{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:11:58Z","timestamp":1773285118033,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Macrophages (M\u03a6) have been implicated in the suppression of lymphocyte function following thermal injury. Splenocytes isolated from C57BL\/ 6NCR female mice 4\u20137 days after thermal injury displayed suppressed proliferative responses to Concanavalin A (ConA) and lipopolysaccharide (LPS) and high levels of reactive nitrogen intermediate (RNI) production. Inhibition of nitric oxide synthase activity with NG-monomethyl-L-arginine restored ConA responses but not LPS responses. Surprisingly, ConA-stimulated interferon-\u03b3 (IFN-\u03b3) production was increased in splenocytes from injured mice. IFN-\u03b3 contributed to the RNI-mediated immunosuppression as antibodies against IFN-\u03b3 reduced RNI production and immunosuppression. ConA-stimulated co-cultures of splenic M\u03a6 from injured mice and normal splenocytes produced high levels of RNI only under conditions of cellular contact and splenic m\u03a6 from injured mice were capable of suppressing normal splenocytes responses in co-culture. These results indicate that M\u03a6 activity and specifically RNI production contribute to the suppression of T lymphocyte function after thermal injury.<\/jats:p>","DOI":"10.1002\/jlb.63.1.51","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:03:42Z","timestamp":1515783822000},"page":"51-58","source":"Crossref","is-referenced-by-count":57,"title":["Thermal injury-induced immunosuppression in mice: the role of macrophage-derived reactive nitrogen intermediates"],"prefix":"10.1093","volume":"63","author":[{"given":"Martin G","family":"Schwacha","sequence":"first","affiliation":[{"name":"Center for Surgical Research and Department of Surgery, Brown University School of Medicine and Rhode Island Hospital , Providence"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D","family":"Somers","sequence":"additional","affiliation":[{"name":"Center for Surgical Research and Department of Surgery, Brown University School of Medicine and Rhode Island Hospital , Providence"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,1,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.63.1.51","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/1\/51\/49737396\/jlb0051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/1\/51\/49737396\/jlb0051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:50:06Z","timestamp":1680673806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/63\/1\/51\/6979589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1998,1,1]]},"published-print":{"date-parts":[[1998,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.63.1.51","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,1]]},"published":{"date-parts":[[1998,1,1]]}}}