{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:06:01Z","timestamp":1792677961376,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut-associated sepsis is a major problem in patients undergoing abdominal radiation therapy; the majority of pathogens causing this type of sepsis are translocated from the gut microbiota. While treating sepsis, bacterial clearance must be achieved to ensure patient survival, and the hepatic immune response is responsible for this process. In particular, Kupffer cells play a crucial role in the hepatic immune response against infectious agents. Recently, two populations of Kupffer cells have been described: liver-resident macrophages (M\u03d5) (F4\/80+CD11b\u2013CD68+ cells) and hepatic M\u03d5 derived from circulating monocytes (F4\/80+CD11b+CD68\u2013 cells). We examined the properties of both types of hepatic M\u03d5 obtained from irradiated and normal mice and their role in sepsis. Hepatic F4\/80+CD11b\u2013CD68+ cells from both normal and irradiated mice did not show any antibacterial activity. However, F4\/80+CD11b+CD68\u2013 cells from normal mice behaved as effector cells against sepsis by Enterococcus faecalis, although those from irradiated mice lost this ability. Moreover, hepatic F4\/80+CD11b+CD68\u2013 cells from normal infected mice were shown to be IL-12+IL-10\u2013CD206\u2013CCL1\u2013 (considered M1M\u03d5), and hepatic F4\/80+CD11b\u2013CD68+ cells from the same mice were shown to be IL-12\u2013IL-10+CD206+CCL1\u2013 (considered M2aM\u03d5). When normal mice were exposed to radiation, hepatic F4\/80+CD11b+CD68\u2013 cells altered their phenotype to IL-12\u2013IL-10+CD206\u2013CCL1+ (considered M2bM\u03d5), independent of infection, but hepatic F4\/80+CD11b\u2013CD68+ cells remained IL-12\u2013IL-10+CD206+CCL1\u2013 (M2aM\u03d5). In addition, hepatic F4\/80+CD11b+CD68\u2013 cells from irradiated mice acquired antibacterial activity upon treatment with CCL1 antisense oligodeoxynucleotides. Therefore, the characteristics of hepatic F4\/80+CD11b+CD68\u2013 cells play a key role in the antibacterial response against gut-associated sepsis.<\/jats:p>","DOI":"10.1002\/jlb.4a0820-550rr","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:49:05Z","timestamp":1619444945000},"page":"943-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hepatic F4\/80+CD11b+CD68\u2013 cells influence the antibacterial response in irradiated mice with sepsis by <i>Enterococcus faecalis<\/i>"],"prefix":"10.1093","volume":"109","author":[{"given":"Norio","family":"Okamoto","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideko","family":"Ohama","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Fukunishi","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Asai","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Osaka Medical College , Takatsuki , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"2023032108264217700_jlb10896-cit-0001","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"2023032108264217700_jlb10896-cit-0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S2468-1253(16)30119-4","article-title":"The role of the gut microbiota in sepsis","volume":"2","author":"Haak","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2023032108264217700_jlb10896-cit-0003","doi-asserted-by":"crossref","first-page":"e013502","DOI":"10.1136\/bmjopen-2016-013502","article-title":"Are patients with cancer with sepsis and bacteraemia at a higher risk of mortality? 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