{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:33:41Z","timestamp":1790512421551,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Activated neutrophils (PMN) have been implicated in the pathogenesis of adult respiratory distress syndrome (ARDS). Granulocyte colony-stimulating factor (G-CSF) is essential for PMN production and activation of PMN functions. We have recently shown that levels of G-CSF mRNA in a rat model of hemorrhagic shock correlated with severity of shock, PMN infiltration, pulmonary edema, and hypoxia. To determine whether increased tissue levels of G-CSF contribute to PMN recruitment and PMN-mediated injury, we instilled G-CSF into the lungs by intratracheal injection. Animals treated with G-CSF became hypoxic, hypocapnic, and alkalotic and demonstrated increased BAL fluid cellularity compared with control animals. The wet-to-dry ratio increased significantly after G-CSF instillation and peaked at 12 h. Histological examination of the lungs from G-CSF-treated rats revealed marked edema and increased PMN within the interstitium and alveoli. These results indicate that the presence of G-CSF alone in the lung can lead to recruitment of PMN, lung injury, and impaired pulmonary function, suggesting that local production of G-CSF may contribute to the development of lung damage and possibly ARDS in the setting of resuscitated hemorrhagic shock.<\/jats:p>","DOI":"10.1002\/jlb.63.2.169","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:55:12Z","timestamp":1515783312000},"page":"169-174","source":"Crossref","is-referenced-by-count":51,"title":["G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia"],"prefix":"10.1093","volume":"63","author":[{"given":"Christian","family":"Hierholzer","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Roedling","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R","family":"Billiar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Tweardy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Molecular Genetics and Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,2,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.63.2.169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/2\/169\/49748813\/jlb0169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/2\/169\/49748813\/jlb0169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:49:34Z","timestamp":1680673774000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/63\/2\/169\/6979532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,2,1]]},"published-print":{"date-parts":[[1998,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.63.2.169","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,2]]},"published":{"date-parts":[[1998,2,1]]}}}