{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:44:48Z","timestamp":1788345888647,"version":"build-2803163510"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Perinatology Research Branch"},{"DOI":"10.13039\/100000071","name":"NICHD\/NIH\/DHHS","doi-asserted-by":"publisher","award":["HHSN275201300006C"],"award-info":[{"award-number":["HHSN275201300006C"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wayne State University Perinatal Initiative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates. The direct contact between preterm or term neonatal CD71+ erythroid cells and maternal mononuclear immune cells, but not soluble products from these cells, induced the release of proinflammatory cytokines and a reduction in the release of TGF-\u03b2. Moreover, PTL-derived neonatal CD71+ erythroid cells (1) modestly altered CD8+ T cell activation; (2) inhibited conventional CD4+ and CD8+ T-cell expansion; (3) suppressed the expansion of CD8+ regulatory T cells; (4) regulated cytokine responses mounted by myeloid cells in the presence of a microbial product; and (5) indirectly modulated T-cell cytokine responses. In conclusion, neonatal CD71+ erythroid cells regulate neonatal T-cell and myeloid responses and their direct contact with maternal mononuclear cells induces a proinflammatory response. These findings provide insight into the biology of neonatal CD71+ erythroid cells during the physiologic and pathologic processes of labor.<\/jats:p>","DOI":"10.1002\/jlb.5a0717-291rrr","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T14:54:09Z","timestamp":1517496849000},"page":"761-775","source":"Crossref","is-referenced-by-count":32,"title":["CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses"],"prefix":"10.1093","volume":"103","author":[{"given":"Derek","family":"Miller","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"},{"name":"Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine , Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, University of Michigan , Ann Arbor, Michigan, USA"},{"name":"Department of Epidemiology and Biostatistics, Michigan State University , East Lansing, Michigan, USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University , Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Unkel","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Vadillo-Ortega","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"},{"name":"Facultad de Medicina, UNAM, Branch at Instituto Nacional de Medicina Genomica , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine , Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nardhy","family":"Gomez-Lopez","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NICHD\/NIH\/DHHS , Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine , Detroit, Michigan, USA"},{"name":"Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine , Detroit, Michigan, 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