{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:17:40Z","timestamp":1770981460604,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fish oils are abundant in polyunsaturated fatty acids of the n-3 series (in particular eicosapen- taenoic, 20:5 and docosahexaenoic acid, 22:6). Such fatty acids are generally considered to be beneficial in the prevention of cardiac disease and to have anti-inflammatory properties. Neutrophil adherence is an essential early event in an acute inflammatory response, and we have demonstrated that both 20:5 and 22:6 stimulate adherence in vitro. Arachidonic acid (20:4, n-6) was also stimulatory. Significant stimulation of adherence was seen from 5 to 80 \u03bcM (nontoxic concentrations) 22:6, 20:5, or 20:4. At the lower fatty acid concentrations tested (\u226440 \u03bcM) 20:5 was less active than 22:6 or 20:4 at stimulating adherence. Above 40 \u03bcM there was no difference in the ability of the three fatty acids to stimulate adherence. At the lower fatty acid concentrations tested (\u226410 \u03bcM) 22:6 was less active than 20:4, whereas above 10 \u03bcM they were equally active. Immunofluorescent flow cytometric analysis of neutrophil integrin (adherence) receptors showed that the complement G3bi receptor (GDI lb) was up-regulated by these fatty acids. There was no change in GDI la or GDllc. Saturated fatty acids of the same chain length were without effect on adherence or receptor expression. The findings suggest that these polyunsaturated fatty acids may, under certain conditions, be proinflammatory with respect to their acute effects on the interaction of neutrophils with microbes, endothelium, and other tissues. J. Leukoc. Biol. 53: 420\u2013426; 1993.<\/jats:p>","DOI":"10.1002\/jlb.53.4.420","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:16:44Z","timestamp":1515784604000},"page":"420-426","source":"Crossref","is-referenced-by-count":43,"title":["Polyunsaturated fatty acids increase neutrophil adherence and integrin receptor expression"],"prefix":"10.1093","volume":"53","author":[{"given":"Edna J","family":"Bates","sequence":"first","affiliation":[{"name":"Department of Immunology and University of Adelaide Department of Paediatrics, Women\u2019s and Children\u2019s Hospital , Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Immunology and University of Adelaide Department of Paediatrics, Women\u2019s and Children\u2019s Hospital , Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne R","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Immunology and University of Adelaide Department of Paediatrics, Women\u2019s and Children\u2019s Hospital , Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alt","family":"Poulos","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, Women\u2019s and Children\u2019s Hospital , Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,4,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.53.4.420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/4\/420\/49768968\/jlb0420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/4\/420\/49768968\/jlb0420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T06:49:43Z","timestamp":1681195783000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/53\/4\/420\/6977171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1993,4,1]]},"published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.53.4.420","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,4]]},"published":{"date-parts":[[1993,4,1]]}}}