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B cells produce cytokines and are APCs for T cells. Recently, it has become clear that several pathogenic bacterial genera, such as Salmonella, Brucella, Mycobacterium, Listeria, Francisella, Moraxella, and Helicobacter, have evolved mechanisms such as micropinocytosis induction, inflammasome down-regulation, inhibitory molecule expression, apoptosis induction, and anti-inflammatory cytokine secretion to manipulate B cell functions influencing immune responses. In this review, we summarize our current understanding of B cells as targets of bacterial infection and the mechanisms by which B cells become a niche for bacterial survival and replication away from extracellular immune responses such as complement and antibodies.<\/jats:p>","DOI":"10.1002\/jlb.mr0618-225r","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T16:24:23Z","timestamp":1547828663000},"page":"905-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Beyond the antibody: B cells as a target for bacterial infection"],"prefix":"10.1093","volume":"105","author":[{"given":"Abraham","family":"Garc\u00eda-Gil","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Uriel","family":"Lopez-Bailon","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto Polit\u00e9cnico Nacional , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6546-9713","authenticated-orcid":false,"given":"Vianney","family":"Ortiz-Navarrete","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"2023032406173990300_jlb10318-cit-0001","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and 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