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In this study, we investigated the importance of IL-4R\u03b1-expressing CD11c+ cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11ccreIL-4R\u03b1\u2212\/lox BALB\/c mice, which lacked IL-4R\u03b1 expression on dendritic cells and alveolar macrophages. Abrogation of IL-4R\u03b1 expression on CD11c+ cells affected activation of CD4+ T cells, resulting in reduced numbers of effector CD4+ T cells and impaired production of Th1 and Th2 cytokines by CD4+ T cells ex vivo. However, secretion of both type 1 and type 2 Ab isotypes was unchanged in infected CD11c-specific IL-4R\u03b1-deficient mice compared to littermate controls. Together, these data demonstrate that IL-4R\u03b1-expressing CD11c+ cells play an important role in maintaining cellular immunity during schistosomiasis in mice.<\/jats:p>\n               <jats:p>Review on IL-4R\u03b1-expressing CD11c+ cell contribution to maintaining optimal cellular immunity during acute schistosomiasis in mice.<\/jats:p>","DOI":"10.1002\/jlb.ma0318-115r","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T14:35:40Z","timestamp":1543588540000},"page":"307-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["IL-4R\u03b1-expressing CD11c+ cells contribute to driving optimal cellular responses during <i>Schistosoma mansoni<\/i> infection in mice"],"prefix":"10.1093","volume":"105","author":[{"given":"Hlumani","family":"Ndlovu","sequence":"first","affiliation":[{"name":"Department of Integrative Biomedical Sciences, University of Cape Town , Cape Town, South 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