{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:45:45Z","timestamp":1791355545630,"version":"4.3.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute concanavalin A (Con A)-induced hepatitis in mice is an animal model for hepatic injury induced by activated T cells. The evolution of hepatic involvement can be followed from hour to hour by measuring serum transaminase levels. We investigated the possible role of endogenous interleukin-6 (IL-6) in this model. We found serum IL-6 levels and splenic IL-6 mRNA during Con A-induced hepatitis to be significantly lower in interferon-\u03b3 (IFN-\u03b3)-deficientmice, which are resistant against the Con A-induced syndrome, than in wild-type ones, suggesting that systemic IL-6 production favors development of hepatic injury. However, IL-6-deficient mice proved to be more susceptible to the disease than wild-type mice, indicating that endogenous IL-6 plays a predominantly hepatoprotective role. Experiments in which wild-type mice were treated with anti-IL-6 antibodies, before or after Con A challenge, allowed us to reconcile these contrasting observations. The antibody injections resulted in a biphasic alteration of serum IL-6 levels, initial neutralization being followed by rebound increased levels due to accumulation of IL-6 in the form of antigen-antibody complexes. The effect of antibody on disease severity differed depending on the time of injection. Antibody injection at 2.5 h post Con A resulted in delayed disease manifestation, whereas treatment initiated before Con A resulted in accelerated disease. We conclude that endogenous IL-6 plays a bimodal role. IL-6 present before Con A challenge as well as that induced in the very early phase after Con A injection triggers hepatoprotective pathways. Continuation of IL-6 production beyond this early phase, by some other pathway, seems to be harmful to hepato-cytes. J. Leukoc. Biol. 67: 90\u201396; 2000.M<\/jats:p>","DOI":"10.1002\/jlb.67.1.90","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T18:57:44Z","timestamp":1515783464000},"page":"90-96","source":"Crossref","is-referenced-by-count":43,"title":["Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice"],"prefix":"10.1093","volume":"67","author":[{"given":"Yoh-ichi","family":"Tagawa","sequence":"first","affiliation":[{"name":"Laboratory of Immunobiology, Rega Institute, University of Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Matthys","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Rega Institute, University of Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertine","family":"Heremans","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Rega Institute, University of Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Dillen","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Rega Institute, University of Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahur","family":"Zaman","sequence":"additional","affiliation":[{"name":"Division of Experimental Laboratory Medicine, University Hospital Gasthuisberg , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons","family":"Billiau","sequence":"additional","affiliation":[{"name":"Laboratory of Immunobiology, Rega Institute, University of Leuven , Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,1,1]]},"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlb.67.1.90","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/67\/1\/90\/49700539\/jlb0090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/67\/1\/90\/49700539\/jlb0090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T23:52:52Z","timestamp":1680220372000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/67\/1\/90\/6926706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,1,1]]},"published-print":{"date-parts":[[2000,1,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.67.1.90","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,1]]},"published":{"date-parts":[[2000,1,1]]}}}