{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T08:25:44Z","timestamp":1698135944176},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1989,2,1]],"date-time":"1989-02-01T00:00:00Z","timestamp":602294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A chemotactic tetrapeptide from culture fluids of Staphylococcus aureus was purified to homogeneity by reverse-phase high-pressure liquid chromatography. The peptide comprises equimolar methionine, leucine, isoleucine, and phenylalanine. It inhibited binding of fluoresceinated fMet-Leu-Phe-Lys to human monocytes, which showed that it interacted with the formyl-methionyl peptide receptor and suggested that it was a formyl-methionyl peptide. Based on a comparison of dose-response curves for inhibition of fluoresceinated fMet-Leu-Phe-Lys binding, the relative affinity of the peptide for the receptor was comparable to that of fMet-Leu-Phe-Lys. At optimal concentrations, chemotactic efficacy (percentage of monocytes migrating to the attractant) was 53 \u00b1 4%, in contrast to 36 \u00b1 3% for the reference attractant fMet-Leu-Phe. Since approximately 60% of human monocytes have formyl-peptide receptors, the bacterial peptide is capable of attracting all receptor-bearing monocytes.<\/jats:p>","DOI":"10.1002\/jlb.45.2.114","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:33:16Z","timestamp":1515785596000},"page":"114-120","source":"Crossref","is-referenced-by-count":17,"title":["<i>Staphylococcus aureus<\/i> Tetrapeptide With High Chemotactic Potency and Efficacy for Human Leukocytes"],"prefix":"10.1093","volume":"45","author":[{"given":"Antal","family":"Rot","sequence":"first","affiliation":[{"name":"Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research Facility , Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis E","family":"Henderson","sequence":"additional","affiliation":[{"name":"Litton Bionetics Basic Research Program, Frederick Cancer Research Facility , Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Sowder","sequence":"additional","affiliation":[{"name":"Litton Bionetics Basic Research Program, Frederick Cancer Research Facility , Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J","family":"Leonard","sequence":"additional","affiliation":[{"name":"Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research Facility , Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,2,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.45.2.114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/45\/2\/114\/49719935\/jlb0114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/45\/2\/114\/49719935\/jlb0114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:50:38Z","timestamp":1680519038000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/45\/2\/114\/6978584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1989,2,1]]},"published-print":{"date-parts":[[1989,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.45.2.114","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1989,2]]},"published":{"date-parts":[[1989,2,1]]}}}