{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:09:50Z","timestamp":1768460990164,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To test our hypothesis that monocytes (M\u00d8) and their mediators are major contributors to ethanol- related immunodepression, the modulating capacity of acute ethanol treatment was assessed on the production of transforming growth factor-beta (TGF\u03b2) and prostaglandin E2 (PGE2) by human peripheral blood M\u00d8. We demonstrate that acute in vitro treatment of adherent MO with either 50 or 150 mM ethanol induced a significant increase in the production of TGF\u03b2 (P &amp;lt; 0.045 and \u03b2 &amp;lt; 0.001, respectively). Furthermore, M\u00d8 pretreatment with both 50 and 150 mM ethanol augmented TGFjS production in response to subsequent stimulation with the synthetic bacterial analog, muramyl dipeptide (MDP) (P &amp;lt; 0.05 and \u03b2 &amp;lt; 0.001, respectively). Ethanol also increased TGF\u00d8 production in interferon \u03b2 (IFN\u03b2)- activated M\u00d8 in response to MDP stimulus (P &amp;lt; 0.05). M\u00d8 TGF\u03b2 levels, however, were always lower in IFN\u03b2- activated than in non-IFN\u03b2-activated M\u00d8 after the same stimulation with ethanol plus MDP, suggesting that M\u00d8 preactivation by IFN7 can partially counteract the TGF\u03b2 inducing potential of ethanol. Similar to its TGF\u03b2 - inducing potential, ethanol (150 mM) had the capacity to induce PGE2 production in adherent human M\u00d8 (P &amp;lt; 0.045). However, ethanol failed to augment M\u00d8 PGE2 production induced by the PGE2 secretagogue, MDP. TGFjS induction by ethanol was unaffected by the presence of cyclooxygenase inhibitor, suggesting that ethanol-induced M\u00d8 TGF\u00df production does not require M\u00d8 PG\u00a32 production. These results indicate that ethanol is a potent inducer for inhibitory M\u00d8 mediators, TGFjS and PGE2, and also has the capacity to augment M\u00d8 TGF\u00df production in response to subsequent stimulation. Thus, ethanol-induced elevation of M\u00d8 TGF\u00df and PGE2 production might contribute to decreased \u03b2 cell proliferation and abnormal M\u00d8 functions after alcohol exposure, resulting in a depressed immune response.<\/jats:p>","DOI":"10.1002\/jlb.52.6.602","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:11:33Z","timestamp":1515784293000},"page":"602-610","source":"Crossref","is-referenced-by-count":37,"title":["Induction of transforming growth factor-beta and prostaglandin E2 production by ethanol in human monocytes"],"prefix":"10.1093","volume":"52","author":[{"given":"Gyongyi","family":"Szabo","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Massachusetts Medical Center , Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bikash K","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Massachusetts Medical Center , Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miklos","family":"Fogarasi","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Massachusetts Medical Center , Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna E","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Massachusetts Medical Center , Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,12,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.52.6.602","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/52\/6\/602\/49768361\/jlb0602.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/52\/6\/602\/49768361\/jlb0602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T07:00:48Z","timestamp":1681196448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/52\/6\/602\/6977297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1992,12,1]]},"published-print":{"date-parts":[[1992,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.52.6.602","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1992,12]]},"published":{"date-parts":[[1992,12,1]]}}}