{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:19:52Z","timestamp":1777612792341,"version":"3.51.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL108801"],"award-info":[{"award-number":["P01HL108801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI061246"],"award-info":[{"award-number":["U01AI061246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI38318"],"award-info":[{"award-number":["U01AI38318"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM1184566"],"award-info":[{"award-number":["R01GM1184566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL091957"],"award-info":[{"award-number":["R01HL091957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM115605"],"award-info":[{"award-number":["R01GM115605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HD007466"],"award-info":[{"award-number":["T32HD007466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08GM126313"],"award-info":[{"award-number":["K08GM126313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HL108801"],"award-info":[{"award-number":["P01HL108801"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI061246"],"award-info":[{"award-number":["U01AI061246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AI38318"],"award-info":[{"award-number":["U01AI38318"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM1184566"],"award-info":[{"award-number":["R01GM1184566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL091957"],"award-info":[{"award-number":["R01HL091957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM115605"],"award-info":[{"award-number":["R01GM115605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HD007466"],"award-info":[{"award-number":["T32HD007466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08GM126313"],"award-info":[{"award-number":["K08GM126313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High mobility group (HMG) proteins are a family of architectural transcription factors, with HMGA1 playing a role in the regulation of genes involved in promoting systemic inflammatory responses. We speculated that blocking HMGA1-mediated pathways might improve outcomes from sepsis. To investigate HMGA1 further, we developed genetically modified mice expressing a dominant negative (dn) form of HMGA1 targeted to the vasculature. In dnHMGA1 transgenic (Tg) mice, endogenous HMGA1 is present, but its function is decreased due to the mutant transgene. These mice allowed us to specifically study the importance of HMGA1 not only during a purely pro-inflammatory insult of endotoxemia, but also during microbial sepsis induced by implantation of a bacterial-laden fibrin clot into the peritoneum. We found that the dnHMGA1 transgene was only present in Tg and not wild-type (WT) littermate mice, and the mutant transgene was able to interact with transcription factors (such as NF-\u03baB), but was not able to bind DNA. Tg mice exhibited a blunted hypotensive response to endotoxemia, and less mortality in microbial sepsis. Moreover, Tg mice had a reduced inflammatory response during sepsis, with decreased macrophage and neutrophil infiltration into tissues, which was associated with reduced expression of monocyte chemotactic protein-1 and macrophage inflammatory protein-2. Collectively, these data suggest that targeted expression of a dnHMGA1 transgene is able to improve outcomes in models of endotoxin exposure and microbial sepsis, in part by modulating the immune response and suggest a novel modifiable pathway to target therapeutics in sepsis.<\/jats:p>\n               <jats:p>High mobility group A1 is a modifiable pathway for therapeutics in sepsis, using a dominant negative approach to regulate the immune response.<\/jats:p>","DOI":"10.1002\/jlb.4hi0817-333rr","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T17:42:10Z","timestamp":1530812530000},"page":"677-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis"],"prefix":"10.1093","volume":"104","author":[{"given":"Rebecca M","family":"Baron","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P","family":"Castano","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sailaja","family":"Ghanta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario F","family":"Riascos-Bernal","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine , Bronx, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Lopez-Guzman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro Andres","family":"Macias","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonna","family":"Ith","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott L","family":"Schissel","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"Lederer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Washington State University , Pullman, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaw-Fang","family":"Yet","sequence":"additional","affiliation":[{"name":"Institute of Cellular and System Medicine, National Health Research Institutes , Zhunan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D","family":"Layne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Boston University School of Medicine , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Perrella","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"},{"name":"Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"2023032406114090500_jlb10193-cit-0001","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.gde.2005.08.007","article-title":"HMG proteins: dynamic players in gene regulation and differentiation","volume":"15","author":"Bianchi","year":"2005","journal-title":"Curr Opin Genet Dev"},{"key":"2023032406114090500_jlb10193-cit-0002","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0167-4781(01)00215-9","article-title":"HMGI\/Y proteins: flexible regulators of transcription and chromatin structure","volume":"1519","author":"Reeves","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"2023032406114090500_jlb10193-cit-0003","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1093\/nar\/17.15.5947","article-title":"Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif","volume":"17","author":"Eckner","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"2023032406114090500_jlb10193-cit-0004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-4827(90)90118-T","article-title":"Expression of mRNAs encoding mammalian chromosomal proteins HMG-I and HMG-Y during cellular proliferation","volume":"187","author":"Johnson","year":"1990","journal-title":"Exp Cell Res"},{"key":"2023032406114090500_jlb10193-cit-0005","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1021\/bi952424p","article-title":"Substrate structure influences binding of the non-histone protein HMG-I(Y) to free nucleosomal DNA","volume":"35","author":"Reeves","year":"1996","journal-title":"Biochemistry"},{"key":"2023032406114090500_jlb10193-cit-0006","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(92)90129-Z","article-title":"The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures","volume":"69","author":"Giese","year":"1992","journal-title":"Cell"},{"key":"2023032406114090500_jlb10193-cit-0007","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0092-8674(95)90137-X","article-title":"Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y)","volume":"83","author":"Falvo","year":"1995","journal-title":"Cell"},{"key":"2023032406114090500_jlb10193-cit-0008","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(92)90554-P","article-title":"The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene","volume":"71","author":"Thanos","year":"1992","journal-title":"Cell"},{"key":"2023032406114090500_jlb10193-cit-0009","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(93)90468-6","article-title":"Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements","volume":"74","author":"Du","year":"1993","journal-title":"Cell"},{"key":"2023032406114090500_jlb10193-cit-0010","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0092-8674(95)90136-1","article-title":"Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome","volume":"83","author":"Thanos","year":"1995","journal-title":"Cell"},{"key":"2023032406114090500_jlb10193-cit-0011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0079-6603(08)60360-8","article-title":"High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function","volume":"54","author":"Bustin","year":"1996","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"2023032406114090500_jlb10193-cit-0012","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1074\/jbc.274.3.1525","article-title":"Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1b in vascular smooth muscle cells: role in activation of inducible nitric oxide synthase","volume":"274","author":"Pellacani","year":"1999","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0013","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1074\/jbc.M008170200","article-title":"Downregulation of high mobility group-I(Y) protein contributes to the inhibition of nitric oxide synthase 2 by transforming growth factor-b1","volume":"276","author":"Pellacani","year":"2001","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0014","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1074\/jbc.274.13.9045","article-title":"High mobility group-I(Y) protein facilitates nuclear factor-kappaB binding and transactivation of the inducible nitric-oxide synthase promoter\/enhancer","volume":"274","author":"Perrella","year":"1999","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0015","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1210\/en.2003-1200","article-title":"An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells","volume":"145","author":"Darville","year":"2004","journal-title":"Endocrinology"},{"key":"2023032406114090500_jlb10193-cit-0016","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.febslet.2008.02.008","article-title":"High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression","volume":"582","author":"Takamiya","year":"2008","journal-title":"FEBS Lett"},{"key":"2023032406114090500_jlb10193-cit-0017","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1097\/00003246-200201001-00005","article-title":"High Mobility Group-I\/Y Proteins: potential role in the pathophysiology of critical illnesses","volume":"30","author":"Carvajal","year":"2002","journal-title":"Crit Care Med"},{"key":"2023032406114090500_jlb10193-cit-0018","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1158\/0008-5472.CAN-09-1212","article-title":"The high mobility group A1 gene: transforming inflammatory signals into cancer?","volume":"70","author":"Resar","year":"2010","journal-title":"Cancer Res"},{"key":"2023032406114090500_jlb10193-cit-0019","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1186\/1471-2164-12-549","article-title":"HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis","volume":"12","author":"Schuldenfrei","year":"2011","journal-title":"BMC Genomics"},{"key":"2023032406114090500_jlb10193-cit-0020","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.4049\/jimmunol.173.6.4147","article-title":"Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia","volume":"173","author":"Baron","year":"2004","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0021","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1042\/BJ20081427","article-title":"Netropsin improves survival from endotoxemia by disrupting HMGA1-binding to the NOS2 promoter","volume":"418","author":"Grant","year":"2009","journal-title":"Biochem J"},{"key":"2023032406114090500_jlb10193-cit-0022","doi-asserted-by":"crossref","first-page":"e10656","DOI":"10.1371\/journal.pone.0010656","article-title":"Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia","volume":"5","author":"Baron","year":"2010","journal-title":"PLoS One"},{"key":"2023032406114090500_jlb10193-cit-0023","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/0008-5472.CAN-05-1889","article-title":"Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice","volume":"66","author":"Fedele","year":"2006","journal-title":"Cancer Res"},{"key":"2023032406114090500_jlb10193-cit-0024","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/bbrc.2002.6672","article-title":"Dominant-negative HMGA1 blocks \u03bc enhancer activation through a novel mechanism","volume":"292","author":"Andreucci","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2023032406114090500_jlb10193-cit-0025","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.4049\/jimmunol.164.6.3157","article-title":"The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation","volume":"164","author":"Himes","year":"2000","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0026","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MCB.21.2.575-594.2001","article-title":"Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells","volume":"21","author":"Reeves","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2023032406114090500_jlb10193-cit-0027","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/01.RES.0000013289.97650.C8","article-title":"Characterization of the mouse aortic carboxypeptidase-like protein promoter reveals activity in differentiated and dedifferentiated vascular smooth muscle cells","volume":"90","author":"Layne","year":"2002","journal-title":"Circ Res"},{"key":"2023032406114090500_jlb10193-cit-0028","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1172\/JCI32730","article-title":"Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice","volume":"118","author":"Chung","year":"2008","journal-title":"J Clin Invest"},{"key":"2023032406114090500_jlb10193-cit-0029","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1172\/JCI6163","article-title":"Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice","volume":"103","author":"Yet","year":"1999","journal-title":"J Clin Invest"},{"key":"2023032406114090500_jlb10193-cit-0030","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1161\/ATVBAHA.111.235135","article-title":"Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury","volume":"31","author":"Kwon","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023032406114090500_jlb10193-cit-0031","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1189\/jlb.4A0214-087R","article-title":"Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages","volume":"97","author":"Tsoyi","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2023032406114090500_jlb10193-cit-0032","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1074\/jbc.M409125200","article-title":"Role of Ets-2 in the regulation of heme oxygenase-1 by endotoxin","volume":"280","author":"Chung","year":"2005","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0033","doi-asserted-by":"crossref","first-page":"13776","DOI":"10.1074\/jbc.271.23.13776","article-title":"Suppression of interleukin-1\u03b2-induced nitric-oxide synthase promoter\/enhancer activity by transforming growth factor-\u03b21 in vascular smooth muscle cells. Evidence for mechanisms other than NF-\u03baB","volume":"271","author":"Perrella","year":"1996","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0034","doi-asserted-by":"crossref","first-page":"39572","DOI":"10.1074\/jbc.M308179200","article-title":"Elk-3 is a transcriptional repressor of nitric-oxide synthase 2","volume":"278","author":"Chen","year":"2003","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0035","doi-asserted-by":"crossref","first-page":"L870","DOI":"10.1152\/ajplung.00382.2009","article-title":"Regulation of heme oxygenase-1 gene by peptidoglycan involves the interaction of Elk-1 and C\/EBPalpha to increase expression","volume":"298","author":"Hung","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2023032406114090500_jlb10193-cit-0036","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1161\/01.HYP.29.4.1025","article-title":"Two-kidney, one clip and one-kidney, one clip hypertension in mice","volume":"29","author":"Wiesel","year":"1997","journal-title":"Hypertension"},{"key":"2023032406114090500_jlb10193-cit-0037","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1073\/pnas.93.5.2054","article-title":"Arrest of endotoxin-induced hypotension by transforming growth factor \u00df1","volume":"93","author":"Perrella","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406114090500_jlb10193-cit-0038","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/ajrccm.163.1.9909034","article-title":"Septic shock and acute lung injury in rabbits with peritonitis","volume":"163","author":"Matute-Bello","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"2023032406114090500_jlb10193-cit-0039","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/stem.1270","article-title":"Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils","volume":"31","author":"Hall","year":"2012","journal-title":"Stem Cells"},{"key":"2023032406114090500_jlb10193-cit-0040","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.4049\/jimmunol.1101186","article-title":"Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis","volume":"187","author":"Fredenburgh","year":"2011","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0041","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1667\/RR3120.1","article-title":"Immune system phenotyping of radiation and radiation combined injury in outbred mice","volume":"179","author":"Tajima","year":"2013","journal-title":"Radiat Res"},{"key":"2023032406114090500_jlb10193-cit-0042","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4049\/jimmunol.1500597","article-title":"Beneficial effects of CpG-oligodeoxynucleotide treatment on trauma and secondary lung infection","volume":"196","author":"Wanke-Jellinek","year":"2016","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0043","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1128\/IAI.01213-09","article-title":"Characterization and modulation of the immunosuppressive phase of sepsis","volume":"78","author":"Muenzer","year":"2010","journal-title":"Infect Immun"},{"key":"2023032406114090500_jlb10193-cit-0044","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4049\/jimmunol.171.2.909","article-title":"Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells","volume":"171","author":"Tinsley","year":"2003","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138945006775270169","article-title":"Bacterial sepsis and chemokines","volume":"7","author":"Kobayashi","year":"2006","journal-title":"Curr Drug Targets"},{"key":"2023032406114090500_jlb10193-cit-0046","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nature reviews Immunology"},{"key":"2023032406114090500_jlb10193-cit-0047","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/01902149409031733","article-title":"Macrophage inflammatory proteins: biology and role in pulmonary inflammation","volume":"20","author":"Driscoll","year":"1994","journal-title":"Exp Lung Res"},{"key":"2023032406114090500_jlb10193-cit-0048","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"2023032406114090500_jlb10193-cit-0049","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"key":"2023032406114090500_jlb10193-cit-0050","doi-asserted-by":"crossref","first-page":"187048","DOI":"10.1155\/2015\/187048","article-title":"Balancing innate immunity and inflammatory state via modulation of neutrophil function: a novel strategy to fight sepsis","volume":"2015","author":"Fang","year":"2015","journal-title":"J Immunol Res"},{"key":"2023032406114090500_jlb10193-cit-0051","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.8178167","article-title":"Architectural transcription factors","volume":"264","author":"Wolffe","year":"1994","journal-title":"Science"},{"key":"2023032406114090500_jlb10193-cit-0052","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nrc2271","article-title":"Roles of HMGA proteins in cancer","volume":"7","author":"Fusco","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"2023032406114090500_jlb10193-cit-0053","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"2023032406114090500_jlb10193-cit-0054","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.shk.0000228801.56223.92","article-title":"Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1\/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production","volume":"26","author":"Gomes","year":"2006","journal-title":"Shock"},{"key":"2023032406114090500_jlb10193-cit-0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/SHK.0b013e31827802b5","article-title":"Bacterial clearance in septic mice is modulated by MCP-1\/CCL2 and nitric oxide","volume":"39","author":"Gomes","year":"2013","journal-title":"Shock"},{"key":"2023032406114090500_jlb10193-cit-0056","doi-asserted-by":"crossref","first-page":"31092","DOI":"10.1074\/jbc.272.49.31092","article-title":"Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappaB sites and NF-kappaB\/Rel subunit specificity","volume":"272","author":"Ueda","year":"1997","journal-title":"J Biol Chem"},{"key":"2023032406114090500_jlb10193-cit-0057","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1046\/j.1523-1755.2000.00051.x","article-title":"Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent","volume":"57","author":"Wang","year":"2000","journal-title":"Kidney Int"},{"key":"2023032406114090500_jlb10193-cit-0058","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.4049\/jimmunol.150.11.4996","article-title":"Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines","volume":"150","author":"Widmer","year":"1993","journal-title":"J Immunol"},{"key":"2023032406114090500_jlb10193-cit-0059","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1128\/IAI.00067-11","article-title":"Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection","volume":"79","author":"Balamayooran","year":"2011","journal-title":"Infect Immun"},{"key":"2023032406114090500_jlb10193-cit-0060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1615\/CritRevImmunol.v26.i4.20","article-title":"Neutrophil infiltration and chemokines","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"2023032406114090500_jlb10193-cit-0061","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.2741\/2853","article-title":"The role of chemokines in neutrophil biology","volume":"13","author":"Kobayashi","year":"2008","journal-title":"Front Biosci"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.4HI0817-333RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.4HI0817-333RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.4HI0817-333RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/104\/4\/677\/49557845\/jlb10193.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/104\/4\/677\/49557845\/jlb10193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:16:58Z","timestamp":1679638618000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/104\/4\/677\/6935409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":61,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,5]]},"published-print":{"date-parts":[[2018,9,28]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.4hi0817-333rr","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2018,10]]},"published":{"date-parts":[[2018,7,5]]}}}