{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:10:56Z","timestamp":1770725456627,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Temporally distinct groups of cytokine expression were observed by reverse transcription-polymerase chain reaction assay, in situ hybridization, and immuno- histochemistry in the livers of Listeria monocytogenes- infected mice. One group consisted of interferon-7 (IFN- \u03b3), tumor necrosis factor a (TNF-\u03b1), and interleukin-10 (IL-10), for which mRNAs were induced within 1 day after challenge. A second group consisted of IL-2 and IL-4, for which mRNA was strongly expressed at 1 day but then suppressed at 3 days into the infection. Granulocyte- macrophage colony-stimulating factor (GM-CSF), IL-la, and IL-6 mRNA constituted a third group, which was increased at 3 days after challenge. Distributions of cytokine mRNA-expressing cells in the liver was observed by in situ hybridization. Cells expressing TNF-\u03b1 and IL-l\u03b1 mRNA were present throughout liver granulomas, whereas cells that expressed IFN-\u03b3 mRNA were observed mostly along the periphery of granulomas. Cells expressing IL-2, IL-4, IL-6, IL-10, and GM-CSF mRNA were distributed principally in the hepatic sinuses. Cells expressing IL-10 mRNA increased in number early in the infection when L. monocytogenes was multiplying in the liver. We conclude that cytokine mRNA expression during the early phases of L. monocytogenes infection in mice is temporally regulated and that IFN-7, TNF-\u03b1, and IL-l\u03b1 are expressed by cells associated with hepatic granulomas. J. Leukoc. Biol. 53: 525\u2013531; 1993.<\/jats:p>","DOI":"10.1002\/jlb.53.5.525","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:09:38Z","timestamp":1515784178000},"page":"525-531","source":"Crossref","is-referenced-by-count":27,"title":["Cytokine mRNA expression in livers of mice infected with <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"53","author":[{"given":"R Doug","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine , Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CJ","family":"Czuprynski","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine , Madison"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,5,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.53.5.525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/5\/525\/49768919\/jlb0525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/53\/5\/525\/49768919\/jlb0525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T06:49:38Z","timestamp":1681195778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/53\/5\/525\/6977435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1993,5,1]]},"published-print":{"date-parts":[[1993,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.53.5.525","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,5]]},"published":{"date-parts":[[1993,5,1]]}}}