{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:17Z","timestamp":1790483177169,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1993,8,1]],"date-time":"1993-08-01T00:00:00Z","timestamp":744163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this report, we show that the pl4 subunit of calcium-binding myeloid protein complex (p8,14) is phosphorylated in human neutrophils stimulated with either fMet-Leu-Phe, phorbol myristate acetate, or a calcium ionophore. Trifluoperazine, a calmodulin antagonist, caused hyperphosphorylation of pi 4 in intact resting neutrophils. Freincubation of resting cells with 10-20 nM calyculin A, a potent protein phosphatase inhibitor, also caused enhanced labeling of pi 4, which was further progressively increased on stimulation with fMLP. Thus, the phosphorylation level of pi 4 in resting as well as in stimulated neutrophils appears to be controlled by an active protein phosphatase. The phosphorylation of pi 4 by a chemoattractant and by a phorbol ester is a novel finding supporting the current belief that p8,14 myeloid protein may play an important role in the metabolism of myeloid cells.<\/jats:p>","DOI":"10.1002\/jlb.54.2.114","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:08:29Z","timestamp":1515784109000},"page":"114-118","source":"Crossref","is-referenced-by-count":12,"title":["Calcium-binding myeloid protein (P8,14) is phosphorylated in fMet-Leu-Phe-stimulated neutrophils"],"prefix":"10.1093","volume":"54","author":[{"given":"Carmela","family":"Bengis-Garber","sequence":"first","affiliation":[{"name":"Biochemical Research Unit, Department of Biochemistry, Lady Davis Carmel Hospital , Haifa , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nachman","family":"Gruener","sequence":"additional","affiliation":[{"name":"Biochemical Research Unit, Department of Biochemistry, Lady Davis Carmel Hospital , Haifa , Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1993,8,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.54.2.114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/54\/2\/114\/49769771\/jlb0114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/54\/2\/114\/49769771\/jlb0114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T06:48:26Z","timestamp":1681195706000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/54\/2\/114\/6978626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1993,8,1]]},"published-print":{"date-parts":[[1993,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.54.2.114","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1993,8]]},"published":{"date-parts":[[1993,8,1]]}}}