{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:05:31Z","timestamp":1790723131838,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004933","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Toxinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004933","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Epidemiologia da Amazonia Ocidental"},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Rond\u00f4nia"},{"name":"Program for Technological Development","award":["473999\/2008-0"],"award-info":[{"award-number":["473999\/2008-0"]}]},{"name":"Program for Technological Development","award":["482562\/2010-2"],"award-info":[{"award-number":["482562\/2010-2"]}]},{"name":"Program for Technological Development","award":["479316-2013-6"],"award-info":[{"award-number":["479316-2013-6"]}]},{"name":"Program for Technological Development","award":["303974\/2008-7"],"award-info":[{"award-number":["303974\/2008-7"]}]},{"name":"Program for Technological Development","award":["301809\/2011-9"],"award-info":[{"award-number":["301809\/2011-9"]}]},{"name":"Program for Technological Development","award":["306672\/2014-6"],"award-info":[{"award-number":["306672\/2014-6"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004933","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Toxinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004933","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>BjcuL is a C-type lectin isolated from Bothrops jararacussu snake venom with specificity for binding \u03b2-d-galactose units. BjcuL is not toxic to human peripheral blood mononuclear cells (PBMCs), but it inhibits PBMC proliferation and stimulates these cells to produce superoxide anions and hydrogen peroxide primarily via lymphocyte stimulation; it does not stimulate the production of nitric oxide and PGE2. The purpose of this study was to investigate the effect of BjcuL on PBMC activation with a focus on cytokine release modulating PBMC proliferation. The results showed for the first time that BjcuL coupled to FITC interacted with monocytes, B cells, natural killer (NK) cells, and with subpopulations of T cells. These cell-cell interactions can lead to cell activation and inflammatory cytokines release, such as IL-6 and TNF-\u03b1, as well as the anti-inflammatory cytokine IL-10. In addition, TNF-\u03b1 release was attributed to NK cells and monocytes, whereas IL-10 was attributed to TCD4+ and Treg cells when stimulated by BjcuL. The temporal cytokines profile produced by cells when stimulated with this lectin allows us to assert that BjcuL has immunomodulatory activity in this context.<\/jats:p>","DOI":"10.1002\/jlb.ma1118-463r","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T14:47:27Z","timestamp":1557845247000},"page":"595-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lectin isolated from <i>Bothrops jararacussu<\/i> venom induces IL-10 release by TCD4+ cells and TNF-\u03b1 release by monocytes and natural killer cells"],"prefix":"10.1093","volume":"106","author":[{"given":"Weverson Luciano","family":"Pires","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Makoto","family":"Kayano","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"},{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade (CEBio), Universidade Federal de Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"},{"name":"Centro de Medicina Tropical de Rond\u00f4nia (CEPEM), Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onassis Boeri","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Valentino","family":"Paloschi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Amaral","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Nunes","family":"Boeno","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya dos Santos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Engenharia de Anticorpos, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edsa Mota","family":"Antunes","sequence":"additional","affiliation":[{"name":"Centro de Biologia Gastrointestinal, Instituto de Ci\u00eancias Biol\u00f3gicas , Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno Magalh\u00e3es S","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de An\u00e1lise e Visualiza\u00e7\u00e3o de Dados \u2013 Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Guerino","family":"St\u00e1beli","sequence":"additional","affiliation":[{"name":"Plataforma Bi-institucional de Medicina Translacional \u2013 Fiocruz S\u00e3o Paulo e Faculdade de Medicina de Ribeir\u00e3o Preto , Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"},{"name":"Departamento de Medicina da Universidade Federal de S\u00e3o Carlos , S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Freire Cel\u00eadonio","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Engenharia de Anticorpos, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreimar Martins","family":"Soares","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade (CEBio), Universidade Federal de Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"},{"name":"Centro Universit\u00e1rio S\u00e3o Lucas, UniSL , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pavan","family":"Zuliani","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunologia Celular Aplicada \u00e0 Sa\u00fade, FIOCRUZ Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"},{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade (CEBio), Universidade Federal de Rond\u00f4nia , Porto Velho, Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"2023032406295109800_jlb10409-cit-0001","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2023032406295109800_jlb10409-cit-0002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/trstmh\/try121","article-title":"Snakebite envenomation in the Brazilian Amazon: a descriptive study","volume":"113","author":"Magalh\u00e3es","year":"2018","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2023032406295109800_jlb10409-cit-0003","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1590\/0037-8682-0489-2017","article-title":"Epidemiological study of snakebite cases in Brazilian Western Amazonia","volume":"51","author":"Roriz","year":"2018","journal-title":"Rev Soc Bras Med Trop"},{"key":"2023032406295109800_jlb10409-cit-0004","first-page":"43","article-title":"Primary structure characterization of Bothrops jararacussu snake venom lectin","volume":"21","author":"de Carvalho","year":"2002","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tiv.2017.02.003","article-title":"Effect of BjcuL, a lectin isolated from Bothrops jararacussu, on human peripheral blood mononuclear cells","volume":"41","author":"Pires","year":"2017","journal-title":"Toxicol In Vitro"},{"key":"2023032406295109800_jlb10409-cit-0006","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0041-0101(01)00106-4","article-title":"Effect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells","volume":"31","author":"de Carvalho","year":"2001","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0007","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.toxicon.2014.08.062","article-title":"The lectin BjcuL induces apoptosis through TRAIL expression, caspase cascade activation and mitochondrial membrane permeability in a human colon adenocarcinoma cell line","volume":"90","author":"Damasio","year":"2014","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0008","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxicon.2011.10.012","article-title":"BJcuL, a lectin purified from Bothrops jararacussu venom, induces apoptosis in human gastric carcinoma cells accompanied by inhibition of cell adhesion and actin cytoskeleton disassembly","volume":"59","author":"Nolte","year":"2012","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0009","first-page":"4023","article-title":"The effect of a lectin from the venom of the snake, Bothrops jararacussu, on tumor cell proliferation","volume":"19","author":"Pereira-Bittencourt","year":"1999","journal-title":"Anticancer Res"},{"key":"2023032406295109800_jlb10409-cit-0010","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1590\/S1678-91992007000400009","article-title":"C-type lectin from Bothrops jararacussu venom can adhere to extracelular matrix proteins and induce the rolling of leukocytes","volume":"13","author":"Elifio-Esposito","year":"2007","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"2023032406295109800_jlb10409-cit-0011","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxicon.2005.08.012","article-title":"Biological activities of a lectin from Bothrops jararacussu snake venom","volume":"47","author":"Panunto","year":"2006","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-12-10","article-title":"Human neutrophil migration and activation by BJcuL, a galactose binding lectin purified from Bothrops jararacussu venom","volume":"12","author":"Elifio-Esposito","year":"2011","journal-title":"BMC Immunol"},{"key":"2023032406295109800_jlb10409-cit-0013","first-page":"118","article-title":"Bjcul, a snake venom lectin, modulates monocyte-derived macrophages to a pro-Inflammatory profile in vitro","volume":"33","author":"Dias-Netipanvi","year":"2016","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0120514","article-title":"A C-type lectin from Bothrops jararacussu venom disrupts staphylococcal biofilms","volume":"10","author":"Klein","year":"2015","journal-title":"PLoS ONE"},{"key":"2023032406295109800_jlb10409-cit-0015","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"2023032406295109800_jlb10409-cit-0016","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.toxicon.2016.05.013","article-title":"p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma","volume":"119","author":"Pontes","year":"2016","journal-title":"Toxicon"},{"key":"2023032406295109800_jlb10409-cit-0017","author":"Wickham","year":"2009"},{"key":"2023032406295109800_jlb10409-cit-0018"},{"key":"2023032406295109800_jlb10409-cit-0019","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-4165(02)00308-2","article-title":"Animal lectins: a historical introduction and overview","volume":"1572","author":"Kilpatrick","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"2023032406295109800_jlb10409-cit-0020","first-page":"1","article-title":"A novel lectin from Artocarpus lingnanensis induces proliferation and Th1\/Th2 cytokine secretion through CD45 signaling pathway in human T lymphocytes","volume":"1","author":"Cui","year":"2017","journal-title":"J Nat Med"},{"key":"2023032406295109800_jlb10409-cit-0021","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.cco.0000142070.45097.68","article-title":"A review of recent findings involving interleukin-2-based cancer therapy","volume":"16","author":"Eklund","year":"2004","journal-title":"Curr Opin Oncol"},{"key":"2023032406295109800_jlb10409-cit-0022","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.immunol.26.021607.090357","article-title":"The biology of interleukin-2","volume":"26","author":"Malek","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"2023032406295109800_jlb10409-cit-0023","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.3389\/fimmu.2018.02987","article-title":"Regulation of effector and memory CD8 T cell differentiation by IL-2-A balancing act","volume":"9","author":"Kalia","year":"2018","journal-title":"Front Immunol"},{"key":"2023032406295109800_jlb10409-cit-0024","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/ni.3540","article-title":"An essential role for IL-2 receptor in regulatory T cell function","volume":"17","author":"Chinen","year":"2016","journal-title":"Nat Immunol"},{"key":"2023032406295109800_jlb10409-cit-0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cyto.2015.07.005","article-title":"Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells","volume":"76","author":"Pandiyan","year":"2015","journal-title":"Cytokine"},{"key":"2023032406295109800_jlb10409-cit-0026","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","article-title":"Interleukin-10","volume":"11","author":"Moore","year":"1993","journal-title":"Annu Rev Immunol"},{"key":"2023032406295109800_jlb10409-cit-0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.1000465","article-title":"IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition","volume":"8","author":"Ropelle","year":"2010","journal-title":"PLoS Biol"},{"key":"2023032406295109800_jlb10409-cit-0028","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/eji.200838354","article-title":"A subset of IL-10-producing cd T cells protect the liver from Listeria-elicited, CD8+ T cell mediated injury","volume":"38","author":"Rhodes","year":"2008","journal-title":"Eur J Immunol"},{"key":"2023032406295109800_jlb10409-cit-0029","first-page":"2686","article-title":"IL-10 produced by activated human B cells regulates CD41 T-cell activation in vitro. Eur. J","volume":"40","author":"Bouazis","year":"2010","journal-title":"Immunol"},{"key":"2023032406295109800_jlb10409-cit-0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/eji.200324550","article-title":"Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro","volume":"34","author":"Benhauer","year":"2004","journal-title":"Eur J Immunol"},{"key":"2023032406295109800_jlb10409-cit-0031","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"2023032406295109800_jlb10409-cit-0032","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol Rev"},{"key":"2023032406295109800_jlb10409-cit-0033","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I and type-II interferon mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2023032406295109800_jlb10409-cit-0034","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"22","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"2023032406295109800_jlb10409-cit-0035","first-page":"1","article-title":"IL-6 signal transduction and its physiological roles: the signal orchestration model","volume":"149","author":"Kamimura","year":"2003","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"2023032406295109800_jlb10409-cit-0036","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00204-015-1461-5","article-title":"From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis","volume":"89","author":"Rath","year":"2015","journal-title":"Arch Toxicol"},{"key":"2023032406295109800_jlb10409-cit-0037","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2023032406295109800_jlb10409-cit-0038","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri1807","article-title":"Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells","volume":"6","author":"Dong","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"2023032406295109800_jlb10409-cit-0039","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 Family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Wever","year":"2007","journal-title":"Annu Rev Immunol"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2FJLB.MA1118-463R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/JLB.MA1118-463R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/JLB.MA1118-463R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/106\/3\/595\/49488161\/jlb10409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/106\/3\/595\/49488161\/jlb10409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T06:48:14Z","timestamp":1679640494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/106\/3\/595\/6935598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,5,14]]},"published-print":{"date-parts":[[2019,9,4]]}},"URL":"https:\/\/doi.org\/10.1002\/jlb.ma1118-463r","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,9]]},"published":{"date-parts":[[2019,5,14]]},"assertion":[{"value":"2019-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}