{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:12:29Z","timestamp":1783487549858,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Murine retrovirus infection induces loss of vitamin E and immune dysfunction with loss of cytokine production by T-helper cells. Therefore interferon-\u03b3 (IFN-\u03b3) was given during dietary vitamin E supplementation to effectively prevent murine retrovirus-induced immunosuppression, cytokine dysregulation, and development of murine AIDS. Administration of IFN-\u03b3 during vitamin E supplementation significantly prevented development of retrovirus-induced suppression of splenic natural killer cell activity and T cell proliferation. It also significantly slowed retrovirus-induced elevation of T helper (Th) 2 cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine (IL-6 and tumor necrosis factor-\u03b1) secretion by splenocytes. The treatment also prevented loss of Th1 cytokine (IL-2 and IFN-\u03b3) secretion by splenocytes from retrovirus-infected mice alleviating splenomegaly and hyper-gammaglobulinemia. The combined therapy had an additive therapeutic impact. It was more effective than IFN-\u03b3 treatment or vitamin E supplementation alone in delaying the development of retrovirus-induced immunosuppression with its cytokine dysregulation.<\/jats:p>","DOI":"10.1002\/jlb.58.6.698","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:09:13Z","timestamp":1515784153000},"page":"698-703","source":"Crossref","is-referenced-by-count":15,"title":["Vitamin E supplementation with interferon-\u03b3 administration retards immune dysfunction during murine retrovirus infection"],"prefix":"10.1093","volume":"58","author":[{"given":"James Y","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine and Nutritional Sciences Program, University of Arizona , Tucson, Arizona 85724"},{"name":"Division of Infectious Diseases, Department of Medicine, Hennepin County Medical Center , 701 S. Park Avenue, Minneapolis, MN 55415 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine and Nutritional Sciences Program, University of Arizona , Tucson, Arizona 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine and Nutritional Sciences Program, University of Arizona , Tucson, Arizona 85724"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,12,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.58.6.698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/6\/698\/49763973\/jlb0698.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/58\/6\/698\/49763973\/jlb0698.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:02:42Z","timestamp":1681282962000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/58\/6\/698\/6979118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1995,12,1]]},"published-print":{"date-parts":[[1995,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.58.6.698","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,12]]},"published":{"date-parts":[[1995,12,1]]}}}