{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T18:01:50Z","timestamp":1696183310332},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the presence of adenosine, formyl-Met-Leu-Phe-stimulated human neutrophils show a greatly diminished production of superoxide anion. Analysis of changes in levels of intracellular calcium revealed that the immediate increase (occurring within seconds) in intracellular calcium following addition of formyl-Met-Leu-Phe is not affected by the presence of adenosine, although there are significantly lower intracellular calcium levels during the late phase (occurring 1\u20134 min after addition of formyl-Met-Leu-Phe). Consistent with these findings is the fact that adenosine does not affect the production of inositol 1,4,5-trisphosphate in formyl-Met-Leu-Phe-stimulated neutrophils. These data suggest that the profound inhibitory effects of adenosine on superoxide responses in formyl-Met-Leu-Phe-stimulated neutrophils may be related to an action of adenosine occurring late in the sequence of events of signal transduction.<\/jats:p>","DOI":"10.1002\/jlb.48.3.281","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:31:39Z","timestamp":1515785499000},"page":"281-283","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Adenosine on Inositol 1,4,5-Trisphosphate Formation and Intracellular Calcium Changes in Formyl-Met-Leu-Phe-Stimulated Human Neutrophils"],"prefix":"10.1093","volume":"48","author":[{"given":"Blair A M","family":"Walker","sequence":"first","affiliation":[{"name":"Department of Pathology, The University of Michigan Medicial School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian E","family":"Hagenlocker","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Michigan Medicial School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonda K","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Michigan Medicial School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Michigan Medicial School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,9,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.48.3.281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/48\/3\/281\/49767104\/jlb0281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/48\/3\/281\/49767104\/jlb0281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T13:12:15Z","timestamp":1681218735000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/48\/3\/281\/6977673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1990,9,1]]},"published-print":{"date-parts":[[1990,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.48.3.281","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,9]]},"published":{"date-parts":[[1990,9,1]]}}}