{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T04:02:49Z","timestamp":1700539369315},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Histopathology revealed that nu\/nu mice developed both acute and chronic inflammatory responses following infection with Cryptococcus neoformans. In comparison to inflammatory responses in nu\/+ mice, the responses in nu\/nu mice were delayed, less intense, contained predominantly more polymorphonuclear leukocytes (PMNs) than macrophages (M\u03c6s), and did not develop into granulomas. In addition, nu\/nu mice developed cryptococcal skin lesions demonstrating that C. neoformans is dermatotropic in a T-cell deficient host. Quantitative culturing of infected organs confirmed that delayed and incomplete inflammatory responses observed in nu\/nu mice correlated with their enhanced susceptibility to C. neoformans.<\/jats:p>","DOI":"10.1002\/jlb.49.6.533","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:48:49Z","timestamp":1515786529000},"page":"533-541","source":"Crossref","is-referenced-by-count":12,"title":["Inflammatory Responses to Cryptococcosis in Congenitally Athymic Mice"],"prefix":"10.1093","volume":"49","author":[{"given":"Cindy A","family":"Salkowski","sequence":"first","affiliation":[{"name":"Medical Microbiology and Immunology , Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Balish","sequence":"additional","affiliation":[{"name":"University of Wisconsin Medical School, Departments of Surgery"},{"name":"Medical Microbiology and Immunology , Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,6,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.49.6.533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/49\/6\/533\/49767208\/jlb0533.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/49\/6\/533\/49767208\/jlb0533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T08:36:47Z","timestamp":1681202207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/49\/6\/533\/6977600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1991,6,1]]},"published-print":{"date-parts":[[1991,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.49.6.533","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,6]]},"published":{"date-parts":[[1991,6,1]]}}}