{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:17:02Z","timestamp":1793722622458,"version":"4.6.1"},"reference-count":181,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Consejo Nacional de Tecnolog\u00eda","award":["CONACYT 281854"],"award-info":[{"award-number":["CONACYT 281854"]}]},{"name":"Consejo Nacional de Tecnolog\u00eda","award":["CONACYT 281854"],"award-info":[{"award-number":["CONACYT 281854"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The original discovery of NK cells approximately 40 yr ago was based on their unique capability to kill tumor cells without prior sensitization or priming, a process named natural cytotoxicity. Since then, several studies have documented that NK cells can kill hematopoietic and nonhematopoietic cancer cells. NK cells also recognize and kill cells that have undergone viral infections. Besides natural cytotoxicity, NK cells are also major effectors of antibody-dependent cell cytotoxicity (ADCC). Therefore, NK cells are well \u201carmed\u201d to recognize and mount immune responses against \u201cinsults\u201d that result from cell transformation and viral infections. Because of these attributes, an essential role of NK cells in tumor surveillance was noted. Indeed, several studies have shown a correlation between impaired NK cell cytotoxicity and a higher risk of developing cancer. This evidence led to the idea that cancer initiation and progress is intimately related to an abnormal or misdirected immune response. Whereas all these ideas remain current, it is also true that NK cells represent a heterogeneous population with different abilities to secrete cytokines and to mediate cytotoxic functions. In addition, recent data has shown that NK cells are prone to suffer epigenetic modifications resulting in the acquisition of previously unrecognized attributes such as memory and long-term survival. Such NK cells, referred as \u201cadaptive\u201d or \u201cmemory-like,\u201d also display effector functions that are not necessarily equal to those observed in conventional NK cells. Given the new evidence available, it is essential to discuss the conceptual reasoning and misconceptions regarding the role of NK cells in immune surveillance and immunotherapy.<\/jats:p>","DOI":"10.1002\/jlb.mr0618-224rr","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T15:01:50Z","timestamp":1552057310000},"page":"955-971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["From the \u201cmissing self\u201d hypothesis to adaptive NK cells: Insights of NK cell-mediated effector functions in immune surveillance"],"prefix":"10.1093","volume":"105","author":[{"given":"Mario Ernesto","family":"Cruz-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos , Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero","family":"Valenzuela-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos , Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"S\u00e1nchez-Herrera","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos , Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Santa-Olalla Tapia","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos , Cuernavaca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"2023032406173868400_jlb10349-cit-0001","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/smim.1995.0009","article-title":"Development of human NK cells from the immature cell precursors?","volume":"7","author":"Poggi","year":"1995","journal-title":"Semin Immunol"},{"key":"2023032406173868400_jlb10349-cit-0002","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis and function: parallels with CD8(+) T cells?","volume":"11","author":"Sun","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2023032406173868400_jlb10349-cit-0003","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival?","volume":"5","author":"Parham","year":"2005","journal-title":"Nat Rev 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