{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:36Z","timestamp":1791400596967,"version":"4.3.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although humoral responses to Borrelia burgdorferi (Bb) have been shown to be protective in some animal models of Lyme disease, the role of T cells in this disease is less well understood. This work describes three Bb-specific T cell lines that prevent disease progression in syngeneic mice. The T cell lines were generated in C3H mice immunized with Bb in complete Freund's adjuvant. All lines were Bb-specific, CD4+, TCR\u03b1\u03b2+, and they proliferated and produced interferon-\u03b3 and interleukin-2 on stimulation with Bb. Injection of the cell lines into naive C3H recipients significantly reduced the number of organisms recoverable from the blood and tissues of infected mice and protected them from developing Bb-induced periarthritis. These studies demonstrated that Th1 cells can confer resistance to Bb infection in susceptible mice and suggested that the timing of this T cell response may be critical for determining disease outcome.<\/jats:p>","DOI":"10.1002\/jlb.63.5.542","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:46:27Z","timestamp":1515782787000},"page":"542-549","source":"Crossref","is-referenced-by-count":15,"title":["Specific Th1 cell lines that confer protective immunity against experimental <i>Borrelia burgdorferi<\/i> infection in mice"],"prefix":"10.1093","volume":"63","author":[{"given":"Michael W","family":"Pride","sequence":"first","affiliation":[{"name":"Department of Immunology, The University of Texas M. D. Anderson Cancer Center , Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Immunology, The University of Texas M. D. Anderson Cancer Center , Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Clifton","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, The University of Texas M. D. Anderson Cancer Center , Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerald J","family":"Killion","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, The University of Texas M. D. Anderson Cancer Center , Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L","family":"Kripke","sequence":"additional","affiliation":[{"name":"Department of Immunology, The University of Texas M. D. Anderson Cancer Center , Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,5,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.63.5.542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/5\/542\/49749008\/jlb0542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/5\/542\/49749008\/jlb0542.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:23:51Z","timestamp":1680672231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/63\/5\/542\/6979617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,5,1]]},"published-print":{"date-parts":[[1998,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.63.5.542","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,5]]},"published":{"date-parts":[[1998,5,1]]}}}