{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:15:24Z","timestamp":1771654524039,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate the requirements for adhesion molecules in neutrophil emigration during peritonitis, mice received intraperitoneal injections of Streptococcus pneumoniae while the functions of multiple adhesion molecules were blocked. Emigration after 4 h was compromised by antibodies against ICAM-1 or genetic deficiency of ICAM-1. Anti-CD11a\/CD18 antibodies decreased emigration in ICAM-1 mutant mice, suggesting that ICAM-1 independent emigration requires CD11\/CD18 complexes. In contrast, mice mutant in ICAM-1 plus E-selectin showed no defect in emigration, suggesting that E-selectin commits neutrophils to an ICAM-1-dependent pathway during streptococcal peritonitis. However, in mutant mice lacking the three endothelial adhesion molecules E-selectin, P-selectin, and ICAM-1, emigration after 4 h was significantly compromised. Thus, P-selectin is essential to ICAM-1-and E-selectin-independent acute peritoneal inflammation. After 24 h of peritonitis, there were no differences between WT and E-selectin\/P-selectin\/ICAM-1 mutant mice, demonstrating that these endothelial adhesion molecules are not essential to neutrophil emigration during later stages of peritonitis. J. Leukoc. Biol. 64: 291\u2013297; 1998.<\/jats:p>","DOI":"10.1002\/jlb.64.3.291","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:56:03Z","timestamp":1515783363000},"page":"291-297","source":"Crossref","is-referenced-by-count":25,"title":["Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice"],"prefix":"10.1093","volume":"64","author":[{"given":"Joseph P","family":"Mizgerd","sequence":"first","affiliation":[{"name":"Physiology Program, Harvard School of Public Health , Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M","family":"Quinlan","sequence":"additional","affiliation":[{"name":"Section of Pulmonology and Intensive Care, Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University , Indianapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Physiology Program, Harvard School of Public Health , Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J","family":"Kutkoski","sequence":"additional","affiliation":[{"name":"Physiology Program, Harvard School of Public Health , Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C","family":"Bullard","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, University of Alabama , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur L","family":"Beaudet","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics and Howard Hughes Medical Institute, Baylor College of Medicine , Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire M","family":"Doerschuk","sequence":"additional","affiliation":[{"name":"Physiology Program, Harvard School of Public Health , Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,9,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.64.3.291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/64\/3\/291\/49737010\/jlb0291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/64\/3\/291\/49737010\/jlb0291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T05:18:34Z","timestamp":1680671914000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/64\/3\/291\/6976819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,9,1]]},"published-print":{"date-parts":[[1998,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.64.3.291","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,9]]},"published":{"date-parts":[[1998,9,1]]}}}