{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:07:05Z","timestamp":1761156425823},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Resistance of mice to Salmonella, typhimurium in the early phase of infection is known to be controlled by the expression of chromosome 1 locus Ity. To clarify the mechanism by which the genetically resistant (Ityr) mice can overcome the first phase of salmonellosis, the early response in DBA\/2 (Ityr) and BALB\/c (Itys) mice was compared after a subcutaneous injection of S. typhimurium. In both strains, the growth of S. typhimurium was controlled in livers and Kupffer cells until day 3, but thereafter the bacteria multiplied rapidly in BALB\/c mice. Over the first 2 days nonspecific responses (changes in levels of blood leukocytes, plasma iron, and \u03b11-antitrypsin) were not significantly different between the strains, and the capacity of Kupffer cells isolated from infected mice of both strains to produce interleukin 1 (IL-1) and tumor necrosis factor \u03b1 (TNF-\u03b1) was of the same degree. Thereafter, only DBA\/2 Kupffer cells were able to produce membrane-associated IL-1 (ma IL-1) as well as TNF-\u03b1. Moreover, only DBA\/2 splenocytes were able to produce interferon \u03b3 (IFN-\u03b3) upon stimulation with Salmonella antigens, although concanavalin A-stimulated splenocytes of both strains produced the same level of interleukin 2. Furthermore, administration of recombinant murine IFN-\u03b3 and DBA\/2 Kupffer cells of day 6 to BALB\/c mice 3 days after infection resulted in a significant level of protection, whereas neither of these materials alone induced protection. Injection of anti-TNF-\u03b1 antibodies did not affect the resistance of DBA\/2 mice. Thus, these findings suggest that the early resistance of Ityr mice is partly attributable to their capacity to produce IFN-\u03b3 and ma IL-1 after infection.<\/jats:p>","DOI":"10.1002\/jlb.51.3.244","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:26:55Z","timestamp":1515785215000},"page":"244-250","source":"Crossref","is-referenced-by-count":16,"title":["Contribution of interferon \u03b3 and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice"],"prefix":"10.1093","volume":"51","author":[{"given":"Eiji","family":"Kita","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Emoto","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Oku","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Hamuro","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Kamikaidou","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Kashiba","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Nara Medical University , Kashihara, Nora, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,3,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.51.3.244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/51\/3\/244\/48567711\/jlb0244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/51\/3\/244\/48567711\/jlb0244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T08:04:13Z","timestamp":1676880253000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/51\/3\/244\/6977457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1992,3,1]]},"published-print":{"date-parts":[[1992,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.51.3.244","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,3]]},"published":{"date-parts":[[1992,3,1]]}}}