{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:05:03Z","timestamp":1793808303883,"version":"4.6.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fundaci\u00f3n de Investigaci\u00f3n Biom\u00e9dica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The CD64 receptor has been described as a biomarker of bacterial infection. We speculated that CD64 surface expression on monocytes and granulocytes of children with severe acute bronchiolitis (SAB) could be altered in cases of probable bacterial infection (PBI) determined using classical biomarkers (procalcitonin and C-reactive protein, leukocyte count, and radiographic findings). A prospective observational pilot study was conducted from October 2015 to February 2016 in children admitted for pediatric critical care. A blood sample was taken in the first 24\u00a0hours of admission, and CD64 was measured by flow cytometry. The values obtained were analyzed and correlated with traditional biomarkers of PBI. Thirty-two children were included; a correlation was found between CD64 expression and the PBI criteria. CD64 surface expression was higher in children with PBI (area under the receiver operating characteristic curve of 0.73; P\u00a0=\u00a00.042) and the percentage of CD64+ granulocytes was higher in children with PBI. This is the first study to describe CD64 surface expression on monocytes and granulocytes in SAB, finding CD64 values to be higher in children with PBI. Larger clinical studies are needed to elucidate the real accuracy of CD64 as a biomarker of bacterial infection.<\/jats:p>","DOI":"10.1002\/jlb.4ab0417-152rrr","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T15:34:57Z","timestamp":1519745697000},"page":"965-971","source":"Crossref","is-referenced-by-count":10,"title":["CD64 on monocytes and granulocytes in severe acute bronchiolitis: Pilot study on its usefulness as a bacterial infection biomarker"],"prefix":"10.1093","volume":"103","author":[{"given":"Alberto","family":"Garc\u00eda-Salido","sequence":"first","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Serrano-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Casado-Flores","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Sierra-Colomina","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia Mart\u00ednez","family":"de Azagra-Garde","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Garc\u00eda-Teresa","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo J","family":"Melen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Universidad Aut\u00f3noma de Madrid , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ram\u00edrez-Orellana","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Universidad Aut\u00f3noma de Madrid , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"2023032406055744000_","doi-asserted-by":"crossref","first-page":"e492","DOI":"10.1542\/peds.2012-0444","article-title":"Prospective multicenter study of children with bronchiolitis requiring mechanical 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