{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:09:16Z","timestamp":1770703756919,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human recombinant cachectin\/tumor necrosis factor (TNF) was shown to prime neutrophils (PMNs), in a dose-dependent fashion, for subsequent oxidative responsiveness toward n-formyl-methionyl-leucyl-phenylalanine (FMLP). One basis for this phenomenon appeared to be TNF-mediated FMLP receptor mobilization. The maximal observed priming response was associated with a nearly twofold increase in the expression of PMN FMLP surface receptors, without changes in receptor affinity. Priming was not seen following stimulation with phorbol myristate acetate, possibly eliminating a role for the protein kinase C-dependent transductional components of FMLP-induced oxidative activity in the priming process. FMLP receptor mobilization occurred without significant degranulation as evident by an absence of increased granular enzyme release. These data support a potential role of macrophage-derived TNF in the augmentation of PMN host-defense during infectious and inflammatory challenge. TNF-mediated PMN oxidative priming may also promote oxidant tissue injury as seen in septic shock, adult respiratory distress syndrome, and multiple system organ failure.<\/jats:p>","DOI":"10.1002\/jlb.47.3.217","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:31:56Z","timestamp":1515785516000},"page":"217-223","source":"Crossref","is-referenced-by-count":34,"title":["Activation of Neutrophils by Cachectin\/Tumor Necrosis Factor: Priming of N-Formyl-Methionyl-Leucyl-Phenylalanine-Induced Oxidative Responsiveness Via Receptor Mobilization Without Degranulation"],"prefix":"10.1093","volume":"47","author":[{"given":"Steven D","family":"Tennenberg","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Cincinnati College of Medicine , Cincinnati"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph S","family":"Solomkin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Cincinnati College of Medicine , Cincinnati"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,3,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.47.3.217","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/47\/3\/217\/49766283\/jlb0217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/47\/3\/217\/49766283\/jlb0217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T13:59:35Z","timestamp":1681221575000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/47\/3\/217\/6977711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1990,3,1]]},"published-print":{"date-parts":[[1990,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.47.3.217","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,3]]},"published":{"date-parts":[[1990,3,1]]}}}