{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:36:43Z","timestamp":1770485803295,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tumor necrosis factor \u03b1 (TNF-\u03b1) has multiple effects on iron homeostasis and erythropoiesis and has been implicated in the pathogenesis of the anemia of inflammation. We postulated that intracellular iron in turn may regulate the expression of TNF-\u03b1. In the human monocytic leukemia cell line, THP-1, low basal TNF-\u03b1 message levels were stimulated (sevenfold) when serum was excluded from the culture medium. Addition of hemin completely suppressed TNF-\u03b1 expression. Similarly, hemin suppressed lipopolysaccharide-induced expression of TNF-\u03b1. Snprotoporphyrin, an inhibitor of heme oxygenase (which releases iron from hemin), prevented hemin-induced suppression of TNF-\u03b1 expression. Conversely, the intracellular iron chelator, desferrioxamine, stimulated TNF-\u03b1 expression. Thus, the expression of TNF-\u03b1, itself a physiological regulator of iron homeostasis, appears to be controlled by intracellular levels of iron. J.<\/jats:p>","DOI":"10.1002\/jlb.62.4.547","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T17:57:05Z","timestamp":1515002225000},"page":"547-552","source":"Crossref","is-referenced-by-count":21,"title":["Suppression of TNF-\u03b1 gene expression by hemin: implications for the role of iron homeostasis in host inflammatory responses"],"prefix":"10.1093","volume":"62","author":[{"given":"Bernard J","family":"Silver","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Veterans Administration Medical Center and Case Western Reserve University , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly D","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Veterans Administration Medical Center and Case Western Reserve University , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Toossit","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Veterans Administration Medical Center and Case Western Reserve University , Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,10,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.62.4.547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/62\/4\/547\/49749090\/jlb0547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/62\/4\/547\/49749090\/jlb0547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:51:35Z","timestamp":1680673895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/62\/4\/547\/6979514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1997,10,1]]},"published-print":{"date-parts":[[1997,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.62.4.547","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,10]]},"published":{"date-parts":[[1997,10,1]]}}}