":"Pain mechanisms and centralized pain in temporomandibular disorders","volume":"95","author":"Harper","year":"2016","journal-title":"J Dent Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.immuni.2020.02.017","article-title":"Neuro-immune interactions in the tissues","volume":"52","author":"Chu","year":"2020","journal-title":"Immunity"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.00014.2017","article-title":"Impact of the autonomic nervous system on the skeleton","volume":"98","author":"Elefteriou","year":"2018","journal-title":"Physiol Rev"},{"issue":"10","key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.celrep.2016.08.002","article-title":"NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone","volume":"16","author":"Tomlinson","year":"2016","journal-title":"Cell Reports"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuroscience.2006.03.049","article-title":"Inflammation increases the excitability of masseter muscle afferents","volume":"141","author":"Harriott","year":"2006","journal-title":"Neuroscience"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1744806917697011","DOI":"10.1177\/1744806917697011","article-title":"Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain","volume":"13","author":"Nencini","year":"2017","journal-title":"Mol Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/joim.12591","article-title":"Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence","volume":"282","author":"Lai","year":"2017","journal-title":"J Intern Med"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00001665-200303000-00019","article-title":"Clinical implications of the innervation of the temporomandibular joint","volume":"14","author":"Davidson","year":"2003","journal-title":"J Craniofac Surg"},{"key":"2023032108502933100_","first-page":"94","volume-title":"Specialty Imaging: Temporomandibular Joint","author":"TMJ Innervation","year":"2016"},{"key":"2023032108502933100_","first-page":"67","volume-title":"Anatomy and Pathophysiology of the Temporomandibular Joint, in Functional Occlusion in Restorative Dentistry and Prosthodontics","author":"Palla","year":"2016"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1679\/aohc.66.289","article-title":"Synovial membrane in the temporomandibular joint\u2013its morphology, function and development","volume":"66","author":"Nozawa-Inoue","year":"2003","journal-title":"Arch Histol Cytol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0196-9781(02)00015-3","article-title":"mu-Opioid receptor mRNA expression and immunohistochemical localization in the rat temporomandibular joint","volume":"23","author":"Hayashi","year":"2002","journal-title":"Peptides"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"0210031","DOI":"10.1115\/1.4035647","article-title":"The interface of mechanics and nociception in joint pathophysiology: insights from the facet and temporomandibular joints","volume":"139","author":"Sperry","year":"2017","journal-title":"J Biomech Eng"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and therapeutic relevance of neuro-immune communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/cphy.c130051","article-title":"Autonomic nervous system and immune system interactions","volume":"4","author":"Kenney","year":"2014","journal-title":"Compr Physiol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2009.09.009","article-title":"Immune and nervous systems: more than just a superficial similarity?","volume":"31","author":"Kioussis","year":"2009","journal-title":"Immunity"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1073\/pnas.0702553104","article-title":"Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits","volume":"104","author":"Tang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1810","article-title":"Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens","volume":"6","author":"Sternberg","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-immunol-042617-053158","article-title":"Molecular and functional neuroscience in immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.it.2007.07.005","article-title":"The emergence of neurotransmitters as immune modulators","volume":"28","author":"Franco","year":"2007","journal-title":"Trends Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3389\/fimmu.2020.01869","article-title":"Critical neurotransmitters in the neuroimmune network","volume":"11","author":"Hodo","year":"2020","journal-title":"Front Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-013-9752-4","article-title":"Control of bone remodeling by the peripheral sympathetic nervous system","volume":"94","author":"Elefteriou","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"30085","DOI":"10.1038\/srep30085","article-title":"Activation of alpha2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint","volume":"6","author":"Jiao","year":"2016","journal-title":"Sci Rep"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"12593","DOI":"10.1038\/srep12593","article-title":"beta2-Adrenergic signal transduction plays a detrimental role in subchondral bone loss of temporomandibular joint in osteoarthritis","volume":"5","author":"Jiao","year":"2015","journal-title":"Sci Rep"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"9327487","DOI":"10.1155\/2018\/9327487","article-title":"Profiling of stem\/progenitor cell regulatory genes of the synovial joint by genome-wide RNA-Seq analysis","volume":"2018","author":"Zhou","year":"2018","journal-title":"Biomed Res Int"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/154405910808700406","article-title":"Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment","volume":"87","author":"Tanaka","year":"2008","journal-title":"J Dent Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/2176-9451.20.1.127-133.sar","article-title":"TMD and chronic pain: a current view","volume":"20","author":"Furquim","year":"2015","journal-title":"Dental Press J Orthod"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4103\/njcp.njcp_117_18","article-title":"Rheumatoid arthritis in temporo-mandibular joint: a review","volume":"21","author":"Savtekin","year":"2018","journal-title":"Nigerian J Clin Pract"},{"key":"2023032108502933100_","first-page":"115","article-title":"How to live with rheumatoid arthritis","volume":"3","author":"Milind","year":"2012","journal-title":"Int Res J Pharm"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0976-237X.149308","article-title":"Rheumatoid arthritis affecting temporomandibular joint","volume":"6","author":"Sodhi","year":"2015","journal-title":"Contemp Clin Dent"},{"key":"2023032108502933100_","first-page":"11","article-title":"The role and treatment implications of peripheral and central processing of pain, pruritus, and nausea in heightened somatic awareness: a review","volume":"14","author":"Spiegel","year":"2017","journal-title":"Innov Clin Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-385198-7.00007-2","article-title":"Peripheral and central mechanisms of orofacial inflammatory pain","volume":"97","author":"Sessle","year":"2011","journal-title":"Int Rev Neurobiol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2842.2010.02074.x","article-title":"Pathophysiology of TMD pain\u2013basic mechanisms and their implications for pharmacotherapy","volume":"37","author":"Cairns","year":"2010","journal-title":"J Oral Rehabil"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/08869634.2017.1342890","article-title":"Expression of interleukin-1 and temporomandibular disorder: contemporary review of the literature","volume":"36","author":"Sorenson","year":"2018","journal-title":"Cranio"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0278-2391(98)90867-9","article-title":"The influence of neuropeptides, serotonin, and interleukin 1beta on temporomandibular joint pain and inflammation","volume":"56","author":"Kopp","year":"1998","journal-title":"J Oral Maxillofac Surg"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1259\/dmfr\/77288976","article-title":"Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study","volume":"35","author":"Matsumoto","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/0022034514560588","article-title":"Effects of enzymatic degradation after loading in temporomandibular joint","volume":"94","author":"Asakawa-Tanne","year":"2015","journal-title":"J Dent Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/08869634.2016.1207911","article-title":"Immunohistochemical analysis of IL-1 beta in the discs of patients with temporomandibular joint dysfunction","volume":"35","author":"Almeida","year":"2017","journal-title":"Cranio"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02274836","article-title":"Interleukin 1 beta in synovial fluid is related to local disease activity in rheumatoid arthritis","volume":"10","author":"Rooney","year":"1990","journal-title":"Rheumatol Int"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0278-2391(97)90438-9","article-title":"Interleukin 1 beta and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint","volume":"55","author":"Kubota","year":"1997","journal-title":"J Oral Maxillofac Surg"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s10194-017-0737-y","article-title":"Increased levels of intramuscular cytokines in patients with jaw muscle pain","volume":"18","author":"Louca Jounger","year":"2017","journal-title":"J Headache Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0306-4522(95)00106-S","article-title":"Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P","volume":"68","author":"Jeanjean","year":"1995","journal-title":"Neuroscience"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cyto.2016.08.014","article-title":"Molecular mechanisms of action of anti-TNF-\u03b1 agents \u2013 Comparison among therapeutic TNF-\u03b1 antagonists","volume":"101","author":"Mitoma","year":"2018","journal-title":"Cytokine"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/jop.12040","article-title":"Effects of interleukin-1\u03b2 and tumor necrosis factor-\u03b1 on macrophage inflammatory protein-3\u03b1 production in synovial fibroblast-like cells from human temporomandibular joints","volume":"42","author":"Akutsu","year":"2013","journal-title":"J Oral Pathol Med"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jcms.2014.10.017","article-title":"Tumor necrosis factor-alpha levels in the synovial fluid of patients with temporomandibular joint internal derangement","volume":"43","author":"G\u00fcven","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.archoralbio.2016.10.034","article-title":"Tumor necrosis factor-Alpha stimulates cytokine expression and transient sensitization of trigeminal nociceptive neurons","volume":"75","author":"Durham","year":"2017","journal-title":"Arch Oral Biol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/art.30150","article-title":"A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor \u03b1-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis","volume":"63","author":"Fernandes","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron-immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/jn.00652.2014","article-title":"The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-\u03b1-mediated increase in nociceptors excitability","volume":"113","author":"Gudes","year":"2015","journal-title":"J Neurophysiol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s11136-020-02581-8","article-title":"Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery","volume":"29","author":"Sebastiani","year":"2020","journal-title":"Q Life Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/0022034516678599","article-title":"Estrogen-induced monocytic response correlates with TMD pain: a case control study","volume":"96","author":"Ribeiro-Dasilva","year":"2017","journal-title":"J Dent Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s10194-017-0737-y","article-title":"Increased levels of intramuscular cytokines in patients with jaw muscle pain","volume":"18","author":"Louca Jounger","year":"2017","journal-title":"J Headache Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.1523\/JNEUROSCI.5161-13.2014","article-title":"Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression","volume":"34","author":"Malsch","year":"2014","journal-title":"J Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1476-5381.1992.tb14503.x","article-title":"The pivotal role of tumour necrosis factor ?? in the development of inflammatory hyperalgesia","volume":"107","author":"Cunha","year":"1992","journal-title":"Br J Pharmacol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/jez.1401160206","article-title":"Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo","volume":"116","author":"LEVI-MONTALCINI","year":"1951","journal-title":"J Exp Zool"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2014.03.054","article-title":"NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors","volume":"269","author":"Wong","year":"2014","journal-title":"Neuroscience"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1002\/art.30564","article-title":"Nerve growth factor: a key local regulator in the pathogenesis of inflammatory arthritis","volume":"63","author":"Raychaudhuri","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.semarthrit.2009.03.002","article-title":"Nerve growth factor in rheumatic diseases","volume":"40","author":"Seidel","year":"2010","journal-title":"Semin Arthritis Rheum"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11914-016-0326-z","article-title":"Emerging targets for the management of osteoarthritis pain","volume":"14","author":"Malfait","year":"2016","journal-title":"Curr Osteopor Rep"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.bjp.0701148","article-title":"Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor \u03b1","volume":"121","author":"Woolf","year":"1997","journal-title":"Br J Pharmacol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0006-8993(92)90364-F","article-title":"Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines","volume":"569","author":"Yoshida","year":"1992","journal-title":"Brain Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jpain.2012.03.005","article-title":"Hippocampal nerve growth factor potentiated by 17\u03b2-estradiol and involved in allodynia of inflamed TMJ in rat","volume":"13","author":"Wu","year":"2012","journal-title":"J Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s10194-020-01160-z","article-title":"Altered levels of salivary and plasma pain related markers in temporomandibular disorders","volume":"21","author":"Jasim","year":"2020","journal-title":"J Headache Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2340\/16501977-2593","article-title":"Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise","volume":"51","author":"Anna","year":"2019","journal-title":"J Rehabil Med"},{"issue":"7843","key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41586-020-03057-y","article-title":"Nociceptive nerves regulate haematopoietic stem cell mobilization","volume":"589","author":"Gao","year":"2021","journal-title":"Nature"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrn2333","article-title":"A common neurobiology for pain and pleasure","volume":"9","author":"Leknes","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s10194-016-0656-3","article-title":"Dopamine in plasma - a biomarker for myofascial TMD pain","volume":"17","author":"Dawson","year":"2016","journal-title":"J Head Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"159","DOI":"10.11607\/ofph.1210","article-title":"Effect of experimental tooth clenching on the release of \u03b2-endorphin","volume":"28","author":"Dawson","year":"2014","journal-title":"J Oral Fac Pain Head"},{"key":"2023032108502933100_","first-page":"56","article-title":"Pain, allodynia, and serum serotonin level in orofacial pain of muscular origin","volume":"13","author":"Ernberg","year":"1999","journal-title":"J Orofac Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/AJP.0000000000000154","article-title":"Effects of experimental tooth clenching on pain and intramuscular release of 5-HT and glutamate in patients with myofascial TMD","volume":"31","author":"Dawson","year":"2015","journal-title":"Clin J Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbi.2017.04.003","article-title":"Modulation of experimental arthritis by vagal sensory and central brain stimulation","volume":"64","author":"Bassi","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"10743","DOI":"10.7150\/thno.46719","article-title":"Mast cells as a unique hematopoietic lineage and cell system: from Paul Ehrlich's visions to precision medicine concepts","volume":"10","author":"Valent","year":"2020","journal-title":"Theranostics"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/joor.12265","article-title":"Histamine and substance P in synovial fluid of patients with temporomandibular disorders","volume":"42","author":"Li","year":"2015","journal-title":"J Oral Rehabil"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/1440-1681.12167","article-title":"Roles played by histamine in strenuous or prolonged masseter muscle activity in mice","volume":"40","author":"Yoneda","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.expneurol.2015.05.005","article-title":"A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: role of CGRP in orofacial pain","volume":"271","author":"Romero-Reyes","year":"2015","journal-title":"Exp Neurol"},{"key":"2023032108502933100_","first-page":"215","article-title":"Neuropeptides in the arthritic TMJ and symptoms and signs from the stomatognathic system with special consideration to rheumatoid arthritis","volume":"9","author":"Appelgren","year":"1995","journal-title":"J Orofac Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/00016359309040579","article-title":"Relation between intra-articular temperature of the arthritic temporomandibular joint and presence of calcitonin gene-related peptide in the joint fluid. A clinical study","volume":"51","author":"Appelgren","year":"1993","journal-title":"Acta Odontol Scand"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1177\/0022034510375284","article-title":"PAR(2) and temporomandibular joint inflammation in the rat","volume":"89","author":"Denadai-Souza","year":"2010","journal-title":"J Dent Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.4477","article-title":"Neural regulation of immunity: molecular mechanisms and clinical translation","volume":"20","author":"Pavlov","year":"2017","journal-title":"Nat Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000086200","article-title":"Why look in the brain for answers to temporomandibular disorder pain?","volume":"180","author":"Sarlani","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s10194-020-01131-4","article-title":"The neuro-pathophysiology of temporomandibular disorders-related pain: a systematic review of structural and functional MRI studies","volume":"21","author":"Yin","year":"2020","journal-title":"J Headache Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jocn.2009.05.006","article-title":"The role of microglia in central nervous system immunity and glioma immunology","volume":"17","author":"Yang","year":"2010","journal-title":"J Clin Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2009.11.3\/mbelanger","article-title":"The role of astroglia in neuroprotection","volume":"11","author":"Belanger","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/1073858410386801","article-title":"Role of glia in orofacial pain","volume":"17","author":"Chiang","year":"2011","journal-title":"Neuroscientist"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/BOR.0000000000000354","article-title":"Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?","volume":"29","author":"Miller","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1744-8069-7-94","article-title":"Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization","volume":"7","author":"Cady","year":"2011","journal-title":"Mol Pain"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1111\/bph.15263","article-title":"Preclinical studies investigating the neural mechanisms involved in the co-morbidity of migraine and temporomandibular disorders: the role of CGRP","volume":"177","author":"Akerman","year":"2020","journal-title":"Br J Pharmacol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2018.09.005","article-title":"The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints","volume":"391","author":"Bonfante","year":"2018","journal-title":"Neuroscience"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12974-016-0565-z","article-title":"Differential expression of P2\u00d77 receptor and IL-1beta in nociceptive and neuropathic pain","volume":"13","author":"Luchting","year":"2016","journal-title":"J Neuroinflamm"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12974-016-0556-0","article-title":"Neuron-immune mechanisms contribute to pain in early stages of arthritis","volume":"13","author":"Nieto","year":"2016","journal-title":"J Neuroinflammation"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.176.7.3877","article-title":"The P2\u00d77 receptor: a key player in IL-1 processing and release","volume":"176","author":"Ferrari","year":"2006","journal-title":"J Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1001\/archinte.160.2.221","article-title":"Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder","volume":"160","author":"Aaron","year":"2000","journal-title":"Arch Intern Med"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"27","DOI":"10.11607\/ofph.1367","article-title":"Inflammatory cytokines and sleep disturbance in patients with temporomandibular disorders","volume":"30","author":"Park","year":"2016","journal-title":"J Oral Facial Pain Headache"},{"key":"2023032108502933100_","first-page":"93","article-title":"The reciprocal link between sleep and immune responses","volume":"152","author":"Del Gallo","year":"2014","journal-title":"Arch Ital Biol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2013.11.009","article-title":"Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint","volume":"125","author":"do Nascimento","year":"2014","journal-title":"Physiol Behav"},{"key":"2023032108502933100_","volume-title":"Temporomandibular Disorders: Priorities for Research and Care","author":"National Academies of Sciences E, Medicine"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain\u2013a review","volume":"7","author":"Leung","year":"2010","journal-title":"J Neuroinflamm"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00296-014-3016-0","article-title":"Soluble TNF receptors are produced at sites of inflammation and are inversely associated with self-reported symptoms (WOMAC) in knee osteoarthritis","volume":"34","author":"Sim?O","year":"2014","journal-title":"Rheumatol Int"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41419-020-2447-7","article-title":"CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-alpha in TMJ osteoarthritis","volume":"11","author":"Zhu","year":"2020","journal-title":"Cell Death Dis"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/ALN.0b013e31821b1ac5","article-title":"Antagonism of nerve growth factor-TrkA signaling and the relief of pain","volume":"115","author":"Mantyh","year":"2011","journal-title":"Anesthesiology"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/art.24096","article-title":"Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study","volume":"61","author":"Chevalier","year":"2009","journal-title":"Arthritis Rheum"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"9013283","DOI":"10.1155\/2020\/9013283","article-title":"Is lutikizumab, an anti-interleukin-1alpha\/beta dual variable domain immunoglobulin, efficacious for osteoarthritis? Results from a bayesian network meta-analysis","volume":"2020","author":"Cao","year":"2020","journal-title":"Biomed Res Int"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.4317\/medoral.18373","article-title":"Use of autologous conditioned serum (Orthokine) for the treatment of the degenerative osteoarthritis of the temporomandibular joint. Review of the literature","author":"Alvarez-Camino","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2023032108502933100_","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","journal-title":"Annu Rev Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/1529-0131(199904)42:4<710::AID-ANR14>3.0.CO;2-4","article-title":"Inhibition of tumor necrosis factor \u03b1\u2013induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways","volume":"42","author":"Marcial","year":"1999","journal-title":"Arthritis Rheum"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1212\/WNL.44.8.1523","article-title":"Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis","volume":"44","author":"Rieckmann","year":"1994","journal-title":"Neurology"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.orthres.2003.12.007","article-title":"Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10","volume":"22","author":"Zhang","year":"2004","journal-title":"J Orthop Res"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1440-1746.2012.07187.x","article-title":"Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells","volume":"27","author":"Sakai","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"109705","DOI":"10.1016\/j.biopha.2019.109705","article-title":"The role of IL-37 in skin and connective tissue diseases","volume":"122","author":"Pan","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.4049\/jimmunol.1801515","article-title":"IL-37 attenuates lung fibrosis by inducing autophagy and regulating TGF-beta1 production in mice","volume":"203","author":"Kim","year":"2019","journal-title":"J Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.1401810","article-title":"IL-37 alleviates rheumatoid arthritis by suppressing IL-17 and IL-17-triggering cytokine production and limiting Th17 cell proliferation","volume":"194","author":"Ye","year":"2015","journal-title":"J Immunol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1093\/rheumatology\/keaa192","article-title":"IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway","volume":"59","author":"Luo","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.joca.2018.08.016","article-title":"IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3","volume":"27","author":"van Geffen","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"e12692","DOI":"10.1111\/cpr.12692","article-title":"IL-37b alleviates inflammation in the temporomandibular joint cartilage via IL-1R8 pathway","volume":"52","author":"Luo","year":"2019","journal-title":"Cell Prolif"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study","volume":"284","author":"Silverstein","year":"2000","journal-title":"JAMA"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/annrheumdis-2018-214489","article-title":"Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis","volume":"78","author":"von Loga","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41584-020-00528-4","article-title":"The evolution of nerve growth factor inhibition in clinical medicine","volume":"17","author":"Wise","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/art.39492","article-title":"When is osteonecrosis not osteonecrosis?: Adjudication of reported serious adverse joint events in the tanezumab clinical development program","volume":"68","author":"Hochberg","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nmo.12792","article-title":"Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study","volume":"28","author":"Bonaz","year":"2016","journal-title":"Neurogastroenterol Motil"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/scientificamerican0315-28","article-title":"Shock Medicine","volume":"312","author":"Tracey","year":"2015","journal-title":"Sci Am"},{"key":"2023032108502933100_","first-page":"1","article-title":"Management of temporomandibular disorders with transcutaneous electrical nerve stimulation: a systematic review","author":"Fertout","year":"2019","journal-title":"CRANIO\u00ae"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.3390\/jcm9103330","article-title":"Immediate effect of masticatory muscle activity with transcutaneous electrical nerve stimulation in muscle pain of temporomandibular disorders patients","volume":"9","author":"Abe","year":"2020","journal-title":"J Clin Med"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"984","DOI":"10.5005\/jp-journals-10024-1792","article-title":"The role of transcutaneous electrical nerve stimulation in the management of temporomandibular joint disorder","volume":"16","author":"Awan","year":"2015","journal-title":"J Contemp Dent Pract"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1590\/1678-77572016-0173","article-title":"Short-term transcutaneous electrical nerve stimulation reduces pain and improves the masticatory muscle activity in temporomandibular disorder patients: a randomized controlled trial","volume":"25","author":"Ferreira","year":"2017","journal-title":"J Appl Oral Sci"},{"key":"2023032108502933100_","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/ptj\/86.5.710","article-title":"A systematic review of the effectiveness of physical therapy interventions for temporomandibular disorders","volume":"86","author":"McNeely","year":"2006","journal-title":"Phys Ther"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3MR0621-731RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3MR0621-731RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/110\/3\/553\/49464882\/jlb10993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/110\/3\/553\/49464882\/jlb10993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T11:34:15Z","timestamp":1699270455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/110\/3\/553\/6884671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":133,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,29]]},"published-print":{"date-parts":[[2021,8,26]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3mr0621-731rr","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9]]},"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}