{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:17:19Z","timestamp":1790281039579,"version":"4.1.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI100625"],"award-info":[{"award-number":["AI100625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI083019"],"award-info":[{"award-number":["AI083019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI104002"],"award-info":[{"award-number":["AI104002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F32 AI115935"],"award-info":[{"award-number":["F32 AI115935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI100625"],"award-info":[{"award-number":["AI100625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI083019"],"award-info":[{"award-number":["AI083019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI104002"],"award-info":[{"award-number":["AI104002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32 AI115935"],"award-info":[{"award-number":["F32 AI115935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pathogen recognition receptor (PRR) signaling is critical for triggering innate immune activation and the expression of immune response genes, including genes that impart restriction against virus replication. RIG-I-like receptors and TLRs are PRRs that signal immune activation and drive the expression of antiviral genes and the production of type I IFN leading to induction of IFN-stimulated genes, in part through the interferon regulatory factor (IRF) family of transcription factors. Previous studies with West Nile virus (WNV) showed that IRF3 and IRF7 regulate IFN expression in fibroblasts and neurons, whereas macrophages and dendritic cells (DCs) retained the ability to induce IFN-\u03b2 in the absence of IRF3 and IRF7 in a manner implicating IRF5 in PRR signaling actions. Here we assessed the contribution of IRF5 to immune gene induction in response to WNV infection in DCs. We examined IRF5-dependent gene expression and found that loss of IRF5 in mice resulted in modest and subtle changes in the expression of WNV-regulated genes. Anti-IRF5 chromatin immunoprecipitation with next-generation sequencing of genomic DNA coupled with mRNA analysis revealed unique IRF5 binding motifs within the mouse genome that are distinct from the canonical IRF binding motif and that link with IRF5-target gene expression. Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.<\/jats:p>\n                  <jats:p>IRF5 regulates distinct gene regulation programs associated with diverse cellular pathways following West Nile Virus infection in mouse dendritic cells.<\/jats:p>","DOI":"10.1002\/jlb.ma0318-136rrr","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:49:13Z","timestamp":1542707353000},"page":"411-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection"],"prefix":"10.1093","volume":"105","author":[{"given":"Kwan T","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, Washington, USA"},{"name":"Department of Biomedical Sciences, City University of Hong Kong , Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Ming","family":"Loo","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Knoll","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gale","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Washington , Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"2023032406200827200_jlb10267-cit-0001","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"2023032406200827200_jlb10267-cit-0002","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.4161\/onci.22475","article-title":"The IRF family of transcription factors: inception, impact and implications in oncogenesis","volume":"1","author":"Yanai","year":"2012","journal-title":"Oncoimmunology"},{"key":"2023032406200827200_jlb10267-cit-0003","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0952-7915(01)00305-3","article-title":"The interferon-alpha\/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors","volume":"14","author":"Taniguchi","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"2023032406200827200_jlb10267-cit-0004","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1349-7006.2007.00720.x","article-title":"Interferon regulatory factor family of transcription factors and regulation of oncogenesis","volume":"99","author":"Takaoka","year":"2008","journal-title":"Cancer Sci"},{"key":"2023032406200827200_jlb10267-cit-0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/34224","article-title":"Structure of IRF-1 with bound DNA reveals determinants of interferon regulation","volume":"391","author":"Escalante","year":"1998","journal-title":"Nature"},{"key":"2023032406200827200_jlb10267-cit-0006","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5501\/wjv.v2.i2.49","article-title":"Innate host responses to West Nile virus: implications for central nervous system immunopathology","volume":"2","author":"Rossini","year":"2013","journal-title":"World J Virol"},{"key":"2023032406200827200_jlb10267-cit-0007","doi-asserted-by":"crossref","first-page":"e1003541","DOI":"10.1371\/journal.ppat.1003541","article-title":"Innate immune sensing of flaviviruses","volume":"9","author":"Suthar","year":"2013","journal-title":"PLoS Pathog"},{"key":"2023032406200827200_jlb10267-cit-0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1443.020","article-title":"Toll-like receptor and RIG-I-like receptor signaling","volume":"1143","author":"Kawai","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"2023032406200827200_jlb10267-cit-0009","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gene.2011.21","article-title":"IRF7: activation, regulation, modification and function","volume":"12","author":"Ning","year":"2011","journal-title":"Genes Immun"},{"key":"2023032406200827200_jlb10267-cit-0010","doi-asserted-by":"crossref","first-page":"15325","DOI":"10.1074\/jbc.R700002200","article-title":"Triggering the innate antiviral response through IRF-3 activation","volume":"282","author":"Hiscott","year":"2007","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0011","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1371\/journal.ppat.0030106","article-title":"Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms","volume":"3","author":"Daffis","year":"2007","journal-title":"PLoS Pathog"},{"key":"2023032406200827200_jlb10267-cit-0012","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1128\/JVI.00918-08","article-title":"Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection","volume":"82","author":"Daffis","year":"2008","journal-title":"J Virol"},{"key":"2023032406200827200_jlb10267-cit-0013","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction","volume":"13","author":"Sato","year":"2000","journal-title":"Immunity"},{"key":"2023032406200827200_jlb10267-cit-0014","doi-asserted-by":"crossref","first-page":"e1000607","DOI":"10.1371\/journal.ppat.1000607","article-title":"Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7","volume":"5","author":"Daffis","year":"2009","journal-title":"PLoS Pathog"},{"key":"2023032406200827200_jlb10267-cit-0015","doi-asserted-by":"crossref","first-page":"e1003118","DOI":"10.1371\/journal.ppat.1003118","article-title":"IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling","volume":"9","author":"Lazear","year":"2013","journal-title":"PLoS Pathog"},{"key":"2023032406200827200_jlb10267-cit-0016","doi-asserted-by":"crossref","first-page":"11007","DOI":"10.1128\/JVI.01545-14","article-title":"Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection","volume":"88","author":"Thackray","year":"2014","journal-title":"J Virol"},{"key":"2023032406200827200_jlb10267-cit-0017","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/JVI.02276-15","article-title":"Interferon-regulatory factor 5-dependent signaling restricts orthobunyavirus dissemination to the central nervous system","volume":"90","author":"Proenca-Modena","year":"2016","journal-title":"J Virol"},{"key":"2023032406200827200_jlb10267-cit-0018","doi-asserted-by":"crossref","first-page":"21676","DOI":"10.1074\/jbc.M117.792721","article-title":"Interferon regulatory factor 5 (IRF5) suppresses hepatitis C virus (HCV) replication and HCV-associated hepatocellular carcinoma","volume":"292","author":"Cevik","year":"2017","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0019","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.4049\/jimmunol.1000482","article-title":"Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression","volume":"185","author":"Feng","year":"2010","journal-title":"J Immunol"},{"key":"2023032406200827200_jlb10267-cit-0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature03308","article-title":"Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors","volume":"434","author":"Takaoka","year":"2005","journal-title":"Nature"},{"key":"2023032406200827200_jlb10267-cit-0021","doi-asserted-by":"crossref","first-page":"14295","DOI":"10.1074\/jbc.M800501200","article-title":"Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response","volume":"283","author":"Paun","year":"2008","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0022","doi-asserted-by":"crossref","first-page":"E898","DOI":"10.1073\/pnas.1118155109","article-title":"Spontaneous mutation of the Dock2 gene in Irf5-\/- mice complicates interpretation of type I interferon production and antibody responses","volume":"109","author":"Purtha","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406200827200_jlb10267-cit-0023","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/intimm\/dxs114","article-title":"Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2","volume":"25","author":"Yasuda","year":"2013","journal-title":"Int Immunol"},{"key":"2023032406200827200_jlb10267-cit-0024","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1002\/art.23613","article-title":"Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients","volume":"58","author":"Niewold","year":"2008","journal-title":"Arthritis Rheum"},{"key":"2023032406200827200_jlb10267-cit-0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/annrheumdis-2011-200463","article-title":"IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus","volume":"71","author":"Niewold","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2023032406200827200_jlb10267-cit-0026","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/ard.2009.118315","article-title":"Association of IRF5 polymorphisms with activation of the interferon alpha pathway","volume":"69","author":"Rullo","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2023032406200827200_jlb10267-cit-0027","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1093\/hmg\/ddv095","article-title":"IFN-alpha production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases","volume":"24","author":"Berggren","year":"2015","journal-title":"Hum Mol Genet"},{"key":"2023032406200827200_jlb10267-cit-0028","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.4049\/jimmunol.1103319","article-title":"IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells","volume":"188","author":"Hedl","year":"2012","journal-title":"J Immunol"},{"key":"2023032406200827200_jlb10267-cit-0029","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1073\/pnas.0701266104","article-title":"Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus","volume":"104","author":"Graham","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406200827200_jlb10267-cit-0030","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.3389\/fimmu.2017.01938","article-title":"B Cell-Intrinsic Role for IRF5 in TLR9\/BCR-Induced human B cell activation, proliferation, and plasmablast differentiation","volume":"8","author":"De","year":"2017","journal-title":"Front Immunol"},{"key":"2023032406200827200_jlb10267-cit-0031","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1073\/pnas.0911193107","article-title":"Critical role of IRF-5 in regulation of B-cell differentiation","volume":"107","author":"Lien","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406200827200_jlb10267-cit-0032","first-page":"24","article-title":"ChIP-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy","volume":"21","author":"Rhee","year":"2012","journal-title":"Curr Protoc Mol Biol"},{"key":"2023032406200827200_jlb10267-cit-0033","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1128\/JVI.00768-06","article-title":"Resistance to alpha\/beta interferon is a determinant of West Nile virus replication fitness and virulence","volume":"80","author":"Keller","year":"2006","journal-title":"J Virol"},{"key":"2023032406200827200_jlb10267-cit-0034","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1093\/nar\/gkx594","article-title":"Data exploration, quality control and statistical analysis of ChIP-exo\/nexus experiments","volume":"45","author":"Welch","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023032406200827200_jlb10267-cit-0035","doi-asserted-by":"crossref","first-page":"e1002638","DOI":"10.1371\/journal.pcbi.1002638","article-title":"High resolution genome wide binding event finding and motif discovery reveals transcription factor spatial binding constraints","volume":"8","author":"Guo","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"2023032406200827200_jlb10267-cit-0036","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1101\/gr.136184.111","article-title":"ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia","volume":"22","author":"Landt","year":"2012","journal-title":"Genome Res"},{"key":"2023032406200827200_jlb10267-cit-0037","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2023032406200827200_jlb10267-cit-0038","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"2023032406200827200_jlb10267-cit-0039","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023032406200827200_jlb10267-cit-0040","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"key":"2023032406200827200_jlb10267-cit-0041","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat Biotechnol"},{"key":"2023032406200827200_jlb10267-cit-0042","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/gb-2007-8-2-r24","article-title":"Quantifying similarity between motifs","volume":"8","author":"Gupta","year":"2007","journal-title":"Genome Biol"},{"key":"2023032406200827200_jlb10267-cit-0043","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol"},{"key":"2023032406200827200_jlb10267-cit-0044","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1093\/nar\/gky002","article-title":"DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation","volume":"46","author":"Andrilenas","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032406200827200_jlb10267-cit-0045","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.celrep.2014.07.034","article-title":"IRF5:relA interaction targets inflammatory genes in macrophages","volume":"8","author":"Saliba","year":"2014","journal-title":"Cell Rep"},{"key":"2023032406200827200_jlb10267-cit-0046","doi-asserted-by":"crossref","first-page":"D1284","DOI":"10.1093\/nar\/gkx1188","article-title":"JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework","volume":"46","author":"Khan","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2023032406200827200_jlb10267-cit-0047","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.1162327","article-title":"Diversity and complexity in DNA recognition by transcription factors","volume":"324","author":"Badis","year":"2009","journal-title":"Science"},{"key":"2023032406200827200_jlb10267-cit-0048","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1074\/jbc.M109.063586","article-title":"Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis","volume":"285","author":"Hu","year":"2010","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0049","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1242\/jcs.180745","article-title":"FRMD4A-cytohesin signaling modulates the cellular release of tau","volume":"129","author":"Yan","year":"2016","journal-title":"J Cell Sci"},{"key":"2023032406200827200_jlb10267-cit-0050","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.0908423107","article-title":"FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex","volume":"107","author":"Ikenouchi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406200827200_jlb10267-cit-0051","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.devcel.2007.07.006","article-title":"A beta-catenin-independent dorsalization pathway activated by Axin\/JNK signaling and antagonized by aida","volume":"13","author":"Rui","year":"2007","journal-title":"Dev Cell"},{"key":"2023032406200827200_jlb10267-cit-0052","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12079-014-0241-y","article-title":"Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors","volume":"8","author":"Niimori","year":"2014","journal-title":"J Cell Commun Signal"},{"key":"2023032406200827200_jlb10267-cit-0053","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.dnarep.2010.08.002","article-title":"Transcription factor IIS impacts UV-inhibited transcription","volume":"9","author":"Jensen","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"2023032406200827200_jlb10267-cit-0054","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3109\/10409238.2010.512001","article-title":"Keeping it in the family: diverse histone recognition by conserved structural folds","volume":"45","author":"Yap","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2023032406200827200_jlb10267-cit-0055","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2012.04.043","article-title":"Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis","volume":"150","author":"Asencio","year":"2012","journal-title":"Cell"},{"key":"2023032406200827200_jlb10267-cit-0056","doi-asserted-by":"crossref","first-page":"31002","DOI":"10.1038\/srep31002","article-title":"Specific detection of interferon regulatory factor 5 (IRF5): a case of antibody inequality","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"2023032406200827200_jlb10267-cit-0057","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1182\/blood-2010-01-263020","article-title":"IRF5 is required for late-phase TNF secretion by human dendritic cells","volume":"115","author":"Krausgruber","year":"2010","journal-title":"Blood"},{"key":"2023032406200827200_jlb10267-cit-0058","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1128\/JVI.06867-11","article-title":"Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses","volume":"86","author":"Bedard","year":"2012","journal-title":"J Virol"},{"key":"2023032406200827200_jlb10267-cit-0059","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.gdata.2016.01.020","article-title":"Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway","volume":"7","author":"Green","year":"2016","journal-title":"Genom Data"},{"key":"2023032406200827200_jlb10267-cit-0060","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.0908423107","article-title":"FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex","volume":"107","author":"Ikenouchi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023032406200827200_jlb10267-cit-0061","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1242\/jcs.180745","article-title":"FRMD4A-cytohesin signaling modulates the cellular release of tau","volume":"129","author":"Yan","year":"2016","journal-title":"J Cell Sci"},{"key":"2023032406200827200_jlb10267-cit-0062","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.devcel.2007.07.006","article-title":"A beta-catenin-independent dorsalization pathway activated by Axin\/JNK signaling and antagonized by aida","volume":"13","author":"Rui","year":"2007","journal-title":"Dev Cell"},{"key":"2023032406200827200_jlb10267-cit-0063","doi-asserted-by":"crossref","first-page":"29198","DOI":"10.1074\/jbc.271.46.29198","article-title":"Identification and characterization of a leukocyte-specific component of the nuclear body","volume":"271","author":"Bloch","year":"1996","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0064","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3109\/10409238.2010.512001","article-title":"Keeping it in the family: diverse histone recognition by conserved structural folds","volume":"45","author":"Yap","year":"2010","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2023032406200827200_jlb10267-cit-0065","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1172\/JCI36452","article-title":"FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation","volume":"118","author":"Mancardi","year":"2008","journal-title":"J Clin Invest"},{"key":"2023032406200827200_jlb10267-cit-0066","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.immuni.2005.05.010","article-title":"FcgammaRIV: a novel FcR with distinct IgG subclass specificity","volume":"23","author":"Nimmerjahn","year":"2005","journal-title":"Immunity"},{"key":"2023032406200827200_jlb10267-cit-0067","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4049\/jimmunol.180.1.618","article-title":"Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes","volume":"180","author":"Jakus","year":"2008","journal-title":"J Immunol"},{"key":"2023032406200827200_jlb10267-cit-0068","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1089\/jir.2014.0113","article-title":"Murine Herc6 plays a critical role in protein ISGylation in vivo and has an ISGylation-Independent function in seminal vesicles","volume":"35","author":"Arimoto","year":"2015","journal-title":"J Interferon Cytokine Res"},{"key":"2023032406200827200_jlb10267-cit-0069","doi-asserted-by":"crossref","first-page":"e29870","DOI":"10.1371\/journal.pone.0029870","article-title":"HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells","volume":"7","author":"Oudshoorn","year":"2012","journal-title":"PLoS One"},{"key":"2023032406200827200_jlb10267-cit-0070","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03549","article-title":"Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment","volume":"3","author":"Han","year":"2014","journal-title":"Elife"},{"key":"2023032406200827200_jlb10267-cit-0071","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2012.04.043","article-title":"Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis","volume":"150","author":"Asencio","year":"2012","journal-title":"Cell"},{"key":"2023032406200827200_jlb10267-cit-0072","doi-asserted-by":"crossref","first-page":"12077","DOI":"10.1074\/jbc.M117.797126","article-title":"The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1beta transcription and activate the NLRP3 inflammasome","volume":"292","author":"Domingo-Fernandez","year":"2017","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0073","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1074\/jbc.RA117.001343","article-title":"The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility","volume":"293","author":"Stakaityte","year":"2018","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0074","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/eji.201041266","article-title":"Role of CLIC4 in the host innate responses to bacterial lipopolysaccharide","volume":"41","author":"He","year":"2011","journal-title":"Eur J Immunol"},{"key":"2023032406200827200_jlb10267-cit-0075","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.dnarep.2010.08.002","article-title":"Transcription factor IIS impacts UV-inhibited transcription","volume":"9","author":"Jensen","year":"2010","journal-title":"DNA Repair (Amst)"},{"key":"2023032406200827200_jlb10267-cit-0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2018.07.020","article-title":"TCEA1 regulates the proliferative potential of mouse myeloid cells","author":"Yang","year":"2018","journal-title":"Exp Cell Res"},{"key":"2023032406200827200_jlb10267-cit-0077","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1074\/jbc.M109.063586","article-title":"Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis","volume":"285","author":"Hu","year":"2010","journal-title":"J Biol Chem"},{"key":"2023032406200827200_jlb10267-cit-0078","doi-asserted-by":"crossref","first-page":"e2124","DOI":"10.1038\/cddis.2016.36","article-title":"Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis"},{"key":"2023032406200827200_jlb10267-cit-0079","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"2023032406200827200_jlb10267-cit-0080","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12079-014-0241-y","article-title":"Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors","volume":"8","author":"Niimori","year":"2014","journal-title":"J Cell Commun Signal"},{"key":"2023032406200827200_jlb10267-cit-0081","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ydbio.2012.08.030","article-title":"Tsukushi controls the hair cycle by regulating TGF-beta1 signaling","volume":"372","author":"Niimori","year":"2012","journal-title":"Dev Biol"},{"key":"2023032406200827200_jlb10267-cit-0082","first-page":"214","article-title":"OASL1 traps viral RNAs in stress granules to promote antiviral responses","volume":"41","author":"Kang","year":"2018","journal-title":"Mol Cells"},{"key":"2023032406200827200_jlb10267-cit-0083","doi-asserted-by":"crossref","first-page":"19089","DOI":"10.1038\/srep19089","article-title":"OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production","volume":"6","author":"Oh","year":"2016","journal-title":"Sci Rep"},{"key":"2023032406200827200_jlb10267-cit-0084","doi-asserted-by":"crossref","first-page":"e1003478","DOI":"10.1371\/journal.ppat.1003478","article-title":"Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8(+) T-cell exhaustion","volume":"9","author":"Lee","year":"2013","journal-title":"PLoS Pathog"},{"key":"2023032406200827200_jlb10267-cit-0085","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/ni.2535","article-title":"OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7","volume":"14","author":"Lee","year":"2013","journal-title":"Nat Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.MA0318-136RRR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.MA0318-136RRR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.MA0318-136RRR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/2\/411\/49557803\/jlb10267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/105\/2\/411\/49557803\/jlb10267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:14:50Z","timestamp":1775276090000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/105\/2\/411\/6935697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":85,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,11,20]]},"published-print":{"date-parts":[[2019,1,31]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.ma0318-136rrr","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,11,20]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}