{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:05:35Z","timestamp":1790402735387,"version":"4.1.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the past few years, our understanding of immunological memory has evolved remarkably due to a growing body of new knowledge in innate immune memory and immunity. Immunological memory now encompasses both innate and adaptive immune memory. The hypo-reactive and hyper-reactive types of innate immune memory lead to a suppressed and enhanced innate immune protective outcome, respectively. The latter is also named trained innate immunity (TII). The emerging information on innate immune memory has not only shed new light on the mechanisms of host defense but is also revolutionizing our long-held view of vaccination and vaccine strategies. Our current review will examine recent progress and knowledge gaps in innate immune memory with a focus on tissue-resident M\u03d5s, particularly lung M\u03d5s, and their relationship to local antimicrobial innate immunity. We will also discuss the impact of innate immune memory and TII on our understanding of vaccine concept and strategies and the significance of respiratory mucosal route of vaccination against respiratory pathogens.<\/jats:p>","DOI":"10.1002\/jlb.4mr0220-446r","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T12:10:26Z","timestamp":1583237426000},"page":"825-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-0663","authenticated-orcid":true,"given":"Zhou","family":"Xing","sequence":"first","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Afkhami","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jegarubee","family":"Bavananthasivam","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik K","family":"Fritz","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Vaseghi-Shanjani","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Yao","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangalakumari","family":"Jeyanathan","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre , Hamilton, Ontario , Canada"},{"name":"M. G. DeGroote Institute for Infectious Disease Research , Hamilton, Ontario , Canada"},{"name":"Department of Pathology & Molecular Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"2023032108070666300_jlb10582-cit-0001","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nri.2016.13","article-title":"Immunological memory: lessons from the past and a look to the future","volume":"16","author":"Farber","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2023032108070666300_jlb10582-cit-0002","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.smim.2014.09.006","article-title":"BCG-induced protection: effects on innate immune memory","volume":"26","author":"Netea","year":"2014","journal-title":"Semin Immunol"},{"key":"2023032108070666300_jlb10582-cit-0003","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.3389\/fimmu.2018.02869","article-title":"Non-specific effects of vaccines illustrated through the BCG example: from observations to demonstrations","volume":"9","author":"Uthayakumar","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0004","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.aaa3662","article-title":"Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality","volume":"348","author":"Mina","year":"2015","journal-title":"Science"},{"key":"2023032108070666300_jlb10582-cit-0005","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.vaccine.2004.02.054","article-title":"Childhood mortality after oral polio immunisation campaign in Guinea-Bissau","volume":"23","author":"Aaby","year":"2005","journal-title":"Vaccine"},{"key":"2023032108070666300_jlb10582-cit-0006","doi-asserted-by":"crossref","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"2023032108070666300_jlb10582-cit-0007","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/imr.12647","article-title":"Innate immune memory: an evolutionary perspective","volume":"283","author":"Gourbal","year":"2018","journal-title":"Immunol Rev"},{"key":"2023032108070666300_jlb10582-cit-0008","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/JLB.MR0318-104R","article-title":"Long-term reprogramming of the innate immune system","volume":"105","author":"Dominguez-Andres","year":"2019","journal-title":"J Leukoc Biol"},{"key":"2023032108070666300_jlb10582-cit-0009","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2018.09.003","article-title":"The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell Metab"},{"key":"2023032108070666300_jlb10582-cit-0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0011","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0012","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.cell.2018.11.007","article-title":"Trained Immunity and local innate immune memory in the lung","volume":"175","author":"Netea","year":"2018","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0013","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.cell.2018.09.042","article-title":"Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity","volume":"175","author":"Yao","year":"2018","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0014","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.cell.2016.04.049","article-title":"Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response","volume":"165","author":"Weavers","year":"2016","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0015","doi-asserted-by":"crossref","first-page":"e1007358","DOI":"10.1371\/journal.ppat.1007358","article-title":"IFN-\u03b3 immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans","volume":"14","author":"Leopold Wager","year":"2018","journal-title":"PLoS Pathog"},{"key":"2023032108070666300_jlb10582-cit-0016","doi-asserted-by":"crossref","first-page":"E11111","DOI":"10.1073\/pnas.1808353115","article-title":"Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory","volume":"115","author":"Chan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108070666300_jlb10582-cit-0017","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","article-title":"Innate immune memory in the brain shapes neurological disease hallmarks","volume":"556","author":"Wendeln","year":"2018","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0018","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.3389\/fimmu.2018.02943","article-title":"Innate immune cell suppression and the link with secondary lung bacterial pneumonia","volume":"9","author":"Morgan","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0019","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature24271","article-title":"Inflammatory memory sensitizes skin epithelial stem cells to tissue damage","volume":"550","author":"Naik","year":"2017","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0020","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0021","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41385-019-0229-2","article-title":"Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia","volume":"13","author":"Shenoy","year":"2020","journal-title":"Mucosal Immunol"},{"key":"2023032108070666300_jlb10582-cit-0022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.smim.2016.05.003","article-title":"Innate immune memory in mammals","volume":"28","author":"Hamon","year":"2016","journal-title":"Semin Immunol"},{"key":"2023032108070666300_jlb10582-cit-0023","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ni.3857","article-title":"A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes","volume":"18","author":"Machiels","year":"2017","journal-title":"Nat Immunol"},{"key":"2023032108070666300_jlb10582-cit-0024","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/IAI.00298-15","article-title":"Influenza and bacterial superinfection: illuminating the immunologic mechanisms of disease","volume":"83","author":"Rynda-Apple","year":"2015","journal-title":"Infect Immun"},{"key":"2023032108070666300_jlb10582-cit-0025","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1084\/jem.20070891","article-title":"Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection","volume":"205","author":"Didierlaurent","year":"2008","journal-title":"J Exp Med"},{"key":"2023032108070666300_jlb10582-cit-0026","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clim.2012.05.005","article-title":"Immunopathology in influenza virus infection: uncoupling the friend from foe","volume":"144","author":"Damjanovic","year":"2012","journal-title":"Clin Immunol"},{"key":"2023032108070666300_jlb10582-cit-0027","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ajpath.2013.05.016","article-title":"Marked improvement of severe lung immunopathology by influenza-associated pneumococcal superinfection requires the control of both bacterial replication and host immune responses","volume":"183","author":"Damjanovic","year":"2013","journal-title":"Am J Pathol"},{"key":"2023032108070666300_jlb10582-cit-0028","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.4049\/jimmunol.0902772","article-title":"Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung","volume":"184","author":"Small","year":"2010","journal-title":"J Immunol"},{"key":"2023032108070666300_jlb10582-cit-0029","doi-asserted-by":"crossref","first-page":"e1004053","DOI":"10.1371\/journal.ppat.1004053","article-title":"Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection","volume":"10","author":"Schneider","year":"2014","journal-title":"PLoS Pathog"},{"key":"2023032108070666300_jlb10582-cit-0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4049\/jimmunol.1701406","article-title":"Effects of Influenza on alveolar macrophage viability are dependent on mouse genetic strain","volume":"201","author":"Califano","year":"2018","journal-title":"J Immunol"},{"key":"2023032108070666300_jlb10582-cit-0031","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm1765","article-title":"Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection","volume":"14","author":"Sun","year":"2008","journal-title":"Nat Med"},{"key":"2023032108070666300_jlb10582-cit-0032","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1172\/JCI57762","article-title":"Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice","volume":"121","author":"Nakamura","year":"2011","journal-title":"J Clin Invest"},{"key":"2023032108070666300_jlb10582-cit-0033","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1172\/JCI35412","article-title":"Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice","volume":"119","author":"Shahangian","year":"2009","journal-title":"J Clin Invest"},{"key":"2023032108070666300_jlb10582-cit-0034","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.3389\/fimmu.2018.02151","article-title":"STAT2 signaling regulates macrophage phenotype during influenza and bacterial super-infection","volume":"9","author":"Gopal","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0035","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/498911","article-title":"Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia","volume":"193","author":"van der Sluijs","year":"2006","journal-title":"J Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0036","doi-asserted-by":"crossref","first-page":"e1005338","DOI":"10.1371\/journal.ppat.1005338","article-title":"Type I interferon induced epigenetic regulation of macrophages suppresses innate and adaptive immunity in acute respiratory viral infection","volume":"11","author":"Kroetz","year":"2015","journal-title":"PLoS Pathog"},{"key":"2023032108070666300_jlb10582-cit-0037","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ni.3046","article-title":"The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection","volume":"16","author":"Schliehe","year":"2015","journal-title":"Nat Immunol"},{"key":"2023032108070666300_jlb10582-cit-0038","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/infdis\/jiu804","article-title":"Live attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear","volume":"212","author":"Mina","year":"2015","journal-title":"J Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0039","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.cell.2016.09.034","article-title":"\u03b2-Glucan Reverses the epigenetic state of LPS-induced immunological tolerance","volume":"167","author":"Novakovic","year":"2016","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0040","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/mi.2013.14","article-title":"Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections","volume":"6","author":"Guilliams","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2023032108070666300_jlb10582-cit-0041","doi-asserted-by":"crossref","first-page":"eaaw6693","DOI":"10.1126\/sciimmunol.aaw6693","article-title":"Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo","volume":"4","author":"Rothchild","year":"2019","journal-title":"Sci Immunol"},{"key":"2023032108070666300_jlb10582-cit-0042","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20172020","article-title":"Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny","volume":"215","author":"Huang","year":"2018","journal-title":"J Exp Med"},{"key":"2023032108070666300_jlb10582-cit-0043","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2018.08.001","article-title":"Alveolar macrophages provide an early Mycobacterium tuberculosis niche and initiate dissemination","volume":"24","author":"Cohen","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2023032108070666300_jlb10582-cit-0044","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12799","article-title":"Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids","volume":"505","author":"Cambier","year":"2014","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/imr.12268","article-title":"Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis","volume":"264","author":"Hmama","year":"2015","journal-title":"Immunol Rev"},{"key":"2023032108070666300_jlb10582-cit-0046","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3389\/fimmu.2018.02976","article-title":"Beyond killing Mycobacterium tuberculosis: disease tolerance","volume":"9","author":"Divangahi","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0047","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/eji.201344300","article-title":"Restoration of innate immune activation accelerates Th1-cell priming and protection following pulmonary mycobacterial infection","volume":"44","author":"Lai","year":"2014","journal-title":"Eur J Immunol"},{"key":"2023032108070666300_jlb10582-cit-0048","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4049\/jimmunol.1701109","article-title":"CD11b+ dendritic cell-mediated anti-Mycobacterium tuberculosis Th1 activation is counterregulated by CD103+ dendritic cells via IL-10","volume":"200","author":"Lai","year":"2018","journal-title":"J Immunol"},{"key":"2023032108070666300_jlb10582-cit-0049","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/mi.2011.10","article-title":"Initiation and regulation of T-cell responses in tuberculosis","volume":"4","author":"Urdahl","year":"2011","journal-title":"Mucosal Immunol"},{"key":"2023032108070666300_jlb10582-cit-0050","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/imcb.12273","article-title":"The microbiome and immune memory formation","volume":"97","author":"McCoy","year":"2019","journal-title":"Immunol Cell Biol"},{"key":"2023032108070666300_jlb10582-cit-0051","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature05762","article-title":"Herpesvirus latency confers symbiotic protection from bacterial infection","volume":"447","author":"Barton","year":"2007","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0052","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tube.2016.03.003","article-title":"Unraveling methylation changes of host macrophages in Mycobacterium tuberculosis infection","volume":"98","author":"Zheng","year":"2016","journal-title":"Tuberculosis"},{"key":"2023032108070666300_jlb10582-cit-0053","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1038\/ncomms9922","article-title":"Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3","volume":"6","author":"Yaseen","year":"2015","journal-title":"Nat Commun"},{"key":"2023032108070666300_jlb10582-cit-0054","doi-asserted-by":"crossref","first-page":"pii: e39169","DOI":"10.7554\/eLife.39169","article-title":"Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages","volume":"7","author":"Cumming","year":"2018","journal-title":"Elife"},{"key":"2023032108070666300_jlb10582-cit-0055","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.cmi.2019.02.015","article-title":"Trained innate immunity and resistance to Mycobacterium tuberculosis infection","volume":"25","author":"Koeken","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2023032108070666300_jlb10582-cit-0056","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.it.2018.01.006","article-title":"New tuberculosis vaccine strategies: taking aim at un-natural immunity","volume":"39","author":"Jeyanathan","year":"2018","journal-title":"Trends Immunol"},{"key":"2023032108070666300_jlb10582-cit-0057","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1172\/JCI128877","article-title":"Targeting innate immunity for tuberculosis vaccination","volume":"129","author":"Khader","year":"2019","journal-title":"J Clin Invest"},{"key":"2023032108070666300_jlb10582-cit-0058","doi-asserted-by":"crossref","first-page":"pii:jiz147","DOI":"10.1093\/infdis\/jiz147","article-title":"Early clearance of Mycobacterium tuberculosis is associated with increased innate immune responses","author":"Verrall","year":"2019","journal-title":"J Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0059","doi-asserted-by":"crossref","first-page":"pii:jiz168","DOI":"10.1093\/infdis\/jiz168","article-title":"Early clearance of Mycobacterium tuberculosis: the INFECT case contact cohort study in Indonesia","author":"Verrall","year":"2019","journal-title":"J Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"2023032108070666300_jlb10582-cit-0061","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"key":"2023032108070666300_jlb10582-cit-0062","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"2023032108070666300_jlb10582-cit-0063","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","article-title":"Innate and adaptive immune memory: an evolutionary continuum in the host\u2019s response to pathogens","volume":"25","author":"Netea","year":"2019","journal-title":"Cell Host Microbe"},{"key":"2023032108070666300_jlb10582-cit-0064","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/ni.2984","article-title":"Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion","volume":"15","author":"Chen","year":"2014","journal-title":"Nat Immunol"},{"key":"2023032108070666300_jlb10582-cit-0065","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3389\/fimmu.2017.01134","article-title":"What have we learnt about BCG vaccination in the last 20\u2009years","volume":"8","author":"Dockrell","year":"2017","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0066","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/infdis\/jis941","article-title":"Longitudinal changes in CD4+ T-cell memory responses induced by BCG vaccination of newborns","volume":"207","author":"Soares","year":"2013","journal-title":"J Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0067","doi-asserted-by":"crossref","first-page":"628293","DOI":"10.1155\/2012\/628293","article-title":"Understanding delayed T-cell priming, lung recruitment, and airway luminal T-cell responses in host defense against pulmonary tuberculosis","volume":"2012","author":"Shaler","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"2023032108070666300_jlb10582-cit-0068","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/mi.2012.19","article-title":"Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: a critical role of airway luminal T cells","volume":"5","author":"Horvath","year":"2012","journal-title":"Mucosal Immunol"},{"key":"2023032108070666300_jlb10582-cit-0069","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Gu\u00e9rin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032108070666300_jlb10582-cit-0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clim.2014.10.005","article-title":"BCG-induced trained immunity in NK cells: role for non-specific protection to infection","volume":"155","author":"Kleinnijenhuis","year":"2014","journal-title":"Clin Immunol"},{"key":"2023032108070666300_jlb10582-cit-0071","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic pathways in BCG-induced trained immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep"},{"key":"2023032108070666300_jlb10582-cit-0072","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.cmet.2016.10.008","article-title":"Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity","volume":"24","author":"Arts","year":"2016","journal-title":"Cell Metab"},{"key":"2023032108070666300_jlb10582-cit-0073","doi-asserted-by":"crossref","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR\/HIF1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Kumar","year":"2014","journal-title":"Science"},{"key":"2023032108070666300_jlb10582-cit-0074","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41467-019-08659-3","article-title":"Outcomes of controlled human malaria infection after BCG vaccination","volume":"10","author":"Walk","year":"2019","journal-title":"Nat Commun"},{"key":"2023032108070666300_jlb10582-cit-0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2023032108070666300_jlb10582-cit-0076","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.micinf.2009.08.005","article-title":"Use of non-invasive bioluminescent imaging to assess mycobacterial dissemination in mice, treatment with bactericidal drugs and protective immunity","volume":"11","author":"Heuts","year":"2009","journal-title":"Microbes Infect"},{"key":"2023032108070666300_jlb10582-cit-0077","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1016\/j.vaccine.2018.07.035","article-title":"Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4 + T cell population following BCG immunisation","volume":"36","author":"Bull","year":"2018","journal-title":"Vaccine"},{"key":"2023032108070666300_jlb10582-cit-0078","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cell.2017.08.024","article-title":"Organism-level analysis of vaccination reveals networks of protection across tissues","volume":"171","author":"Kadoki","year":"2017","journal-title":"Cell"},{"key":"2023032108070666300_jlb10582-cit-0079","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2019.10.010","article-title":"Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenge","volume":"51","author":"Hoyer","year":"2019","journal-title":"Immunity"},{"key":"2023032108070666300_jlb10582-cit-0080","doi-asserted-by":"crossref","first-page":"e11319","DOI":"10.1371\/journal.pone.0011319","article-title":"Mycobacterium bovis-BCG vaccination induces specific pulmonary transcriptome biosignatures in mice","volume":"5","author":"Aranday Cortes","year":"2010","journal-title":"PLoS One"},{"key":"2023032108070666300_jlb10582-cit-0081","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1128\/IAI.70.10.5471-5478.2002","article-title":"Mycobacterium bovis BCG vaccination augments interleukin-8 mRNA expression and protein production in guinea pig alveolar macrophages infected with Mycobacterium tuberculosis","volume":"70","author":"Lyons","year":"2002","journal-title":"Infect Immun"},{"key":"2023032108070666300_jlb10582-cit-0082","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2249.2007.03425.x","article-title":"Lung macrophages from bacille Calmette-Gu\u00e9rin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth of M. tuberculosis after recombinant guinea pig interferon-\u03b3 activation","volume":"149","author":"Jeevan","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2023032108070666300_jlb10582-cit-0083","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10096-018-03449-z","article-title":"Opposite effects of vaccinia and modified vaccinia Ankara on trained immunity","volume":"38","author":"Blok","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2023032108070666300_jlb10582-cit-0084","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.3389\/fimmu.2018.02936","article-title":"Trained immunity-based vaccines: a new paradigm for the development of broad-spectrum anti-infectious formulations","volume":"9","author":"S\u00e1nchez-Ram\u00f3n","year":"2018","journal-title":"Front Immunol"},{"key":"2023032108070666300_jlb10582-cit-0085","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.celrep.2019.08.004","article-title":"\u03b2-Glucan-induced trained immunity protects against Leishmania braziliensis infection: a crucial role for IL-32","volume":"28","author":"Dos Santos","year":"2019","journal-title":"Cell Rep"},{"key":"2023032108070666300_jlb10582-cit-0086","doi-asserted-by":"crossref","first-page":"16030","DOI":"10.1038\/mtm.2016.30","article-title":"Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens","volume":"3","author":"Afkhami","year":"2016","journal-title":"Mol Ther Methods Clin Dev"},{"key":"2023032108070666300_jlb10582-cit-0087","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/mi.2012.103","article-title":"Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity","volume":"6","author":"Jeyanathan","year":"2013","journal-title":"Mucosal Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.4MR0220-446R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.4MR0220-446R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.4MR0220-446R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/108\/3\/825\/49458747\/jlb10582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/108\/3\/825\/49458747\/jlb10582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T19:44:28Z","timestamp":1679427868000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/108\/3\/825\/6884374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":87,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,3]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.4mr0220-446r","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,3,3]]},"assertion":[{"value":"2019-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}