{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:55:24Z","timestamp":1790830524703,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T lymphocyte progenitors differentiate into two distinct T cell lineages. Although the \u03b1\u03b2 and \u03b3\u03b4 T cell lineages resemble each other phenotypically and functionally, there are some striking differences. Some \u03b3\u03b4 T cells recognize, similarly to \u03b1\u03b2 T cells, peptides presented by major histocompatibility complex (MHC) proteins or MHC-like molecules. However, there are \u03b3\u03b4 T cells that recognize MHC molecules in a fundamentally different manner in comparison with \u03b1\u03b2 T cells. Also in contrast to aL\u03b2 T lymphocytes, many \u03b3\u03b4 T cells are capable of recognizing nonpeptide antigens. Most responses of \u03b3\u03b4 T cells appear to be directed against microbial pathogenic agents including bacteria, parasites, and viruses. In particular, the potent cytotoxic responses of \u03b3\u03b4 T cells against cells infected with, for example, herpesviruses or lentiviruses may be essential for the overall antiviral defense of vertebrates. The analysis of antiviral immunosurveillance by \u03b3\u03b4 T cells is crucial for understanding the unique biological role of this lymphocyte subset.<\/jats:p>","DOI":"10.1002\/jlb.58.3.277","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:08:00Z","timestamp":1515784080000},"page":"277-283","source":"Crossref","is-referenced-by-count":50,"title":["Gamma\/delta T lymphocytes in viral Infections"],"prefix":"10.1093","volume":"58","author":[{"given":"Marianne","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology and Wisconsin Comprehensive Cancer Center, University of Wisconsin Medical School, and Wisconsin Regional Primate Research Center , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Malkovsky","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology and Wisconsin Comprehensive Cancer Center, University of Wisconsin Medical School, and Wisconsin Regional Primate Research Center , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R","family":"Carding","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania School of Medicine , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,9,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.58.3.277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/3\/277\/49764787\/jlb0277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/3\/277\/49764787\/jlb0277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:12:53Z","timestamp":1681283573000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/58\/3\/277\/6979056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,9,1]]},"published-print":{"date-parts":[[1995,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.58.3.277","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,9]]},"published":{"date-parts":[[1995,9,1]]}}}