{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:08:51Z","timestamp":1759226931224},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The amyloidogenic peptides, amyloid-\u03b2 (A\u03b2) and human amylin, are the major constituents of amyloid deposits found in patients with the chronic degenerative disorders Alzheimer\u2019s disease (AD) and type 2 diabetes, respectively. Recent studies have shown that a variety of inflammatory proteins such as cytokines are associated with the amyloid deposits of AD brain tissues. Therefore, in the present study, we sought to determine whether A\u03b2 and\/or human amylin could modulate the various inflammatory activities of eosinophils. We observed that human amylin but not A\u03b2 peptides inhibited the in vitro interleukin-5 (IL-5)\u2013mediated survival of cord blood\u2013derived eosinophils (CBEs) in a concentration-dependent manner. By contrast, rat amylin, a nonamyloidogenic peptide that is highly homologous to human amylin, failed to affect the IL-5\u2013mediated survival of CBEs. Similar inhibitory effects of human amylin were observed for peripheral blood eosinophils. Human amylin also enhanced the release of the cytokine granulocyte-macrophage colony-stimulating factor by CBEs that were stimulated with the calcium ionophore A23187 but was incapable of directly stimulating CBEs to release cytokines. In addition, the A23187-induced release of the inflammatory lipid mediator leukotriene C4 by CBEs was augmented by human amylin. These results suggest that the amyloidogenic peptide human amylin is capable of amplifying the various inflammatory activities of eosinophils.<\/jats:p>","DOI":"10.1002\/jlb.58.5.526","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:06:58Z","timestamp":1515784018000},"page":"526-532","source":"Crossref","is-referenced-by-count":10,"title":["The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils"],"prefix":"10.1093","volume":"58","author":[{"given":"Joanne T","family":"Horn","sequence":"first","affiliation":[{"name":"System Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Estridge","sequence":"additional","affiliation":[{"name":"System Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penni","family":"Pechous","sequence":"additional","affiliation":[{"name":"System Research, Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Hyslop","sequence":"additional","affiliation":[{"name":"Cardiovascular Research and Central Nervous, Eli Lilly and Company , Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,11,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.58.5.526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/5\/526\/49763996\/jlb0526.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/5\/526\/49763996\/jlb0526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:02:48Z","timestamp":1681282968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/58\/5\/526\/6979137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1995,11,1]]},"published-print":{"date-parts":[[1995,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.58.5.526","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,11]]},"published":{"date-parts":[[1995,11,1]]}}}