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Over the past 2 decades, immune cells have been considered as the main driver of psoriasis because the neutralizing antibodies targeting the IL-23\/IL-17 axis that regulates cross-talk between dendritic cells and T cells achieve tremendous success in the treatment of psoriasis. However, whether keratinocyte would be a driver of psoriasis or just an executor in response to immune cells is still under debate. In this review, we focus on the recent advances in the identification of keratinocyte as a trigger of psoriasis, summarize on the role of keratinocytes in self-perpetuating loop to maintain inflammation in psoriasis, and then discuss the possible roles of keratinocytes in the relapse of psoriasis.<\/jats:p>","DOI":"10.1002\/jlb.5mr0120-439r","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T08:17:47Z","timestamp":1584173867000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":212,"title":["Keratinocyte: A trigger or an executor of psoriasis?"],"prefix":"10.1093","volume":"108","author":[{"given":"Xinhui","family":"Ni","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-6738","authenticated-orcid":true,"given":"Yuping","family":"Lai","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"2023032108163449000_jlb10600-cit-0001","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2133.1985.tb15259.x","article-title":"The sequence of events in psoriatic plaque formation after tape-stripping","volume":"112","author":"Heng","year":"1985","journal-title":"Br J Dermatol"},{"key":"2023032108163449000_jlb10600-cit-0002","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/1523-1747.ep12520022","article-title":"Action spectrum for phototherapy of 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