{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:56:27Z","timestamp":1763499387741},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytokines are known to be key players in host response to infection, immunological disorders, and tissue injury in the attempt of an organism to overcome the insult and restore homeostasis. Another important aspect of cytokines, however, is their normal physiological role during development in the unchallenged organism. The most elegant way to analyze both of these functions is to introduce targeted mutations in embryonic stem cells in order to create new mouse strains deficient for a given cytokine and identify the functions that are consequently impaired or lost, This review summarizes the mutant phenotypes of mice carrying a null mutation in the cytokine IL-6 gene or the tumor necrosis factor receptor 1 (Tnfr1) gene. Results for interferon\u2013 and interferon-\u03b3 receptor-deficient mice are included for comparison. J. Leukoc. Biol. 56: 565\u2013570; 1994.<\/jats:p>","DOI":"10.1002\/jlb.56.5.565","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:39:37Z","timestamp":1515785977000},"page":"565-570","source":"Crossref","is-referenced-by-count":43,"title":["Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice"],"prefix":"10.1093","volume":"56","author":[{"given":"Horst","family":"Bluethmann","sequence":"first","affiliation":[{"name":"Department of Biology, Pharmaceutical Research New Technologies, F. Hoffmann-La Roche Ltd , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Rothe","sequence":"additional","affiliation":[{"name":"Department of Biology, Pharmaceutical Research New Technologies, F. Hoffmann-La Roche Ltd , Basel , Switzerland"},{"name":"Imperial Cancer Research Fund , Lincoln\u2019s Inn Fields 44, London WC2A 3PX , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Schultze","sequence":"additional","affiliation":[{"name":"Department of Biology, Pharmaceutical Research New Technologies, F. Hoffmann-La Roche Ltd , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tkachuk","sequence":"additional","affiliation":[{"name":"Department of Biology, Pharmaceutical Research New Technologies, F. Hoffmann-La Roche Ltd , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Koebel","sequence":"additional","affiliation":[{"name":"Department of Biology, Pharmaceutical Research New Technologies, F. Hoffmann-La Roche Ltd , Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,11,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.56.5.565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/56\/5\/565\/49770970\/jlb0565.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/56\/5\/565\/49770970\/jlb0565.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T05:18:45Z","timestamp":1681190325000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/56\/5\/565\/6978861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1994,11,1]]},"published-print":{"date-parts":[[1994,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.56.5.565","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,11]]},"published":{"date-parts":[[1994,11,1]]}}}