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Influenza pathogenesis has 2 crucial clinical components; first, influenza causes acute lung injury that may require hospitalization. Second, acute injury promotes secondary bacterial pneumonia, a leading cause of hospitalization and disease burden in the United States and globally. Therefore, developing an effective therapeutic regimen against influenza requires a comprehensive understanding of the damage-associated immune-mechanisms to identify therapeutic targets for interventions to mitigate inflammation\/tissue-damage, improve antiviral immunity, and prevent influenza-associated secondary bacterial diseases. In this review, the pathogenic immune mechanisms implicated in acute lung injury and the possibility of using lung inflammation and barrier crosstalk for developing therapeutics against influenza are highlighted.<\/jats:p>","DOI":"10.1002\/jlb.4ru0820-232r","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T03:54:19Z","timestamp":1600142059000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["From virus to inflammation, how influenza promotes lung damage"],"prefix":"10.1093","volume":"110","author":[{"given":"Mitchell","family":"Klomp","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Abigail Wexner Research Institute at Nationwide Children's Hospital , Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohail","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of North Dakota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-4989","authenticated-orcid":false,"given":"M","family":"Nadeem Khan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota , Grand Forks, North Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"2023032108481210300_","doi-asserted-by":"crossref","first-page":"020421","DOI":"10.7189\/jogh.09.020421","article-title":"Global mortality associated with seasonal influenza epidemics: new burden estimates and predictors 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