{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:42:35Z","timestamp":1785552155223,"version":"3.56.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pemphigus foliaceus (PF) is an autoimmune blistering skin disease characterized by the presence of bullous skin lesions, the absence of mucous tissue involvement, and the production of auto-antibodies directed against a keratinocyte transmembrane protein localized in the desmosome and member of the cadherines, desmoglein 1. These pathogenic auto-antibodies are responsible for the intra-epidermal formation of blisters through the loss of keratinocyte adhesion, the so-called acantholysis process. The endemic form of PF observed in the south of Tunisia is characterized by a significantly higher incidence rate compared to the sporadic form in northern countries, occurrence mainly in young women and the absence of cases during childhood. Tunisian endemic PF is an ideal research model for the decryption of the puzzle of genetic and environmental factors and their interactions in the development of autoimmune diseases. In this review, we will summarize recent findings regarding the epidemiologic and immunologic features of Tunisian PF and its genetic and environmental factors.<\/jats:p>\n               <jats:p>Review of recent findings regarding the epidemiologic and immunologic features of Tunisian PF and its genetic, environmental and hormonal factors.<\/jats:p>","DOI":"10.1002\/jlb.mr0318-132r","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T23:38:30Z","timestamp":1545435510000},"page":"257-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Update on immunogenetics of Tunisian endemic pemphigus foliaceus"],"prefix":"10.1093","volume":"105","author":[{"given":"Hatem","family":"Masmoudi","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Sfax , Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Abida","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Sfax , Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmen","family":"Masmoudi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Sfax , Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Turki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Sfax , Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"2023032406200858500_jlb10278-cit-0001","first-page":"767","article-title":"Tolerance, autoimmunity and auto-inflammation","author":"Kytaris","year":"2012"},{"key":"2023032406200858500_jlb10278-cit-0002","first-page":"404","article-title":"Diseases caused by immune responses: hypersensitivity and autoimmunity","author":"Abbas","year":"2000"},{"key":"2023032406200858500_jlb10278-cit-0003","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1172\/JCI110615","article-title":"Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes","volume":"70","author":"Stanley","year":"1982","journal-title":"J Clin Invest"},{"key":"2023032406200858500_jlb10278-cit-0004","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1172\/JCI23475","article-title":"Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction","volume":"115","author":"Waschke","year":"2005","journal-title":"J Clin Invest"},{"key":"2023032406200858500_jlb10278-cit-0005","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198205203062001","article-title":"Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease","volume":"306","author":"Anhalt","year":"1982","journal-title":"N Engl J Med"},{"key":"2023032406200858500_jlb10278-cit-0006","first-page":"1","article-title":"Experience with endemic dermatological diseases in the Peruvian wilderness: mucocutaneous leishmaniasis and Brazilian foliaceous pemphigus","volume":"4","author":"Heimgartner","year":"1976","journal-title":"Med Cutan Ibero Lat Am"},{"key":"2023032406200858500_jlb10278-cit-0007","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1067\/S0190-9622(03)00851-X","article-title":"A unique form of endemic pemphigus in northern Colombia","volume":"49","author":"Abr\u00e8u-Velez","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"2023032406200858500_jlb10278-cit-0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/archderm.1993.01680220081019","article-title":"Pemphigus foliaceus in young women. 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