{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:28:49Z","timestamp":1792877329513,"version":"4.5.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aspergillus fumigatus (A. fumigatus) is an environmental fungus and a human pathogen. Neutrophils are critical effector cells during the fungal infections, and neutropenia is a risk factor for the development of pulmonary aspergillosis. Neutrophil extracellular traps (NETs) are released by neutrophils in response to A. fumigatus and inhibit the conidial germination. In this work, we observed that the receptors TLR2, TLR4, and Dectin-1 were dispensable for the A. fumigatus induced NET release. In contrast CD11b\/CD18 was critical for the NET release in response to A. fumigatus conidia, and this required the CD11b I-domain-mediated recognition, whereas the blockade of the CD11b lectin domain did not affect the A. fumigatus induced NET release. A. fumigatus induced NET release relied on the activity of spleen tyrosine kinase (Syk), Src family kinase(s), and class IA PI3 kinase \u03b4. Although A. fumigatus promoted histone citrullination, this process was dispensable for the NET release in response to A. fumigatus conidia. The A. fumigatus induced NET release required the reactive oxygen species generation by the NOX2 complex, in a downstream pathway requiring CD11b\/CD18, Src kinase family activity, Syk and PI3K class IA \u03b4. Our findings thus reveal the signaling pathways involved in the formation of NETs in response to A. fumigatus.<\/jats:p>","DOI":"10.1002\/jlb.4a0119-009rr","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T02:51:03Z","timestamp":1567479063000},"page":"69-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Mac-1 triggers neutrophil DNA extracellular trap formation to\n                    <i>Aspergillus fumigatus<\/i>\n                    independently of PAD4 histone citrullination"],"prefix":"10.1093","volume":"107","author":[{"given":"Juliana C.","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najara C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia A.","family":"Thompson-Souza","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdirene de S.","family":"Muniz","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane S.","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo T.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Campus de Duque de Caxias, Universidade Federal do Rio de Janeiro , Duque de Caxias, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"2023012312510264200_jlb10482-bib-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MCP.0b013e32835f1ad1","article-title":"Frequency, diagnosis and management of fungal respiratory infections","volume":"19","author":"Hayes","year":"2013","journal-title":"Curr Opin Pulm Med"},{"key":"2023012312510264200_jlb10482-bib-0002","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0966-842X(01)02104-7","article-title":"The pathobiology of Aspergillus fumigatus","volume":"9","author":"Latg\u00e9","year":"2001","journal-title":"Trends Microbiol"},{"key":"2023012312510264200_jlb10482-bib-0003","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.4049\/jimmunol.176.6.3717","article-title":"Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states","volume":"176","author":"Gersuk","year":"2006","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0004","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1371\/journal.ppat.0010030","article-title":"Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display","volume":"1","author":"Hohl","year":"2005","journal-title":"PLoS Pathog"},{"key":"2023012312510264200_jlb10482-bib-0005","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1371\/journal.ppat.0010042","article-title":"The beta-glucan receptor Dectin-1 recognizes specific morphologies of Aspergillus fumigatus","volume":"1","author":"Steele","year":"2005","journal-title":"PLoS Pathog"},{"key":"2023012312510264200_jlb10482-bib-0006","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1462-5822.2003.00301.x","article-title":"Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages","volume":"5","author":"Meier","year":"2003","journal-title":"Cell Microbiol"},{"key":"2023012312510264200_jlb10482-bib-0007","doi-asserted-by":"crossref","first-page":"39320","DOI":"10.1074\/jbc.M201683200","article-title":"Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus","volume":"277","author":"Mambula","year":"2002","journal-title":"J Biol Chem"},{"key":"2023012312510264200_jlb10482-bib-0008","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores","volume":"460","author":"Aimanianda","year":"2009","journal-title":"Nature"},{"key":"2023012312510264200_jlb10482-bib-0009","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/35092620","article-title":"Immune recognition. A new receptor for beta-glucans","volume":"413","author":"Brown","year":"2001","journal-title":"Nature"},{"key":"2023012312510264200_jlb10482-bib-0010","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4049\/jimmunol.156.3.1235","article-title":"Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b\/CD18)","volume":"156","author":"Thornton","year":"1996","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0011","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20020470","article-title":"Dectin-1 is a major beta-glucan receptor on macrophages","volume":"196","author":"Brown","year":"2002","journal-title":"J Exp Med"},{"key":"2023012312510264200_jlb10482-bib-0012","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.immuni.2005.03.004","article-title":"Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins","volume":"22","author":"Rogers","year":"2005","journal-title":"Immunity"},{"key":"2023012312510264200_jlb10482-bib-0013","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10071","article-title":"Activation of the innate immune receptor Dectin-1 upon formation of a \u2018phagocytic synapse\u2019","volume":"472","author":"Goodridge","year":"2011","journal-title":"Nature"},{"key":"2023012312510264200_jlb10482-bib-0014","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.120.4.1031","article-title":"The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b\/CD18) for four distinct adhesion ligands","volume":"120","author":"Diamond","year":"1993","journal-title":"J Cell Biol"},{"key":"2023012312510264200_jlb10482-bib-0015","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/ni1407","article-title":"Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs","volume":"7","author":"M\u00f3csai","year":"2006","journal-title":"Nat Immunol"},{"key":"2023012312510264200_jlb10482-bib-0016","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.molimm.2009.09.018","article-title":"Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles","volume":"47","author":"van Bruggen","year":"2009","journal-title":"Mol Immunol"},{"key":"2023012312510264200_jlb10482-bib-0017","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.1501811","article-title":"Human neutrophils use different mechanisms to kill Aspergillus fumigatus Conidia and Hyphae: evidence from phagocyte defects","volume":"196","author":"Gazendam","year":"2016","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0018","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1172\/JCI63239","article-title":"Fungal antioxidant pathways promote survival against neutrophils during infection","volume":"122","author":"Leal","year":"2012","journal-title":"J Clin Invest"},{"key":"2023012312510264200_jlb10482-bib-0019","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2019.00123","article-title":"CD11b regulates fungal outgrowth but not neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis","volume":"10","author":"Teschner","year":"2019","journal-title":"Front Immunol"},{"key":"2023012312510264200_jlb10482-bib-0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.mib.2012.06.003","article-title":"Unravelling fungal immunity through primary immune deficiencies","volume":"15","author":"Lilic","year":"2012","journal-title":"Curr Opin Microbiol"},{"key":"2023012312510264200_jlb10482-bib-0021","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/imr.12454","article-title":"How neutrophils kill fungi","volume":"273","author":"Gazendam","year":"2016","journal-title":"Immunol Rev"},{"key":"2023012312510264200_jlb10482-bib-0022","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"key":"2023012312510264200_jlb10482-bib-0023","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"2023012312510264200_jlb10482-bib-0024","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1189\/jlb.1211601","article-title":"Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus","volume":"92","author":"Parker","year":"2012","journal-title":"J Leukoc Biol"},{"key":"2023012312510264200_jlb10482-bib-0025","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/cdd.2009.96","article-title":"Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps","volume":"16","author":"Yousefi","year":"2009","journal-title":"Cell Death Differ"},{"key":"2023012312510264200_jlb10482-bib-0026","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimar\u00e3es-Costa","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023012312510264200_jlb10482-bib-0027","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J Cell Biol"},{"key":"2023012312510264200_jlb10482-bib-0028","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2012.06.011","article-title":"Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis","volume":"12","author":"McDonald","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2023012312510264200_jlb10482-bib-0029","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat Med"},{"key":"2023012312510264200_jlb10482-bib-0030","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jaci.2011.01.021","article-title":"Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent","volume":"127","author":"Bianchi","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"2023012312510264200_jlb10482-bib-0031","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/IAI.00096-14","article-title":"NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis","volume":"82","author":"R\u00f6hm","year":"2014","journal-title":"Infect Immun"},{"key":"2023012312510264200_jlb10482-bib-0032","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/blood-2009-05-221606","article-title":"Restoration of NET formation by gene therapy in CGD controls aspergillosis","volume":"114","author":"Bianchi","year":"2009","journal-title":"Blood"},{"key":"2023012312510264200_jlb10482-bib-0033","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J Exp Med"},{"key":"2023012312510264200_jlb10482-bib-0034","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat Chem Biol"},{"key":"2023012312510264200_jlb10482-bib-0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J Cell Biol"},{"key":"2023012312510264200_jlb10482-bib-0036","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3389\/fimmu.2018.01573","article-title":"Induced NETosis is independent of peptidylarginine deiminase 4","volume":"9","author":"Guiducci","year":"2018","journal-title":"Front Immunol."},{"key":"2023012312510264200_jlb10482-bib-0037","doi-asserted-by":"crossref","first-page":"e24437","DOI":"10.7554\/eLife.24437","article-title":"Diverse stimuli engage different neutrophil extracellular trap pathways","volume":"6","author":"Kenny","year":"2017","journal-title":"Elife"},{"key":"2023012312510264200_jlb10482-bib-0038","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"2023012312510264200_jlb10482-bib-0039","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fimmu.2013.00038","article-title":"Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release","volume":"4","author":"Neeli","year":"2013","journal-title":"Front Immunol"},{"key":"2023012312510264200_jlb10482-bib-0040","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023012312510264200_jlb10482-bib-0041","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.micinf.2010.06.009","article-title":"NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus","volume":"12","author":"McCormick","year":"2010","journal-title":"Microbes Infect"},{"key":"2023012312510264200_jlb10482-bib-0042","doi-asserted-by":"crossref","first-page":"e1000873","DOI":"10.1371\/journal.ppat.1000873","article-title":"Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA","volume":"6","author":"Bruns","year":"2010","journal-title":"PLoS Pathog"},{"key":"2023012312510264200_jlb10482-bib-0043","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3389\/fimmu.2018.01182","article-title":"Protein deiminase 4 and CR3 regulate","volume":"9","author":"Clark","year":"2018","journal-title":"Front Immunol"},{"key":"2023012312510264200_jlb10482-bib-0044","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1074\/jbc.M111.298307","article-title":"Lectin site ligation of CR3 induces conformational changes and signaling","volume":"287","author":"O'Brien","year":"2012","journal-title":"J Biol Chem"},{"key":"2023012312510264200_jlb10482-bib-0045","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.4049\/jimmunol.1002268","article-title":"Class IA phosphoinositide 3-kinase \u03b2 and \u03b4 regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae","volume":"186","author":"Boyle","year":"2011","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0046","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.4049\/jimmunol.170.5.2647","article-title":"Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement","volume":"170","author":"Sadhu","year":"2003","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0047","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.287.5455.1049","article-title":"Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation","volume":"287","author":"Hirsch","year":"2000","journal-title":"Science"},{"key":"2023012312510264200_jlb10482-bib-0048","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.287.5455.1040","article-title":"Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration","volume":"287","author":"Sasaki","year":"2000","journal-title":"Science"},{"key":"2023012312510264200_jlb10482-bib-0049","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1084\/jem.20021787","article-title":"Collaborative induction of inflammatory responses by Dectin-1 and Toll-like receptor 2","volume":"197","author":"Gantner","year":"2003","journal-title":"J Exp Med"},{"key":"2023012312510264200_jlb10482-bib-0050","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1084\/jem.20021890","article-title":"Dectin-1 mediates the biological effects of beta-glucans","volume":"197","author":"Brown","year":"2003","journal-title":"J Exp Med"},{"key":"2023012312510264200_jlb10482-bib-0051","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat Immunol"},{"key":"2023012312510264200_jlb10482-bib-0052","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.4049\/jimmunol.162.12.7285","article-title":"Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b\/CD18)","volume":"162","author":"Xia","year":"1999","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0053","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.120.2.545","article-title":"A subpopulation of Mac-1 (CD11b\/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen","volume":"120","author":"Diamond","year":"1993","journal-title":"J Cell Biol"},{"key":"2023012312510264200_jlb10482-bib-0054","article-title":"Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus","author":"Muniz","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2023012312510264200_jlb10482-bib-0055","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.4049\/jimmunol.1202671","article-title":"An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans","volume":"190","author":"Byrd","year":"2013","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0056","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(02)00303-5","article-title":"Syk is required for integrin signaling in neutrophils","volume":"16","author":"M\u00f3csai","year":"2002","journal-title":"Immunity"},{"key":"2023012312510264200_jlb10482-bib-0057","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1182\/blood-2009-05-220806","article-title":"Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection","volume":"114","author":"Van Ziffle","year":"2009","journal-title":"Blood"},{"key":"2023012312510264200_jlb10482-bib-0058","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000365249","article-title":"Src family kinases and Syk are required for neutrophil extracellular trap formation in response to \u03b2-glucan particles","volume":"7","author":"Nan\u00ec","year":"2015","journal-title":"J Innate Immun"},{"key":"2023012312510264200_jlb10482-bib-0059","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.1400478","article-title":"Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via Fc\u03b3RIIIB and Mac-1","volume":"193","author":"Behnen","year":"2014","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.it.2005.02.002","article-title":"Src and Syk kinases: key regulators of phagocytic cell activation","volume":"26","author":"Berton","year":"2005","journal-title":"Trends Immunol"},{"key":"2023012312510264200_jlb10482-bib-0061","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.162.2.1120","article-title":"Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck","volume":"162","author":"M\u00f3csai","year":"1999","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0062","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.133.4.895","article-title":"Deficiency of Src family kinases p59\/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions","volume":"133","author":"Lowell","year":"1996","journal-title":"J Cell Biol"},{"key":"2023012312510264200_jlb10482-bib-0063","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15252\/embr.201439466","article-title":"Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils","volume":"16","author":"Luo","year":"2015","journal-title":"EMBO Rep"},{"key":"2023012312510264200_jlb10482-bib-0064","doi-asserted-by":"crossref","first-page":"561","DOI":"10.15252\/embj.201593564","article-title":"Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic","volume":"35","author":"Marat","year":"2016","journal-title":"EMBO J"},{"key":"2023012312510264200_jlb10482-bib-0065","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm1284","article-title":"Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis","volume":"11","author":"Camps","year":"2005","journal-title":"Nat Med"},{"key":"2023012312510264200_jlb10482-bib-0066","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fimmu.2012.00307","article-title":"PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures","volume":"3","author":"Leshner","year":"2012","journal-title":"Front Immunol"},{"key":"2023012312510264200_jlb10482-bib-0067","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.4049\/jimmunol.180.3.1895","article-title":"Histone deimination as a response to inflammatory stimuli in neutrophils","volume":"180","author":"Neeli","year":"2008","journal-title":"J Immunol"},{"key":"2023012312510264200_jlb10482-bib-0068","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aal3062","article-title":"Citrullination of NF-\u03baB p65 promotes its nuclear localization and TLR-induced expression of IL-1\u03b2 and TNF\u03b1","volume":"2","author":"Sun","year":"2017","journal-title":"Sci Immunol"},{"key":"2023012312510264200_jlb10482-bib-0069","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1189\/jlb.3A0314-142RR","article-title":"Peptidylarginine deiminase inhibition impairs Toll-like receptor agonist-induced functional maturation of dendritic cells, resulting in the loss of T cell-proliferative capacity: a partial mechanism with therapeutic potential in inflammatory settings","volume":"97","author":"Jang","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2023012312510264200_jlb10482-bib-0070","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1073\/pnas.1301059110","article-title":"Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice","volume":"110","author":"Martinod","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023012312510264200_jlb10482-bib-0071","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.20160530","article-title":"Peptidylarginine deiminase 4 promotes age-related organ fibrosis","volume":"214","author":"Martinod","year":"2017","journal-title":"J Exp Med"},{"key":"2023012312510264200_jlb10482-bib-0072","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1128\/IAI.00909-06","article-title":"Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus Conidia","volume":"74","author":"Bonnett","year":"2006","journal-title":"Infect Immun"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.4A0119-009RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.4A0119-009RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.4A0119-009RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/1\/69\/48795874\/jlb10482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/107\/1\/69\/48795874\/jlb10482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T08:15:30Z","timestamp":1677485730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/107\/1\/69\/6884310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,2]]},"published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.4a0119-009rr","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,9,2]]},"assertion":[{"value":"2019-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}