{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078515,"version":"build-2736575974"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucosal-associated invariant T (MAIT) cells are innate-like, unconventional T cells that are present in peripheral blood and mucosal surfaces. A clear understanding of how MAIT cells in the mucosae function and their role in host immunity is still lacking. Therefore, our aim was to investigate MAIT cell distribution and their characteristics in the gastrointestinal (GI) mucosal tissue based on V\u03b17.2+CD161hi identification. We showed that V\u03b17.2+CD161hi T cells are present in both intraepithelial layer and lamina propriae of the GI mucosa, but have different abundance at each GI site. V\u03b17.2+CD161hi T cells were most abundant in the duodenum, but had the lowest reactivity to MR1-5-OP-RU tetramers when compared with V\u03b17.2+CD161hi T cells at other GI tissue sites. Striking discrepancies between MR1-5-OP-RU tetramer reactive cells and V\u03b17.2+CD161hi T cells were observed along each GI tissue sites. V\u03b17.2+CD161hi TCR repertoire was most diverse in the ileum. Similar dominant profiles of TRBV usage were observed among peripheral blood, duodenum, ileum, and colon. Some TRBV chains were detected at certain intestinal sites and not elsewhere. The frequency of peripheral blood V\u03b17.2+CD161hi T cells correlated with mucosal V\u03b17.2+CD161hi T cells in lamina propriae ileum and lamina propriae colon. The frequency of peripheral blood V\u03b17.2+CD161hi T cells in Helicobacter pylori-infected individuals was significantly lower than uninfected individuals, but this was not observed with gastric V\u03b17.2+CD161hi T cells. This study illustrates the biology of V\u03b17.2+CD161hi T cells in the GI mucosa and provides a basis for understanding MAIT cells in the mucosa and MAIT-related GI diseases.<\/jats:p>","DOI":"10.1002\/jlb.4a0421-223rr","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T13:12:08Z","timestamp":1655298728000},"page":"717-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human mucosal V\u03b17.2+CD161hi T cell distribution at physiologic state and in\n                    <i>Helicobacter pylori<\/i>\n                    infection"],"prefix":"10.1093","volume":"112","author":[{"given":"Norasate","family":"Boonpattanaporn","sequence":"first","affiliation":[{"name":"Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thidarat","family":"Kongkaew","sequence":"additional","affiliation":[{"name":"Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panjana","family":"Sengprasert","sequence":"additional","affiliation":[{"name":"Immunology Division, Faculty of Medicine, Department of Microbiology, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N T","family":"Souter","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity , Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisorn","family":"Lakananurak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medicine, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungsun","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medicine, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J","family":"Corbett","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity , Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangsima","family":"Reantragoon","sequence":"additional","affiliation":[{"name":"Immunology Division, Faculty of Medicine, Department of Microbiology, Chulalongkorn University , Bangkok, Thailand"},{"name":"Faculty of Medicine, Center of Excellence in Immunology and Immune-Mediated Diseases, Chulalongkorn University , Bangkok, Thailand"},{"name":"Faculty of Medicine, Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Chulalongkorn University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"2023032107561553300_","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature01433","article-title":"Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1","volume":"422","author":"Treiner","year":"2003","journal-title":"Nature"},{"key":"2023032107561553300_","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20130958","article-title":"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells","volume":"210","author":"Reantragoon","year":"2013","journal-title":"J Exp 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