{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:55:37Z","timestamp":1779170137642,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":439,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role in regulation of immune cell trafficking and chemokine production. PAD4 regulates liver immunopathology by promoting neutrophil trafficking in a Plasmodium chabaudi mouse malaria model. In human macrophages, PAD4 regulates expression of CXCL chemokines in response to stimulation with TLR ligands and P. falciparum. Using patient samples, we show that CXCL1 may be a biomarker for severe malaria. PAD4 inhibition promotes disease tolerance and may represent a therapeutic avenue in malaria.<\/jats:p>","DOI":"10.1002\/jlb.4ab1120-780r","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T11:32:53Z","timestamp":1636543973000},"page":"1235-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["PAD4 controls chemoattractant production and neutrophil trafficking in malaria"],"prefix":"10.1093","volume":"111","author":[{"given":"Drinalda","family":"Cela","sequence":"first","affiliation":[{"name":"University of Bristol, School of Cellular and Molecular Medicine , Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian Lorenz","family":"Knackstedt","sequence":"additional","affiliation":[{"name":"Department of Cellular Microbiology, Max Planck Institute for Infection Biology , Berlin, 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, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borko","family":"Amulic","sequence":"additional","affiliation":[{"name":"University of Bristol, School of Cellular and Molecular Medicine , Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"2023032108503831200_","doi-asserted-by":"crossref","first-page":"700","DOI":"10.2174\/1389450116666150202160954","article-title":"Protein arginine deiminases and associated citrullination: physiological functions and diseases associated with dysregulation","volume":"16","author":"Witalison","year":"2015","journal-title":"Curr Drug Targets"},{"key":"2023032108503831200_","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/ard.2003.012211","article-title":"Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and 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