{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:27Z","timestamp":1791910527371,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe destructive Lyme arthritis was detected in the hind paws of hamsters infused with enriched populations of either CD4+ or CD4- T lymphocytes along with macrophages exposed in vitro to formalin-inactivated Borrelia burgdorferi and then infected with the Lyme spirochete. Swelling was detected 4 days after infection, increased rapidly, peaked on day 8 of infection, and gradually decreased. Similarly, severe destructive arthritis was induced in hamsters infused with enriched populations of unfractionated T lymphocytes and macrophages exposed to spirochetes after infection with B. burgdorferi. Histopathological examination affirmed that hamsters infused with CD4+, CD4-, or unfractionated T lymphocytes and macrophages exposed to B. burgdorferi-induced arthritis. In addition, macrophages exposed in vitro to B. burgdorferi demonstrated both conventional and coiling phagocytosis, suggesting a mechanism by which CD4+ and CD4- T lymphocytes induce arthritis, respectively. These findings demonstrate that both CD4+ and CD4- subpopulations of T lymphocytes are capable of interacting with macrophages for the induction of severe destructive Lyme arthritis. J. Leukoc. Biol. 65: 162\u2013170; 1999.<\/jats:p>","DOI":"10.1002\/jlb.65.2.162","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:51:19Z","timestamp":1515783079000},"page":"162-170","source":"Crossref","is-referenced-by-count":17,"title":["Macrophages interact with enriched populations of distinct T lymphocyte subsets for the induction of severe destructive Lyme arthritis"],"prefix":"10.1093","volume":"65","author":[{"given":"Brian K","family":"DuChateau","sequence":"first","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin , Madison"},{"name":"Departments of Bacteriology, University of Wisconsin , Madison"},{"name":"Medical Microbiology and Immunology, University of Wisconsin , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L","family":"Munson","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin , Madison"},{"name":"Departments of Bacteriology, University of Wisconsin , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M","family":"England","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, University of Wisconsin , Madison"},{"name":"Department of Pathology, Meriter Hospital , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Lovrich","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory and Department of Infectious Diseases, Gundersen Lutheran Medical Center , La Crosse, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Callister","sequence":"additional","affiliation":[{"name":"Microbiology Research Laboratory and Department of Infectious Diseases, Gundersen Lutheran Medical Center , La Crosse, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani R","family":"Jensen","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin , Madison"},{"name":"Medical Microbiology and Immunology, University of Wisconsin , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald F","family":"Schell","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin , Madison"},{"name":"Departments of Bacteriology, University of Wisconsin , Madison"},{"name":"Medical Microbiology and Immunology, University of Wisconsin , Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1999,2,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.65.2.162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/65\/2\/162\/49732185\/jlb0162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/65\/2\/162\/49732185\/jlb0162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T04:31:09Z","timestamp":1680669069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/65\/2\/162\/6976731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,2,1]]},"published-print":{"date-parts":[[1999,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.65.2.162","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1999,2]]},"published":{"date-parts":[[1999,2,1]]}}}