{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:42:50Z","timestamp":1790754170136,"version":"4.1.0"},"reference-count":265,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although IL-34 and CSF-1 share actions as key mediators of monocytes\/macrophages survival and differentiation, they also display differences that should be identified to better define their respective roles in health and diseases. IL-34 displays low sequence homology with CSF-1 but has a similar general structure and they both bind to a common receptor CSF-1R, although binding and subsequent intracellular signaling shows differences. CSF-1R expression has been until now mainly described at a steady state in monocytes\/macrophages and myeloid dendritic cells, as well as in some cancers. IL-34 has also 2 other receptors, protein-tyrosine phosphatase zeta (PTP\u03b6) and CD138 (Syndecan-1), expressed in some epithelium, cells of the central nervous system (CNS), as well as in numerous cancers. While most, if not all, of CSF-1 actions are mediated through monocyte\/macrophages, IL-34 has also other potential actions through PTP\u03b6 and CD138. Additionally, IL-34 and CSF-1 are produced by different cells in different tissues. This review describes and discusses similarities and differences between IL-34 and CSF-1 at steady state and in pathological situations and identifies possible ways to target IL-34, CSF-1, and its receptors.<\/jats:p>","DOI":"10.1002\/jlb.3ru1120-773r","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:15:19Z","timestamp":1613852119000},"page":"771-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["IL-34 and CSF-1, deciphering similarities and differences at steady state and in diseases"],"prefix":"10.1093","volume":"110","author":[{"given":"Antoine","family":"Freuchet","sequence":"first","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes, France"},{"name":"Institut de Transplantation Urologie N\u00e9phrologie (ITUN), CHU Nantes , Nantes, France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d , Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apolline","family":"Salama","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes, France"},{"name":"Institut de Transplantation Urologie N\u00e9phrologie (ITUN), CHU Nantes , Nantes, France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d , Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Remy","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes, France"},{"name":"Institut de Transplantation Urologie N\u00e9phrologie (ITUN), CHU Nantes , Nantes, France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d , Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Guillonneau","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes, France"},{"name":"Institut de Transplantation Urologie N\u00e9phrologie (ITUN), CHU Nantes , Nantes, France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d , Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Anegon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Universit\u00e9 de Nantes , Nantes, France"},{"name":"Institut de Transplantation Urologie N\u00e9phrologie (ITUN), CHU Nantes , Nantes, France"},{"name":"LabEx IGO \u201cImmunotherapy, Graft, Oncology\u201d , Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1084\/jem.143.3.631","article-title":"Factors regulating macrophage production and growth: identity of colony-stimulating factor and macrophage growth factor","volume":"143","author":"Stanley","year":"1976","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"a021857","DOI":"10.1101\/cshperspect.a021857","article-title":"CSF-1 Receptor Signaling in Myeloid Cells","volume":"6","author":"Stanley","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.1154370","article-title":"Discovery of a cytokine and its receptor by functional screening of the extracellular proteome","volume":"320","author":"Lin","year":"2008","journal-title":"Science"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1074\/jbc.M112.442731","article-title":"Receptor-type protein-tyrosine phosphatase \u03b6 is a functional receptor for interleukin-34","volume":"288","author":"Nandi","year":"2013","journal-title":"J Biol Chem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1172\/JCI81166","article-title":"IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease","volume":"125","author":"Baek","year":"2015","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bbamcr.2015.01.023","article-title":"Syndecan-1 regulates the biological activities of interleukin-34","volume":"1853","author":"Segaliny","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2023032108462929200_","first-page":"177","article-title":"CD138 (syndecan-1) expression in health and disease","volume":"29","author":"Palaiologou","year":"2014","journal-title":"Histol Histopathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00018-017-2482-4","article-title":"Immunoregulatory properties of the cytokine IL-34","volume":"74","author":"Guillonneau","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/JLB.MR1117-457R","article-title":"Interleukin-34, a comprehensive review","volume":"104","author":"Baghdadi","year":"2018","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00774-013-0476-3","article-title":"IL-34 and CSF-1: similarities and differences","volume":"31","author":"Nakamichi","year":"2013","journal-title":"J Bone Miner Metab"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.bbapap.2012.04.012","article-title":"The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1","volume":"1824","author":"Liu","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.str.2012.02.010","article-title":"Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R","volume":"20","author":"Ma","year":"2012","journal-title":"Structure"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.str.2013.01.018","article-title":"Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor","volume":"21","author":"Felix","year":"2013","journal-title":"Structure"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1455231","article-title":"Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor","volume":"258","author":"Pandit","year":"1992","journal-title":"Science"},{"key":"2023032108462929200_","first-page":"5348","article-title":"Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain","volume":"13","author":"Wang","year":"1993","journal-title":"Mol Cell Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/mt.2014.112","article-title":"Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor","volume":"22","author":"Gow","year":"2014","journal-title":"Mol Ther"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1073\/pnas.84.17.6179","article-title":"Macrophages specifically regulate the concentration of their own growth factor in the circulation","volume":"84","author":"Bartocci","year":"1987","journal-title":"Proc Natl Acad Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.str.2011.10.012","article-title":"Extracellular Complexes of the Hematopoietic Human and Mouse CSF-1 Receptor Are Driven by Common Assembly Principles","volume":"19","author":"Elegheert","year":"2011","journal-title":"Structure"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1189\/jlb.1209822","article-title":"Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells","volume":"88","author":"Wei","year":"2010","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/S0021-9258(18)45861-9","article-title":"The predominant form of secreted colony stimulating factor-1 is a proteoglycan","volume":"267","author":"Price","year":"1992","journal-title":"J Biol Chem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.4049\/jimmunol.177.6.4055","article-title":"Distinct In Vivo Roles of Colony-Stimulating Factor-1 Isoforms in Renal Inflammation","volume":"177","author":"Jang","year":"2006","journal-title":"J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/cdd.2010.60","article-title":"IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation","volume":"17","author":"Chihara","year":"2010","journal-title":"Cell Death Differ"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41598-017-18433-4","article-title":"IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential","volume":"8","author":"Boulakirba","year":"2018","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/cdd.2010.60","article-title":"IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation","volume":"17","author":"Chihara","year":"2010","journal-title":"Cell Death Differ"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3389\/fimmu.2020.01496","article-title":"IL-34 Actions on FOXP3+ Tregs and CD14+ Monocytes Control Human Graft Rejection","volume":"11","author":"B\u00e9zie","year":"2020","journal-title":"Front Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e56045","DOI":"10.1371\/journal.pone.0056045","article-title":"IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFN\u03b3","volume":"8","author":"Foucher","year":"2013","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.4049\/jimmunol.175.3.1399","article-title":"The Colony-Stimulating Factor 1 Receptor Is Expressed on Dendritic Cells during Differentiation and Regulates Their Expansion","volume":"175","author":"MacDonald","year":"2005","journal-title":"J Immunol"},{"key":"2023032108462929200_","first-page":"371","article-title":"Expression of the colony-stimulating factor 1 receptor in B lymphocytes","volume":"8","author":"Baker","year":"1993","journal-title":"Oncogene"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/eji.201344365","article-title":"Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells: highlights","volume":"44","author":"Wang","year":"2014","journal-title":"Eur J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.7150\/jca.28231","article-title":"The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: a Review and Bioinformatic Analysis","volume":"10","author":"Xia","year":"2019","journal-title":"J Cancer"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2009.01.025","article-title":"A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies","volume":"201","author":"Lafont","year":"2009","journal-title":"Behav Brain Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(98)00295-X","article-title":"Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase \u03b6\/RPTP\u03b2: analysis of mice in which the PTP\u03b6\/RPTP\u03b2 gene was replaced with the LacZ gene","volume":"247","author":"Shintani","year":"1998","journal-title":"Neurosci Lett"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0165-3806(93)90035-9","article-title":"The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system","volume":"75","author":"Canoll","year":"1993","journal-title":"Dev Brain Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/wound.2014.0555","article-title":"Syndecan-1 and Its Expanding List of Contacts","volume":"4","author":"Stepp","year":"2015","journal-title":"Adv Wound Care"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.immuni.2012.11.001","article-title":"Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia","volume":"37","author":"Greter","year":"2012","journal-title":"Immunity"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ni.2360","article-title":"IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia","volume":"13","author":"Wang","year":"2012","journal-title":"Nat Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1084\/jem.20182037","article-title":"CSF-1 controls cerebellar microglia and is required for motor function and social interaction","volume":"216","author":"Kana","year":"2019","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1172\/JCI81227","article-title":"IL-34 is a Treg-specific cytokine and mediates transplant tolerance","volume":"125","author":"B\u00e9zie","year":"2015","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nri2356","article-title":"Colony-stimulating factors in inflammation and autoimmunity","volume":"8","author":"Hamilton","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cyto.2015.05.029","article-title":"IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization","volume":"76","author":"S\u00e9galiny","year":"2015","journal-title":"Cytokine"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/330484a0","article-title":"Apparent role of the macrophage growth factor, CSF-1, in placental development","volume":"330","author":"Pollard","year":"1987","journal-title":"Nature"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/humrep\/dey037","article-title":"Interleukin-34 is present at the fetal-maternal interface and induces immunoregulatory macrophages of a decidual phenotype in vitro","volume":"33","author":"Lindau","year":"2018","journal-title":"Hum Reprod"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.4049\/jimmunol.141.10.3405","article-title":"The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo","volume":"141","author":"Hume","year":"1988","journal-title":"J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/path.2684","article-title":"Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis","volume":"221","author":"Baud'huin","year":"2010","journal-title":"J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1523-1747.2003.12036.x","article-title":"Macrophage Colony-stimulating Factor in Cooperation with Transforming Growth Factor-\u03b21 Induces the Differentiation of CD34+ Hematopoietic Progenitor Cells Into Langerhans Cells Under Serum-free Conditions Without Granulocyte-macrophage Colony-stimulating Factor","volume":"120","author":"Mollah","year":"2003","journal-title":"J Invest Dermatol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"Dai","year":"2002","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.4049\/jimmunol.1701783","article-title":"Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus","volume":"201","author":"Pridans","year":"2018","journal-title":"J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and macrophages in brain homeostasis and disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.immuni.2019.02.007","article-title":"Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration","volume":"50","author":"O'Koren","year":"2019","journal-title":"Immunity"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41380-019-0609-8","article-title":"Microglial regional heterogeneity and its role in the brain","volume":"25","author":"Tan","year":"2020","journal-title":"Mol Psychiatry"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ydbio.2012.03.026","article-title":"The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation","volume":"367","author":"Nandi","year":"2012","journal-title":"Dev Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(98)00618-0","article-title":"Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op\/op mice","volume":"804","author":"W\u0119giel","year":"1998","journal-title":"Brain Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1440-1789.2000.00286.x","article-title":"Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor","volume":"20","author":"Sasaki","year":"2000","journal-title":"Neuropathology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tins.2016.03.005","article-title":"Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System","volume":"39","author":"Chitu","year":"2016","journal-title":"Trends Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.devcel.2018.08.005","article-title":"Il34-Csf1r Pathway Regulates the Migration and Colonization of Microglial Precursors","volume":"46","author":"Wu","year":"2018","journal-title":"Dev Cell"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"dmm037762","DOI":"10.1242\/dmm.037762","article-title":"Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain","volume":"12","author":"Kuil","year":"2019","journal-title":"Dis Model Mech"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-008-0586-8","article-title":"Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op\/op) mice after macrophage depletion","volume":"332","author":"Yamamoto","year":"2008","journal-title":"Cell Tissue Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-017-1747-1","article-title":"Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood","volume":"134","author":"Hagemeyer","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/cells9010099","article-title":"Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination","volume":"9","author":"Wylot","year":"2019","journal-title":"Cells"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1073\/pnas.1802490115","article-title":"Muscularis macrophage development in the absence of an enteric nervous system","volume":"115","author":"Avetisyan","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s004410051254","article-title":"Op\/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine","volume":"295","author":"Mikkelsen","year":"1999","journal-title":"Cell Tissue Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.autneu.2012.02.004","article-title":"Macrophages Associated with the Intrinsic and Extrinsic Autonomic Innervation of the Rat Gastrointestinal Tract","volume":"169","author":"Phillips","year":"2012","journal-title":"Auton Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/B:HIJO.0000039840.86420.b7","article-title":"Macrophages in the Small Intestinal Muscularis Externa of Embryos, Newborn and Adult Germ-Free Mice","volume":"35","author":"Mikkelsen","year":"2003","journal-title":"Histochem J"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1084\/jem.156.5.1516","article-title":"Hematological characterization of congenital osteopetrosis in op\/op mouse. Possible mechanism for abnormal macrophage differentiation","volume":"156","author":"Wiktor-Jedrzejczak","year":"1982","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0012-1606(91)90336-2","article-title":"A pregnancy defect in the osteopetrotic (op\/op) mouse demonstrates the requirement for CSF-1 in female fertility","volume":"148","author":"Pollard","year":"1991","journal-title":"Dev Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0040-8166(97)80059-6","article-title":"The effects of colony-stimulating factor-1 on the number and ultrastructure of osteoclasts in toothless (tl) rats and osteopetrotic (op) mice","volume":"29","author":"Marks","year":"1997","journal-title":"Tissue Cell"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1073\/pnas.202332999","article-title":"The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification","volume":"99","author":"Van Wesenbeeck","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1212\/WNL.0000000000006642","article-title":"CSF1R -related leukoencephalopathy: a major player in primary microgliopathies","volume":"91","author":"Konno","year":"2018","journal-title":"Neurology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ajhg.2019.03.004","article-title":"Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation","volume":"104","author":"Guo","year":"2019","journal-title":"The Am J Human Genet"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jns.2016.06.013","article-title":"A family with hereditary diffuse leukoencephalopathy with spheroids caused by a novel c.2442+2T&gt;C mutation in the CSF1R gene","volume":"367","author":"Kawakami","year":"2016","journal-title":"J Neurol Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.parkreldis.2017.08.018","article-title":"Cognitive dysfunction and symptoms of movement disorders in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia","volume":"46","author":"Ikeuchi","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"104867","DOI":"10.1016\/j.nbd.2020.104867","article-title":"Altered features of monocytes in adult onset leukoencephalopathy with axonal spheroids and pigmented glia: a clue to the pathomechanism of microglial dyshomeostasis","volume":"140","author":"Hamatani","year":"2020","journal-title":"Neurobiol Dis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood-2011-09-379214","article-title":"Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling","volume":"119","author":"Hume","year":"2012","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41598-017-18796-8","article-title":"High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers","volume":"8","author":"Baghdadi","year":"2018","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1007\/s13277-014-2627-0","article-title":"Macrophage colony-stimulating factor and cancer: a review","volume":"35","author":"Chockalingam","year":"2014","journal-title":"Tumor Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3390\/cancers12010252","article-title":"Role of Interleukin-34 in Cancer","volume":"12","author":"Franz\u00e8","year":"2020","journal-title":"Cancers"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3892\/ijmm.2014.2001","article-title":"Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction","volume":"35","author":"Wang","year":"2015","journal-title":"Int J Mol Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/1724600817748879","article-title":"Genetic variants in macrophage colony-stimulating factor are associated with risk of renal cell carcinoma in a Chinese population","volume":"33","author":"Li","year":"2018","journal-title":"Int J Biol Markers"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e59688","DOI":"10.1371\/journal.pone.0059688","article-title":"SNP-SNP Interaction Network in Angiogenesis Genes Associated with Prostate Cancer Aggressiveness","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/1479-7364-2-5-287","article-title":"Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations","volume":"2","author":"Savas","year":"2006","journal-title":"Hum Genomics"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1182\/bloodadvances.2018020008","article-title":"A role for IL-34 in osteolytic disease of multiple myeloma","volume":"3","author":"Baghdadi","year":"2019","journal-title":"Blood Adv"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ijc.29376","article-title":"Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment","volume":"137","author":"S\u00e9galiny","year":"2015","journal-title":"Int J Cancer"},{"key":"2023032108462929200_","first-page":"1","article-title":"Interleukin-34 induces monocytic-like differentiation in leukemia cell lines","volume":"6","author":"Booker","year":"2015","journal-title":"Int J Biochem Mol Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3960\/jslrt.18034","article-title":"Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia\/lymphoma","volume":"58","author":"Komohara","year":"2018","journal-title":"JCEH"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1074","article-title":"Expression of il -34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma","volume":"8","author":"Noyori","year":"2019","journal-title":"Clin Transl Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1074\/jbc.RA118.006226","article-title":"Interleukin 34 (IL-34) cell-surface localization regulated by the molecular chaperone 78-kDa glucose-regulated protein facilitates the differentiation of monocytic cells","volume":"294","author":"Ogawa","year":"2019","journal-title":"J Biol Chem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13578-020-00454-8","article-title":"Inverse correlation between Interleukin-34 and gastric cancer, a potential biomarker for prognosis","volume":"10","author":"Liu","year":"2020","journal-title":"Cell Biosci"},{"key":"2023032108462929200_","first-page":"737","article-title":"Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer","volume":"53","author":"Okugawa","year":"2018","journal-title":"Int J Oncol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/25785826.2019.1691429","article-title":"Prognostic value of IL-34 in colorectal cancer patients","volume":"42","author":"Kobayashi","year":"2019","journal-title":"Immunol Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.18632\/oncotarget.23289","article-title":"Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue","volume":"9","author":"Franz\u00e8","year":"2017","journal-title":"Oncotarget"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02019","article-title":"Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer","volume":"10","author":"Lin","year":"2019","journal-title":"Front Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23335","article-title":"IL-34 is a potential biomarker for the treatment of papillary thyroid cancer","volume":"34","author":"Zhang","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fendo.2018.00629","article-title":"IL-34 Expression Is Reduced in Hashimoto's Thyroiditis and Associated With Thyrocyte Apoptosis","volume":"9","author":"Wang","year":"2018","journal-title":"Front Endocrinol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3803\/EnM.2013.28.3.178","article-title":"The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma","volume":"28","author":"Kim","year":"2013","journal-title":"Endocrinol Metab"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e54302","DOI":"10.1371\/journal.pone.0054302","article-title":"Genetic and Pharmacological Targeting of CSF-1\/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression","volume":"8","author":"Ryder","year":"2013","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120422","article-title":"The RUNX1\/IL-34\/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma","volume":"3","author":"Giricz","year":"2018","journal-title":"JCI Insight"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1158\/0008-5472.CAN-16-1170","article-title":"Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells","volume":"76","author":"Baghdadi","year":"2016","journal-title":"Cancer Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13045-020-00887-1","article-title":"Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer","volume":"13","author":"Lu","year":"2020","journal-title":"J Hematol Oncol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1021\/acs.jmedchem.7b00873","article-title":"Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors","volume":"61","author":"El-Gamal","year":"2018","journal-title":"J Med Chem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"23126","DOI":"10.18632\/oncotarget.25226","article-title":"Differential prognostic impact of interleukin-34 mRNA expression and infiltrating immune cell composition in intrinsic breast cancer subtypes","volume":"9","author":"Zins","year":"2018","journal-title":"Oncotarget"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1007\/s12282-020-01123-x","article-title":"Interleukin-34 contributes to poor prognosis in triple-negative breast cancer","volume":"27","author":"Kajihara","year":"2020","journal-title":"Breast Cancer"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/2326-6066.CIR-13-0190","article-title":"The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R\/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor","volume":"2","author":"Swierczak","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97792","article-title":"CSF1R-dependent myeloid cells are required for NK\u2011mediated control of metastasis","volume":"3","author":"Beffinger","year":"2018","journal-title":"JCI Insight"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/intimm\/dxz074","article-title":"Interleukin-34 expression in ovarian cancer: a possible correlation with disease progression","volume":"32","author":"Endo","year":"2020","journal-title":"Int Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BST20150245","article-title":"Role of the colony-stimulating factor (CSF)\/CSF-1 receptor axis in cancer","volume":"44","author":"Achkova","year":"2016","journal-title":"Biochem Soc Trans"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/eji.201444606","article-title":"IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1\u03b1","volume":"45","author":"Foucher","year":"2015","journal-title":"Eur J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1200\/JCO.2007.15.6521","article-title":"High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma","volume":"26","author":"Zhu","year":"2008","journal-title":"JCO"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/hepr.13350","article-title":"High serum interleukin-34 level is a predictor of poor prognosis in patients with non-viral hepatocellular carcinoma","volume":"49","author":"Noda","year":"2019","journal-title":"Hepatol Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.28445","article-title":"miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis","volume":"63","author":"Zhou","year":"2016","journal-title":"Hepatology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13045-015-0150-4","article-title":"microRNA-26a suppresses recruitment of macrophages by down-regulating macrophage colony-stimulating factor expression through the PI3K\/Akt pathway in hepatocellular carcinoma","volume":"8","author":"Chai","year":"2015","journal-title":"J Hematol Oncol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"109523","DOI":"10.1016\/j.biopha.2019.109523","article-title":"MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis","volume":"120","author":"Ke","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12703","article-title":"Interleukin-34 mediated by hepatitis B virus X protein via CCAAT\/enhancer-binding protein \u03b1 contributes to the proliferation and migration of hepatoma cells","volume":"52","author":"Kong","year":"2019","journal-title":"Cell Prolif"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000182","article-title":"Involvement of the M-CSF\/IL-34\/CSF-1R pathway in malignant pleural mesothelioma","volume":"8","author":"Blondy","year":"2020","journal-title":"J Immunother Cancer"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jnr.20485","article-title":"Microglia function in brain tumors","volume":"81","author":"Watters","year":"2005","journal-title":"J Neurosci Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1158\/0008-5472.CAN-09-4674","article-title":"Sleeping Beauty \u2013Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas","volume":"70","author":"Bender","year":"2010","journal-title":"Cancer Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cas.12314","article-title":"Clinical significance of macrophage heterogeneity in human malignant tumors","volume":"105","author":"Komohara","year":"2014","journal-title":"Cancer Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1158\/0008-5472.CAN-15-2386","article-title":"CSF1 overexpression promotes high-grade glioma formation without impacting the polarization status of glioma-associated microglia and macrophages","volume":"76","author":"De","year":"2016","journal-title":"Cancer Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/path.2370","article-title":"Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas","volume":"216","author":"Komohara","year":"2008","journal-title":"J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2119\/molmed.2011.00217","article-title":"Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling","volume":"18","author":"Coniglio","year":"2012","journal-title":"Mol Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nm.3337","article-title":"CSF-1R inhibition alters macrophage polarization and blocks glioma progression","volume":"19","author":"Pyonteck","year":"2013","journal-title":"Nat Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"eaaw7843","DOI":"10.1126\/scitranslmed.aaw7843","article-title":"Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance","volume":"12","author":"Akkari","year":"2020","journal-title":"Sci Transl Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00428-018-2503-1","article-title":"M-CSF and IL-34 expression as indicators for growth in sporadic vestibular schwannoma","volume":"474","author":"de Vries","year":"2019","journal-title":"Virchows Arch"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1172\/JCI116179","article-title":"Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors","volume":"91","author":"Tanaka","year":"1993","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1136\/ard.2006.054874","article-title":"Increased expression of macrophage colony-stimulating factor in ankylosing spondylitis and rheumatoid arthritis","volume":"65","author":"Yang","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/annrheumdis-2011-200096","article-title":"Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients","volume":"71","author":"Chemel","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ajpath.2016.09.015","article-title":"Bone Morphogenetic Protein 2 and Transforming Growth Factor \u03b21 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts","volume":"187","author":"Chemel","year":"2017","journal-title":"Am J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/ar3693","article-title":"Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis","volume":"14","author":"Hwang","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1172\/JCI26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1189\/jlb.68.1.144","article-title":"The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF","volume":"68","author":"Campbell","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1089\/jir.2017.0095","article-title":"Interleukin-34 Aggravates the Severity of Arthritis in Collagen-Induced Arthritis Mice by Inducing Interleukin-17 Production","volume":"38","author":"Zhang","year":"2018","journal-title":"J Interferon Cytokine Res"},{"key":"2023032108462929200_","first-page":"479","article-title":"IL-34 modulates rheumatoid synovial fibroblasts proliferation and migration via ERK\/AKT signalling pathway","volume":"38","author":"Elkhider","journal-title":"Clin Exp Rheumatol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3899\/jrheum.151253","article-title":"Interleukin 34 Upregulation Contributes to the Increment of MicroRNA 21 Expression through STAT3 Activation Associated with Disease Activity in Rheumatoid Arthritis","volume":"43","author":"Yang","year":"2016","journal-title":"J Rheumatol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcb.21331","article-title":"Multiple roles of M-CSF in human osteoclastogenesis","volume":"102","author":"Hodge","year":"2007","journal-title":"J Cell Biochem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1902\/jop.2017.170081","article-title":"Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease","volume":"88","author":"Martinez","year":"2017","journal-title":"J Periodontol"},{"key":"2023032108462929200_","first-page":"652","article-title":"Expression of cytokines Il-6, IL-34 and M-CSFR in chronic periodontitis and its clinical significance","volume":"27","author":"Luo","year":"2018","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13075-016-0973-6","article-title":"Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis","volume":"18","author":"Garcia","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2023032108462929200_","first-page":"37","article-title":"New Interleukins in Psoriasis and Psoriatic Arthritis Patients: the Possible Roles of Interleukin-33 to Interleukin-38 in Disease Activities and Bone Erosions","volume":"233","author":"Li","year":"2017","journal-title":"DRM"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1172\/JCI39087","article-title":"CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice","volume":"119","author":"Menke","year":"2009","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ki.2015.295","article-title":"Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury","volume":"88","author":"Wang","year":"2015","journal-title":"Kidney Int"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1172\/JCI60363","article-title":"CSF-1 signaling mediates recovery from acute kidney injury","volume":"122","author":"Zhang","year":"2012","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ajpath.2011.05.037","article-title":"Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses","volume":"179","author":"Alikhan","year":"2011","journal-title":"Am J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4928315","article-title":"Prevalence of Syndecan-1 (CD138) Expression in Different Kinds of Human Tumors and Normal Tissues","volume":"2019","author":"Kind","year":"2019","journal-title":"Dis Markers"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ki.2011.425","article-title":"Tubular epithelial syndecan-1 maintains renal function in murine ischemia\/reperfusion and human transplantation","volume":"81","author":"Celie","year":"2012","journal-title":"Kidney Int"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2353\/ajpath.2007.061191","article-title":"Macrophage Colony-Stimulating Factor Improves Cardiac Function after Ischemic Injury by Inducing Vascular Endothelial Growth Factor Production and Survival of Cardiomyocytes","volume":"171","author":"Okazaki","year":"2007","journal-title":"Am J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"G390","DOI":"10.1152\/ajpgi.00137.2019","article-title":"Fibrotic liver has prompt recovery after ischemia-reperfusion injury","volume":"318","author":"Konishi","year":"2020","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e77489","DOI":"10.1371\/journal.pone.0077489","article-title":"Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks","volume":"8","author":"Bethunaickan","year":"2013","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1681\/ASN.2013121356","article-title":"Colony-stimulating factor-1: a potential biomarker for lupus nephritis","volume":"26","author":"Menke","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1681\/ASN.2018090901","article-title":"IL-34-Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice","volume":"30","author":"Wada","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.4049\/jimmunol.181.10.7367","article-title":"Sunlight Triggers Cutaneous Lupus through a CSF-1-Dependent Mechanism in MRL- Fas lpr Mice","volume":"181","author":"Menke","year":"2008","journal-title":"J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1681\/ASN.2009050499","article-title":"Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis","volume":"20","author":"Menke","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaut.2014.11.007","article-title":"Macrophage depletion ameliorates nephritis induced by pathogenic antibodies","volume":"57","author":"Chalmers","year":"2015","journal-title":"J Autoimmun"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1038\/s41598-018-21859-z","article-title":"Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity","volume":"8","author":"Xie","year":"2018","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/ndt\/gfh257","article-title":"Serum levels of macrophage-colony stimulating factor (M-CSF): a marker of kidney allograft rejection","volume":"19","author":"Le Meur","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fimmu.2017.02014","article-title":"Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow\/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice","volume":"8","author":"B\u00e9zie","year":"2017","journal-title":"Front Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e265","DOI":"10.1097\/TP.0000000000002194","article-title":"IL-34 Inhibits Acute Rejection of Rat Liver Transplantation by Inducing Kupffer Cell M2 Polarization","volume":"102","author":"Zhao","year":"2018","journal-title":"Transplantation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"eaav8075","DOI":"10.1126\/scitranslmed.aav8075","article-title":"Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure","volume":"12","author":"Arnold","year":"2020","journal-title":"Sci Transl Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10753-012-9582-y","article-title":"Sdc1 Overexpression Inhibits the p38 MAPK Pathway and Lessens Fibrotic Ventricular Remodeling in MI Rats","volume":"36","author":"Lei","year":"2013","journal-title":"Inflammation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/SHK.0000000000000329","article-title":"Impairment of the Endothelial Glycocalyx in Cardiogenic Shock and its Prognostic Relevance","volume":"43","author":"Jung","year":"2015","journal-title":"Shock"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.1038\/s41598-019-54937-x","article-title":"Syndecan-1 Predicts Outcome in Patients with ST-Segment Elevation Infarction Independent from Infarct-related Myocardial Injury","volume":"9","author":"Wernly","year":"2019","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1034\/j.1399-3089.2003.01142.x","article-title":"Xenogeneic skin graft rejection in M-CSF\/macrophage deficient osteopetrotic mice","volume":"10","author":"Zhao","year":"2003","journal-title":"Xenotransplantation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01.TP.0000100483.41935.B5","article-title":"Macrophage colony-stimulating factor inhibits tumor necrosis factor production and prolongs skin graft survival","volume":"77","author":"Nishina","year":"2004","journal-title":"Transplantation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/mt.2012.168","article-title":"IFN-\u03b3-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients","volume":"21","author":"Riquelme","year":"2013","journal-title":"Mol Ther"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.immuni.2015.05.009","article-title":"DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance","volume":"42","author":"Conde","year":"2015","journal-title":"Immunity"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1189\/jlb.70.1.39","article-title":"Effects of macrophage-CSF on pulmonary-macrophage repopulation after bone marrow transplantation","volume":"70","author":"Bernier","year":"2001","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20101709","article-title":"Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation","volume":"208","author":"Hashimoto","year":"2011","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1084\/jem.20151975","article-title":"M-CSF improves protection against bacterial and fungal infections after hematopoietic stem\/progenitor cell transplantation","volume":"213","author":"Kandalla","year":"2016","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1182\/blood.V79.6.1636.1636","article-title":"Effect of recombinant human macrophage colony-stimulating factor in irradiated murine recipients of T-cell-depleted allogeneic or non-depleted syngeneic bone marrow transplants","volume":"79","author":"Blazar","year":"1992","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"S407","DOI":"10.1097\/01.tp.0000543180.86070.24","article-title":"M-CSF and TNF-\u03b1 Induce Human MDSCs that Attenuate GVHD","volume":"102","author":"Puxun","year":"2018","journal-title":"Transplantation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2141.1990.tb07907.x","article-title":"Double-blind test of human urinary macrophage colony-stimulating factor for allogeneic and syngeneic bone marrow transplantation: effectiveness of treatment and 2-year follow-up for relapse of leukaemia","volume":"76","author":"Masaoka","year":"1990","journal-title":"Br J Haematol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/bmt.2011.90","article-title":"M-CSF attenuates severity of chronic GVHD after unrelated BMT","volume":"47","author":"Kimura","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1182\/blood.V78.4.907.907","article-title":"Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections","volume":"78","author":"Nemunaitis","year":"1991","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S1499-3872(14)60024-2","article-title":"Inflammatory response of macrophages in infection","volume":"13","author":"Zhang","year":"2014","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jss.2009.10.023","article-title":"Role of Macrophage Colony-Stimulating Factor in Polymicrobial Sepsis According to Studies Using Osteopetrotic (op\/op) Mice","volume":"169","author":"Ogiku","year":"2011","journal-title":"J Surg Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e584","DOI":"10.1097\/CCM.0000000000003017","article-title":"Interleukin-34 Ameliorates Survival and Bacterial Clearance in Polymicrobial Sepsis*","volume":"46","author":"Lin","year":"2018","journal-title":"Crit Care Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/hep.27328","article-title":"IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells","volume":"60","author":"Preisser","year":"2014","journal-title":"Hepatology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e0179605","DOI":"10.1371\/journal.pone.0179605","article-title":"Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo","volume":"12","author":"Cheng","year":"2017","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cyto.2018.09.006","article-title":"Human interleukin-34-derived macrophages have increased resistance to HIV-1 infection","volume":"111","author":"Paquin-Proulx","year":"2018","journal-title":"Cytokine"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3748\/wjg.v24.i12.1312","article-title":"Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection","volume":"24","author":"Wang","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jnen\/nlx115","article-title":"Increased Microglial CSF1R Expression in the SIV\/Macaque Model of HIV CNS Disease","volume":"77","author":"Knight","year":"2018","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.4049\/jimmunol.164.9.4955","article-title":"Macrophage Colony-Stimulating Factor Antagonists Inhibit Replication of HIV-1 in Human Macrophages","volume":"164","author":"Kutza","year":"2000","journal-title":"J Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1189\/jlb.4AB0315-117RR","article-title":"Distinct functional roles of amphibian (Xenopus laevis) colony-stimulating factor-1- and interleukin-34-derived macrophages","volume":"98","author":"Grayfer","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/JLB.1A0919-147R","article-title":"Colony-stimulating factor-1- and interleukin-34-derived macrophages differ in their susceptibility to Mycobacterium marinum","volume":"106","author":"Popovic","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.dci.2019.04.011","article-title":"The amphibian (Xenopus laevis) colony-stimulating factor-1 and interleukin-34-derived macrophages possess disparate pathogen recognition capacities","volume":"98","author":"Yaparla","year":"2019","journal-title":"Developmental & Comparative Immunology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1074\/jbc.M117.794065","article-title":"Differentiation-dependent antiviral capacities of amphibian (Xenopus laevis) macrophages","volume":"293","author":"Yaparla","year":"2018","journal-title":"J Biol Chem"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1089\/1079990041535638","article-title":"Colony-Stimulating Factor-1 Promotes Clonogenic Growth of Normal Murine Colonic Crypt Epithelial Cells In Vitro","volume":"24","author":"Ramsay","year":"2004","journal-title":"J Interferon Cytokine Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/CS20150132","article-title":"Interleukin-34 sustains inflammatory pathways in the gut","volume":"129","author":"Franz\u00e8","year":"2015","journal-title":"Clin Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/CS20150176","article-title":"Interleukin 34: a new modulator of human and experimental inflammatory bowel disease","volume":"129","author":"Zwicker","year":"2015","journal-title":"Clin Sci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ecco-jcc\/jjv181","article-title":"Interleukin-34 Induces Cc-chemokine Ligand 20 in Gut Epithelial Cells","volume":"10","author":"Franz\u00e8","year":"2016","journal-title":"J Crohn's Colitis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41598-017-00145-4","article-title":"CSF-1 regulates the function of monocytes in Crohn's disease patients in remission","volume":"7","author":"Nieto","year":"2017","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ibd.20055","article-title":"Blockade of colony stimulating factor-1 (CSF-1) leads to inhibition of DSS-induced colitis","volume":"13","author":"Marshall","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/ecco-jcc\/jjaa073","article-title":"Interleukin-34 Stimulates Gut Fibroblasts to Produce Collagen Synthesis","volume":"5","author":"Franz\u00e8","year":"2020","journal-title":"J Crohn's Colitis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.tins.2016.03.005","article-title":"Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System","volume":"39","author":"Chitu","year":"2016","journal-title":"Trends Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/glia.10120","article-title":"The relative number of macrophages\/microglia expressing macrophage colony-stimulating factor and its receptor decreases in multiple sclerosis lesions: m-CSF\/M-CSFR Expression in MS","volume":"40","author":"Werner","year":"2002","journal-title":"Glia"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1093\/hmg\/ddx315","article-title":"IKK\u03b2 and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD","volume":"26","author":"Khoshnan","year":"2017","journal-title":"Hum Mol Genet"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/1753425917725391","article-title":"1\u03b1,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells","volume":"23","author":"Zhang","year":"2017","journal-title":"Innate Immun"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.00019","article-title":"Neuron-Specific Vitamin D Signaling Attenuates Microglia Activation and CNS Autoimmunity","volume":"11","author":"Lee","year":"2020","journal-title":"Frontiers in Neurology"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0006-291X(02)02357-4","article-title":"Vitamin D3 and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells","volume":"297","author":"Zhu","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1523\/JNEUROSCI.4440-12.2013","article-title":"Regulation of Microglial Proliferation during Chronic Neurodegeneration","volume":"33","author":"Gomez-Nicola","year":"2013","journal-title":"J Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.3390\/ijms21207765","article-title":"Microglia in Prion Diseases: angels or Demons?","volume":"21","author":"Peggion","year":"2020","journal-title":"IJMS"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"579000","DOI":"10.3389\/fimmu.2020.579000","article-title":"Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration","volume":"11","author":"Obst","year":"2020","journal-title":"Front Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.20151000","article-title":"A neuroprotective role for microglia in prion diseases","volume":"213","author":"Zhu","year":"2016","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00244","article-title":"Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia","volume":"9","author":"Walker","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.ajpath.2011.06.011","article-title":"Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-\u03b2 Neurotoxicity","volume":"179","author":"Mizuno","year":"2011","journal-title":"Am J Pathol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1084\/jem.20120412","article-title":"Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival","volume":"210","author":"Luo","year":"2013","journal-title":"J Exp Med"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/brain\/awv379","article-title":"Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology","volume":"139","author":"Olmos-Alonso","year":"2016","journal-title":"Brain"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","article-title":"Injured sensory neuron\u2013derived CSF1 induces microglial proliferation and DAP12-dependent pain","volume":"19","author":"Guan","year":"2016","journal-title":"Nat Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/glia.23768","article-title":"Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis","volume":"68","author":"Trias","year":"2020","journal-title":"Glia"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbi.2017.10.023","article-title":"Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model","volume":"68","author":"Tang","year":"2018","journal-title":"Brain Behav Immun"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ng.1027","article-title":"Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids","volume":"44","author":"Rademakers","year":"2012","journal-title":"Nat Genet"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ajhg.2019.03.010","article-title":"Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia","volume":"104","author":"Oosterhof","year":"2019","journal-title":"The Am J Human Genet"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2014.12.001","article-title":"Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)","volume":"74","author":"Chitu","year":"2015","journal-title":"Neurobiol Dis"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1038\/srep25663","article-title":"CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves","volume":"6","author":"Mart\u00ednez-Muriana","year":"2016","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ana.10805","article-title":"Presence of dendritic cells, MCP-1, and activated microglia\/macrophages in amyotrophic lateral sclerosis spinal cord tissue: dendritic Cells and MCP-1 in ALS","volume":"55","author":"Henkel","year":"2004","journal-title":"Ann Neurol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2009.08.021","article-title":"Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase","volume":"220","author":"Gowing","year":"2009","journal-title":"Exp Neurol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"577062","DOI":"10.1016\/j.jneuroim.2019.577062","article-title":"Impact of interferon \u03b2-1b, interferon \u03b2-1a and fingolimod therapies on serum interleukins-22, 32\u03b1 and 34 concentrations in patients with relapsing-remitting multiple sclerosis","volume":"337","author":"Abdel-Dayem","year":"2019","journal-title":"J Neuroimmunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jneuroim.2008.01.015","article-title":"The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis","volume":"195","author":"Uemura","year":"2008","journal-title":"J Neuroimmunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1007\/s10875-011-9579-6","article-title":"Tyrosine Kinase Inhibitors Ameliorate Autoimmune Encephalomyelitis in a Mouse Model of Multiple Sclerosis","volume":"31","author":"Crespo","year":"2011","journal-title":"J Clin Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00523","article-title":"CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE","volume":"12","author":"Wlodarczyk","year":"2019","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e48797","DOI":"10.1371\/journal.pone.0048797","article-title":"Protein Tyrosine Phosphatase Receptor Type Z Negatively Regulates Oligodendrocyte Differentiation and Myelination","volume":"7","author":"Kuboyama","year":"2012","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/brain\/awr283","article-title":"Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot\u2013Marie\u2013Tooth disease type 1X","volume":"135","author":"Groh","year":"2012","journal-title":"Brain"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/glia.22796","article-title":"CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice: cx32-Deficient Schwann Cells and Macrophages","volume":"63","author":"Groh","year":"2015","journal-title":"Glia"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1523\/JNEUROSCI.3427-15.2016","article-title":"Cell-Surface and Secreted Isoforms of CSF-1 Exert Opposing Roles in Macrophage-Mediated Neural Damage in Cx32-Deficient Mice","volume":"36","author":"Groh","year":"2016","journal-title":"J Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1093\/brain\/awv240","article-title":"Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot\u2013Marie\u2013Tooth disease in mice","volume":"138","author":"Klein","year":"2015","journal-title":"Brain"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115981","article-title":"Interleukin-34 Restores Blood\u2013Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells","volume":"9","author":"Jin","year":"2014","journal-title":"PLoS One"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1167\/tvst.6.2.10","article-title":"Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy","volume":"6","author":"Ebneter","year":"2017","journal-title":"Trans Vis Sci Tech"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12974-018-1373-4","article-title":"Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation","volume":"15","author":"Kokona","year":"2018","journal-title":"J Neuroinflammation"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1034\/j.1600-0897.2002.1o035.x","article-title":"Increased Levels of Macrophage Colony-Stimulating Factor in the Placenta and Blood in Preeclampsia","volume":"47","author":"Hayashi","year":"2002","journal-title":"Am J Reprod Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2015.01.005","article-title":"Colony Stimulating Factors 1, 2, 3 and early pregnancy steps: from bench to bedside","volume":"109","author":"Rahmati","year":"2015","journal-title":"J Reprod Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1095\/biolreprod55.2.310","article-title":"Absence of Colony-Stimulating Factor-1 in Osteopetrotic (csfmoP\/csfmOP) Mice Results in Male Fertility Defects1","volume":"55","author":"Cohen","year":"1996","journal-title":"Biol Reprod"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/blood.V98.1.74","article-title":"Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)\/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis","volume":"98","author":"Ryan","year":"2001","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"16781","DOI":"10.1038\/s41598-019-52741-1","article-title":"Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R\/JAK3\/STAT6 signaling","volume":"9","author":"Lin","year":"2019","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0897.2004.00228.x","article-title":"Identification of the M-CSF Receptor in Endometriosis by Immunohistochemistry and RT-PCR: m-CSF receptor in endometriosis","volume":"52","author":"Mettler","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fertnstert.2008.09.050","article-title":"A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion","volume":"93","author":"Jensen","year":"2010","journal-title":"Fertil Steril"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.fertnstert.2011.03.026","article-title":"Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells","volume":"95","author":"Aligeti","year":"2011","journal-title":"Fertil Steril"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.fertnstert.2012.02.007","article-title":"Increased expression of macrophage colony\u2013stimulating factor and its receptor in patients with endometriosis","volume":"97","author":"Budrys","year":"2012","journal-title":"Fertil Steril"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e12330","DOI":"10.1111\/cpr.12330","article-title":"Co-culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells","volume":"50","author":"Chan","year":"2017","journal-title":"Cell Prolif"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"39324","DOI":"10.1038\/srep39324","article-title":"IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure","volume":"6","author":"Fan","year":"2016","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004911","article-title":"Prognostic Significance of Interleukin-34 (IL-34) in Patients With Chronic Heart Failure With or Without Renal Insufficiency","volume":"6","author":"Tao","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/ATVBAHA.119.311994","article-title":"Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease","volume":"39","author":"Mindur","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3389\/fphys.2018.00904","article-title":"Increased Serum Interleukin-34 Levels Are Related to the Presence and Severity of Cardiac Dysfunction in Patients With Ischemic Cardiomyopathy","volume":"9","author":"Xi","year":"2018","journal-title":"Front Physiol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"H483","DOI":"10.1152\/ajpheart.01016.2002","article-title":"MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype","volume":"285","author":"Frangogiannis","year":"2003","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1160\/TH09-06-0399","article-title":"Macrophage-modulating cytokines predict adverse outcome in heart failure","volume":"103","author":"Hohensinner","year":"2010","journal-title":"Thromb Haemost"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"17347","DOI":"10.1038\/s41598-018-35485-2","article-title":"IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK pathway","volume":"8","author":"Liu","year":"2018","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1172\/JCI2293","article-title":"Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth","volume":"101","author":"Levine","year":"1998","journal-title":"J Clin Invest"},{"key":"2023032108462929200_","first-page":"E1263","article-title":"IL-34 Is Associated with Obesity, Chronic Inflammation, and Insulin Resistance","volume":"99","author":"Chang","year":"2014","journal-title":"None"},{"key":"2023032108462929200_","first-page":"1","article-title":"The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications","author":"Zorena","year":"2016","journal-title":"Biomarkers"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"e12317","DOI":"10.1111\/jicd.12317","article-title":"Interleukin-34 levels in gingival crevicular fluid and plasma in periodontal health and disease with and without type-2 diabetes mellitus","volume":"9","author":"Guruprasad","year":"2018","journal-title":"J Investig Clin Dent"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1530\/EC-19-0436","article-title":"IL-34 causes inflammation and beta cell apoptosis and dysfunction in gestational diabetes mellitus","volume":"8","author":"Piao","year":"2019","journal-title":"Endocr Connect"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"28814","DOI":"10.1038\/srep28814","article-title":"Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease","volume":"6","author":"Shoji","year":"2016","journal-title":"Sci Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaci.2014.10.037","article-title":"Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection","volume":"135","author":"Esaki","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11912-017-0634-1","article-title":"CSF-1R Inhibitor Development: current Clinical Status","volume":"19","author":"Peyraud","year":"2017","journal-title":"Curr Oncol Rep"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fonc.2020.00188","article-title":"Tumor-Associated Macrophages: recent Insights and Therapies","volume":"10","author":"Zhou","year":"2020","journal-title":"Front Oncol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/neuonc\/nov245","article-title":"Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study","volume":"18","author":"Butowski","year":"2016","journal-title":"Neuro Oncol"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1182\/blood.V120.21.1638.1638","article-title":"CSF1R Inhibition by PLX3397 in Patients with Relapsed or Refractory Hodgkin Lymphoma: results From a Phase 2 Single Agent Clinical Trial","volume":"120","author":"Moskowitz","year":"2012","journal-title":"Blood"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1158\/1078-0432.CCR-14-1845","article-title":"An Open-Label, Multicenter, Phase I\/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma","volume":"21","author":"von Tresckow","year":"2015","journal-title":"Clin Cancer Res"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40425-017-0257-y","article-title":"Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy","volume":"5","author":"Cannarile","year":"2017","journal-title":"J Immunother Cancer"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrd.2016.231","article-title":"Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases","volume":"16","author":"Hamilton","year":"2017","journal-title":"Nat Rev Drug Discovery"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fncel.2015.00184","article-title":"Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders","volume":"9","author":"Ohgidani","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"2023032108462929200_","doi-asserted-by":"crossref","first-page":"1759091417716610","DOI":"10.1177\/1759091417716610","article-title":"Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells","volume":"9","author":"Amos","year":"2017","journal-title":"ASN Neuro"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.3RU1120-773R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.3RU1120-773R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/110\/4\/771\/49466599\/jlb10879.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/110\/4\/771\/49466599\/jlb10879.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T16:13:33Z","timestamp":1697904813000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/110\/4\/771\/6884601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":265,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2,18]]},"published-print":{"date-parts":[[2021,9,29]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.3ru1120-773r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"2020-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}