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This has raised interest in the role of the histaminergic system for the treatment and diagnosis of various pathologies such as allergy, sleeping and eating disorders, neurodegeneration, neuroinflammation, mood disorders, and pruritus.<\/jats:p><jats:p>In the past 20\u2009years, several ligands targeting the four different histamine receptor subtypes have been explored as potential radiotracers for positron emission tomography (PET). This contribution provides an overview of the developments of subtype\u2010selective carbon\u201011\u2010labeled and fluorine\u201018\u2010labeled compounds for imaging in the brain.<\/jats:p><jats:p>Using specific radioligands, the H<jats:sub>1<\/jats:sub>R expression in human brain could be examined in diseases such as schizophrenia, depression, and anorexia nervosa. In addition, the sedative effects of antihistamines could be investigated in terms of H<jats:sub>1<\/jats:sub>R occupancy. The H<jats:sub>3<\/jats:sub>R is of special interest because of its regulatory role in the release of various other neurotransmitters, and initial H<jats:sub>3<\/jats:sub>R PET imaging studies in humans have been reported. The H<jats:sub>4<\/jats:sub>R is the youngest member of the histamine receptor family and is involved in neuroinflammation and various sensory pathways. To date, two H<jats:sub>4<\/jats:sub>R\u2010specific <jats:sup>11<\/jats:sup>C\u2010labeled ligands have been synthesized, and the imaging of the H<jats:sub>4<\/jats:sub>R <jats:italic>in vivo<\/jats:italic> is in the early stage.<\/jats:p>","DOI":"10.1002\/jlcr.3038","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T01:31:43Z","timestamp":1366767103000},"page":"120-129","source":"Crossref","is-referenced-by-count":22,"title":["<sup>11<\/sup>C\u2010labeled and <sup>18<\/sup>F\u2010labeled PET ligands for subtype\u2010specific imaging of histamine receptors in the brain"],"prefix":"10.1002","volume":"56","author":[{"given":"Uta","family":"Funke","sequence":"first","affiliation":[{"name":"BV Cyclotron VU  De Boelelaan 1081 1081 HV Amsterdam The Netherlands"},{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle J.","family":"Vugts","sequence":"additional","affiliation":[{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bieneke","family":"Janssen","sequence":"additional","affiliation":[{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Spaans","sequence":"additional","affiliation":[{"name":"BV Cyclotron VU  De Boelelaan 1081 1081 HV Amsterdam The Netherlands"},{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perry S.","family":"Kruijer","sequence":"additional","affiliation":[{"name":"BV Cyclotron VU  De Boelelaan 1081 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan A.","family":"Lammertsma","sequence":"additional","affiliation":[{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars R.","family":"Perk","sequence":"additional","affiliation":[{"name":"BV Cyclotron VU  De Boelelaan 1081 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert D.","family":"Windhorst","sequence":"additional","affiliation":[{"name":"VU University Medical Center, Department of Radiology &amp; Nuclear Medicine Location Radionuclide Center  De Boelelaan 1085c 1081 HV Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8056-4_10"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07863.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6997(24)01328-0","volume":"49","author":"Hill S. 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