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Among tissues, cells of the brain and heart possess unique excitatory properties that likely demand special support. Accordingly, existing evidence demonstrates that microglia in the brain has an active role in synaptic organization, control of neuronal excitability, phagocytic removal of debris, and trophic support during brain development. In the heart, recent studies suggest that cardiac macrophages are involved in the regulation of heart homeostasis by phagocytosis, production of trophic, and immune-related factors, and by forming direct contacts with cardiomyocytes to regulate electrical conduction. In this review, we discuss mechanisms associated with the high degree of specialization of resident macrophages in both tissues, their origin and heterogeneity, and their contributions in regulating homeostasis under steady-state and pathological conditions.<\/jats:p>\n               <jats:p>Review on the ontogeny and tissue specialized functions of microglia and cardiac macrophages and their role in heart and brain homeostasis and inflammation.<\/jats:p>","DOI":"10.1002\/jlb.6mr0118-041r","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T12:21:04Z","timestamp":1530102064000},"page":"743-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Specialized functions of resident macrophages in brain and heart"],"prefix":"10.1093","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8301-7216","authenticated-orcid":false,"given":"Jose Angel","family":"Nicol\u00e1s-\u00c1vila","sequence":"first","affiliation":[{"name":"Area of Cell and Developmental Biology, Fundaci\u00f3n CNIC , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-555X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Area of Cell and Developmental Biology, Fundaci\u00f3n CNIC , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-8344","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Area of Cell and Developmental Biology, Fundaci\u00f3n CNIC , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"2023032406115752000_jlb10186-cit-0001","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/nature04958","article-title":"Stem cells, ageing and the quest for immortality","volume":"441","author":"Rando","year":"2006","journal-title":"Nature"},{"key":"2023032406115752000_jlb10186-cit-0002","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"2023032406115752000_jlb10186-cit-0003","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain 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