{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:25:22Z","timestamp":1748352322640},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1997,12,1]],"date-time":"1997-12-01T00:00:00Z","timestamp":880934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this work we characterize the Mycobacterium bovis bacillus Calmette-Gu\u00e9rin(BCC) -induced pleurisy and investigate the role of chemical mediators and cytokines in BCG-induced granulocyte accumulation at 24 h. Intrathoracic injection of BCG in C57B1\/6 mice induces a biphasic inflammatory reaction with intense leukocyte accumulation at 24 h and 15 days. Neutrophils were observed in the pleural cavity at 4-24 h, mononuclear cells and eosinophils after 24 h. A new wave of mononuclear cells and neutrophils were observed after 15 days. Pretreatments with dexamethasone, BW 755C, BW A4C, WEB 2170, L-NAME, and monoclonal antibody (mAb) anti-interleukin-5 (IL-5; TRFK-5) had inhibited the eosinophil accumulation. On the other hand, only the pretreatments with dexamethasone, L-NAME, or mAb antitumor necrosis factor a (TNF-\u03b1; MP6-XT3) had inhibited the neutrophil influx. These results suggest the involvement of leukotrienes, platelet-activating factor, nitric oxide, and IL-5 in the eosinophil accumulation, and a role for nitric oxide and TNF-\u03b1 in the neutrophil influx induced by BCG.<\/jats:p>","DOI":"10.1002\/jlb.62.6.778","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:04:55Z","timestamp":1515783895000},"page":"778-785","source":"Crossref","is-referenced-by-count":22,"title":["Effects of inhibitors of inflammatory mediators and cytokines on eosinophil and neutrophil accumulation induced by <i>Mycobacterium bovis bacillus Calmette-Gu\u00e9rin<\/i>in mouse pleurisy"],"prefix":"10.1093","volume":"62","author":[{"given":"Oct\u00e1vio","family":"Menezes-de-Lima-J\u00fanior","sequence":"first","affiliation":[{"name":"Department of Applied Pharmacology, Institute of Drug Technology, Far-Manguinhos , Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Werneck-Barroso","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Institute of Drug Technology, Far-Manguinhos , Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato S B","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Institute of Drug Technology, Far-Manguinhos , Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"das Gra\u00e7as","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Institute of Drug Technology, Far-Manguinhos , Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M O","family":"Henriques","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacodynamics, IOC, FIOCRUZ , Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1997,12,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.62.6.778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/62\/6\/778\/49749503\/jlb0778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/62\/6\/778\/49749503\/jlb0778.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:50:26Z","timestamp":1680673826000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/62\/6\/778\/6979613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1997,12,1]]},"published-print":{"date-parts":[[1997,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.62.6.778","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1997,12]]},"published":{"date-parts":[[1997,12,1]]}}}