{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:16:17Z","timestamp":1790964977066,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In op\/op mice, immunohistochemical and electron microscopic techniques were used to examine the effects of the OP mutation on dendritic cell populations in lymphoid tissues and skin. In the thymic medulla, T cell zone of lymph nodes, and splenic white pulp of op\/op mice, numbers of NLDC-145-positive dendritic cells were not decreased. Compared to the normal litter- mates, numbers of BM8-positive macrophages were reduced in various tissues of the mutant mice, including the lymphoid tissues. These dendritic cells of op\/op mice expressed la antigens but not F4\/80 and BM8 antigens. Ultrastructurally, the dendritic cells developed a tubulo- vesicular system typical of interdigitating cells, but they were abnormal in that interdigitation of their cytoplasmic processes was not prominent. In the epidermis of the op\/op mice, dendritic cells expressed NLDC-145, F4\/80, la antigens, and adenosine diphosphatase or adenosine triphosphatase activity, and numbers of NLDC-145-, la-, or ADPase-positive dendritic cells were reduced slightly, but these reductions were not significant statistically. Bir- beck granules were detected in most of them electron microscopically. These results indicate that nonlymphoid dendritic cells develop in the lymphoid tissues and skin of op\/op mouse, suggesting that they are differentiated from granulocyte-macrophage colony-forming cells or earlier hematopoietic cell precursors. J. Leukoc. Biol. 53: 19\u201328; 1993.<\/jats:p>","DOI":"10.1002\/jlb.53.1.19","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:12:23Z","timestamp":1515784343000},"page":"19-28","source":"Crossref","is-referenced-by-count":46,"title":["Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (<i>op<\/i>) mutation"],"prefix":"10.1093","volume":"53","author":[{"given":"Kiyoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Second Department of Pathology, Kumamoto University School of Medicine , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Naito","sequence":"additional","affiliation":[{"name":"Second Department of Pathology, Kumamoto University School of Medicine , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard D","family":"Shultz","sequence":"additional","affiliation":[{"name":"Jackson Laboratory, Bar Harbor , Maine, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medical Sciences , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medical Sciences , Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1993,1,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.53.1.19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/1\/19\/49769267\/jlb0019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/1\/19\/49769267\/jlb0019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T06:53:03Z","timestamp":1681195983000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/53\/1\/19\/6977156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1993,1,1]]},"published-print":{"date-parts":[[1993,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.53.1.19","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,1]]},"published":{"date-parts":[[1993,1,1]]}}}