{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:47:06Z","timestamp":1793278026962,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Given the increasing incidence of pulmonary aspergillosis, it is important to understand the natural defense mechanisms by which the body can kill Aspergillus fumigatus conidia. Pentraxin 3 (PTX3) plays a nonredundant role in resistance to A. fumigatus. Here, we found that the key predicted PTX3 transcription factor, CCAAT\/enhancer-binding protein \u03b4 (CEBPD), was up-regulated during A. fumigatus conidia infection. Functionally, CEBPD significantly promoted the expression of PTX3 and the phagocytic ability of macrophages. Mechanistically, CEBPD activated the PTX3 by directly binding to the promoter region of the PTX3 gene. We also showed that the RNA-binding protein human antigen R promoted CEBPD expression. These findings provide new insights into the crucial role of CEBPD in the phagocytosis of A. fumigatus conidia by macrophages and highlight this protein as a potential therapeutic target for invasive pulmonary aspergillosis.<\/jats:p>","DOI":"10.1002\/jlb.4ma1121-451rr","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T20:41:12Z","timestamp":1640292072000},"page":"1225-1234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CCAAT\/enhancer binding protein (C\/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during<i>A. fumigatus<\/i>infection"],"prefix":"10.1093","volume":"111","author":[{"given":"Lulu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University , Nanjing, China"},{"name":"Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University , Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University , Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University , Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Jinling Hospital , Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Jinling Hospital , Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University , Nanjing, China"},{"name":"Department of Clinical Laboratory, Jinling Hospital , Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"2023032108505748600_","first-page":"86","article-title":"A multicentre retrospective study of pulmonary mycosis clinically proven from 1998 to 2007","volume":"34","author":"Liu","year":"2011","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"2023032108505748600_","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09059180.00001011","article-title":"Pulmonary aspergillosis\u202f: a clinical review [J]","volume":"20","author":"Kousha","year":"2011","journal-title":"Eur Respir 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[J]","volume":"6","author":"Chi","year":"2015","journal-title":"Oncotarget"},{"key":"2023032108505748600_","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1158\/0008-5472.CAN-04-3765","article-title":"Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma [J]","volume":"65","author":"Heinonen","year":"2005","journal-title":"Cancer Res"},{"key":"2023032108505748600_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4143\/crt.2009.41.2.87","article-title":"Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer [J]","volume":"41","author":"Lim","year":"2009","journal-title":"Cancer Res Treat"},{"key":"2023032108505748600_","doi-asserted-by":"crossref","first-page":"4020937","DOI":"10.1155\/2018\/4020937","article-title":"Clinical significance and biological role of HuR in head and neck carcinomas [J]","volume":"2018","author":"Levidou","year":"2018","journal-title":"Dis 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