{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:23:35Z","timestamp":1770488615582,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eosinophils are known to express cytokines capable of promoting fibrosis. Interleukin-5 (IL-5) is important in regulating eosinophilopoiesis, eosinophil recruitment and activation. Lung IL-5 expression is elevated in pulmonary fibrosis, wherein the eosinophil is a primary source of fibrogenic cytokines. To determine the role of IL-5 in pulmonary fibrosis, the effects of anti-IL-5 antibody were investigated in a model of bleomycin-induced pulmonary fibrosis. Fibrosis was induced in mice by endotracheal bleomycin treatment. Animals were also treated with either anti-IL-5 antibody or control IgG. Lungs were then analyzed for fibrosis, eosinophil influx, chemotactic activity, and cytokine expression. The results show that a primary chemotactic activity at the height of eosinophil recruitment is IL-5. Furthermore, anti-IL-5 antibody caused significant reduction in lung eosinophilia, cytokine expression, and fibrosis. These findings taken together suggest an important role for IL-5 in pulmonary fibrosis via its ability to regulate eosinophilic inflammation, and thus eosinophil-dependent fibrogenic cytokine production. J. Leukoc. Biol. 64: 657\u2013666; 1998.<\/jats:p>","DOI":"10.1002\/jlb.64.5.657","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:47:20Z","timestamp":1515782840000},"page":"657-666","source":"Crossref","is-referenced-by-count":59,"title":["The role of IL-5 in bleomycin-induced pulmonary fibrosis"],"prefix":"10.1093","volume":"64","author":[{"given":"Mehrnaz","family":"Gharaee-Kermani","sequence":"first","affiliation":[{"name":"Departments of Pathology and Internal Medicine, University of Michigan Medical School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"McGarry","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, University of Michigan Medical School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, University of Michigan Medical School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Huffnagle","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, University of Michigan Medical School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W","family":"Egan","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute , Kenilworth, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sem H","family":"Phan","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Internal Medicine, University of Michigan Medical School , Ann Arbor"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,11,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.64.5.657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/64\/5\/657\/49732737\/jlb0657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/64\/5\/657\/49732737\/jlb0657.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T04:40:40Z","timestamp":1680669640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/64\/5\/657\/6977023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,11,1]]},"published-print":{"date-parts":[[1998,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.64.5.657","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1998,11]]},"published":{"date-parts":[[1998,11,1]]}}}