{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:25:55Z","timestamp":1770708355695,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We investigated the involvement of IL-8 in the delayed vascular permeability (VP) in rabbit lipopolysaccharide (LPS)-pleurisy. Maximal level of interleukin-8 (IL-8) was detected in pleural fluid at 2 h after LPS injection and anti-IL-8 inhibited the delayed VP by 90%. Injection of homologous IL-8 induced VP, the time-course of which preceded that of LPS-induced delayed VP. Production of IL-8 in LPS-pleurisy was inhibited with anti-tumor necrosis factor \u03b1 (TNF-\u03b1), whereas the production of TNF-\u03b1 was not affected with anti-IL-8. Injection of IL-8 did not induce TNF-\u03b1 production and anti-TNF-\u03b1 had no effect on IL-8-induced VP. Injection of homologous TNF-\u03b1 induced IL-8 production and VP, and TNF-\u03b1-induced delayed VP was blocked with anti-IL-8. These results indicate important roles of IL-8 in LPS-induced delayed VP and that TNF-\u03b1 causes the delayed VP through the production of IL-8.<\/jats:p>","DOI":"10.1002\/jlb.63.5.584","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:46:27Z","timestamp":1515782787000},"page":"584-590","source":"Crossref","is-referenced-by-count":21,"title":["IL-8 is an essential mediator of the increased delayed-phase vascular permeability in LPS-induced rabbit pleurisy"],"prefix":"10.1093","volume":"63","author":[{"given":"Takumi","family":"Fukumoto","sequence":"first","affiliation":[{"name":"Department of Pathology , Kumamoto, Japan"},{"name":"Department of Orthopedics, Kumamoto University School of Medicine , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Pathology , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teizo","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Immunopathology Section, Laboratory of Immunology, National Cancer Institute-Frederick Cancer Research and Development Center , Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunao","family":"Edamitsu","sequence":"additional","affiliation":[{"name":"Department of Pathology , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ohkawara","sequence":"additional","affiliation":[{"name":"Department of Pathology , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumasa","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Kumamoto University School of Medicine , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Pathology , Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,5,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.63.5.584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/5\/584\/49749004\/jlb0584.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/63\/5\/584\/49749004\/jlb0584.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:23:50Z","timestamp":1680672230000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/63\/5\/584\/6979634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,5,1]]},"published-print":{"date-parts":[[1998,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.63.5.584","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,5]]},"published":{"date-parts":[[1998,5,1]]}}}